Selank intranasal effects administration and alternatives for anxiety focus and depression

Thanks a lot. I will check it tomorrow.

Yeah estrogen swings can really disrupt things around menopause. I always figured I would hit 50 and get a big estrogen boost but several breast cancers showed up in close family so that option is off the table. The last few days have been even better after work. My job is busy and stressful with lots of patient interactions and I usually come home exhausted and flat. But the Semax and Selank really help with that.

I am sorry to hear about the cancers in the family. Glad you are looking after yourself. You should be getting paid for how well you promote this. The ADHD symptoms have been shifting since I stopped bupropion with my doctor’s okay, in a way that makes sense. Maybe February I will give it a try.

Go for it, try the nasal and let us know how it works out.

Did you get the Semax already mixed for nasal use? Do you know the strength? I mixed mine myself so two sprays give 1 mg. I use Semax nasal in the mornings right before work with my coffee and that sets me up for the day. I like it enough that I have the NA version on the way. From what I read Selank can be used any time for anxiety and in the morning for its mental clarity benefits.

I have been reading the risk is lower than people used to think. A new model shows that hormone replacement taken at 50 for up to five years only modestly raises breast cancer odds even with strong family history.

Now I want some too. Maybe it will help me sleep since my anxiety makes it hard to unwind.

I tried it under the skin and got almost no effect but after seeing this post I ordered the nasal spray vials and I am starting now. I will update in a week.

No the vial is 10 mg mixed with 10 ml saline and the nasal spray should deliver about 0.1 mg per spray though it is probably not very precise. You are right about Selank but it also lowers my stress on busy work days.

The shot under the skin felt like injecting saline while the nasal version actually works.

Yes thank you I know but I do not want to take any chance. I do not need it now and I am only perimenopausal but if full menopause symptoms hit I will think about it. Even a modest increase is still an increase. My best friend just finished treatment for breast cancer and it was awful plus she now has long term chemo side effects. It scares me.

I am not sure how long the spray stays good but you can use a small insulin case with ice packs to keep it cool while you are out so it lasts longer.

I have not looked into this myself and I have not found the original source so take it for what it is worth. From notes I made when first researching Selank several forums pointed to Russian studies showing stability data for the powder and reconstituted forms. The suggestions for extending shelf life were things like adding a tiny bit of ascorbic acid or using lower concentration. Personally I am looking at a 1.2 mg dose with two sprays per nostril three times a day. With a standard bottle that lasts about eight days. I still wonder how much agitation affects stability maybe worth testing.

Thanks the trauma part is long behind me. It was just a nonstop high stress home and I assumed every family was that way. I did not realize it had set my fight or flight system on high alert leading to anxiety. I am only now understanding how eighteen years of that changed things. The surprising part is how fast the Selank research quieted that background noise. I was going to start testing Semax on top of it but the package has been sitting in a distribution center for five days. Typical shipping issues.

I might be slow but what is BAK? So I could raise the dose in week two and three but I think I will just discard it after week three since there is no bac water and my nose is full of bacteria that could contaminate it.

I have kept mine for nearly thirty days refrigerated except when using it. After two weeks I started checking for particles or cloudiness and have not seen any yet. It is still clear even with plain saline. I need a couple more days from this bottle. After thirty days this week I will toss whatever is left and clean the bottle for next time. I am taking at least thirty days off to let receptors clear. I may also add a little store bought nasal spray next round.

My bottles are single use plastic and you cannot see through them so there is no way to check if mucus got inside.

Ah. I use amber Snoot bottles. They have a fairly strong spray so I do not think anything has entered. I wipe the tip after each use.

I am using the same bottles.

Yeah I agree after looking into everything thoroughly there's no point in stressing over it now. I'm excited for the next round using the adjusted version. From what I saw the duration extends to eight or ten hours rather than just a couple so I'm hoping my rest won't be disturbed.

Yeah the BAC saline could be what caused the irritation. 200 mcg is a pretty small amount so I'm not surprised you didn't notice much.

Semax goes in the morning for the boost. Selank comes an hour or so after that and then as needed. During the initial phase I'm using two sprays per nostril which is 400 mcg three times a day. After that I'll drop to 300-600 mcg total daily for a month and check how it goes.

Everything I've read about Adamax points to maximum potency compared with NA Semax Amidate. Start low and slow at 200 mcg and watch for the warning signs about when to stop. It's definitely a morning dose. Some people over 50 say the Amidate version is less vaso-restrictive and lowers blood pressure while others report it raises it a lot. I'm stopping at NA Semax even though Adamax sounds interesting because I'm already on BP meds.

If your dose is 0.1 ml per nostril or 0.2 ml total have you worked out what that comes to per day?

10 mg diluted with 10 ml of saline gives 1 mg per ml. The snoot bottle puts out roughly 0.1 ml per spray so that's about 100 mcg per spray. The protocol I'm following calls for 1.2 mg per day during the loading phase so that means two sprays per nostril three times a day.

Thanks. Can you walk me through the reconstitution step by step? I have a 10 mg vial of Selank. Should I use 3 ml sterile water draw it into the snoot bottle then add another 7 ml to reach 10 ml total with the 10 mg Selank? The bottle would then hold about 50 doses at 0.1 ml per nostril. Does that sound right?

Thanks for the details. I found a video that covers the whole process and now I have all the supplies ready.

I just watched that video too. It was straightforward and really helpful.

I'm away on a trip and trying to stretch what I have left. A shipment was delayed more than a week so I had to cut back to 200 mcg a day and it's still holding up okay. I'll be glad to get home and go back to the full dose for the cycle.

I've been dosing earlier in the day and haven't noticed much from NA Semax. Something feels different but I can't describe it and it doesn't seem useful so far. NA Selank feels noticeably stronger than the Semax but I'm still not finding a practical use for the effect. It sort of evens out mental openness I guess. Maybe I'm not anxious or ADHD enough to benefit or maybe I'm already more zen than I think. I'm not sure there's a strong reason to keep going.

I'm also ordering the NA version and looking forward to comparing it.

That matches what I've seen from other reports. It either makes a big difference or feels like nothing. For people who already have a strong anxiety response it seems to help gate that reaction. If anxiety wasn't an issue before then it probably won't do much.

I started Selank nasal earlier today. I accidentally added 1 ml of BAC first then added 9 ml of saline afterward. My sinuses feel dried out from the BAC so lesson learned. I chose Selank after reading about it and this thread gave me hope it might help with depression anxiety and negative thoughts from recurring flashbacks tied to childhood trauma. A couple hours after the first use I felt more mellow and ended up taking a nap which I needed because of insomnia. I'm hoping for good results.

Everyone reacts differently. I'm wondering if the 20-day Epitalon cycle I did earlier helped prepare me for these effects or if my brain was just low on BDNF and soaking it up. Epitalon is described as tuning the engine and Semax as giving it gas. I made the 300 mcg Adalank spray yesterday and tried it. It feels distinct from Semax more subtle but still pleasant. I'll keep both around.

I also had an odd feeling I couldn't describe and didn't really like when I tried regular use of Semax and Selank. Semax is known to help you feel clearer and more awake after poor sleep without acting like a stimulant. It makes me feel human instead of like a zombie when I use it that way.

I just received my NA Selank spray and will test it tomorrow then report back what happened.

Two pumps in each nostril comes to how many mcg?