Tirz stopped working? Reta made me hungry. Send help (or snacks 🍕).

Thanks, that is helpful. Have not tried Cagri or the other new option yet and had not considered adding Sema either. Would like to hear how the second month goes.

Have the newer option in the freezer and another on order but started with the lowest-cost choice first since that seemed sensible. Plan to stay on Tirz long term for the other benefits but still need to lose more.

Anyone complaining about Reta below 2 mg gets added to the hall of shame. Split dosing makes reaching 2 mg easier, for example 1 mg twice weekly.

Reached 12 mg per week over six months with zero reduction in food noise and actually felt starving. Had every side effect including bad reflux, constipation, near gastroparesis, poor sleep, and sulfur burps yet still constant appetite. Switched compounds and lost nearly 30 pounds over eleven months.

Interesting. Did you use the newer compound without Tirz, and what dose did you take?

Totally understand starting with the cheaper option first. Makes sense if it works. Agree that Tirz is worth keeping for the longer-term benefits even while still needing to lose more.

Labs did not clarify the cause of the earlier issues. Will give the current dose more time to build up before changing again and will watch hydration better.

Living where the food is that good makes the situation harder. Interesting that you saw little change between 7 and 9 mg. The idea of just raising until something happens is tempting.

Understood about the time needed to rebuild levels. Restarted low and titrated slowly after the break, so the lack of effect still felt surprising compared with the first round.

Good to know others also see hunger increase with low-dose Reta. The two alternatives are noted as stronger options for control.

Makes sense that 0.8 mg is still very low. Higher amounts worked better for you, and using only one at a time seems reasonable.

Please do not add me to any hall of shame yet. Currently getting hunger on 0.8 mg instead of suppression. Split dosing to reach 2 mg sounds practical.

Sorry you went through all those side effects only to find it did not help appetite. Glad the switch led to nearly 30 pounds lost.

Agree that 5 mg is low so more time and slow increases on Tirz make sense. The food suggestion is noted even if eggs and spinach have lost appeal.

No problem. The food here is often purer. 9 mg worked but I dropped back to 7 mg with little difference noticed. After surgery I tapered but kept going with split doses of 3.5 mg twice a week. Goal weight is close now.

The combination works for many but drained my energy so it does not get much use. The spinach trick is still useful though.