What tipped the scale for you in your decision to stack your GLP with another or add in an amylin?

For me it started with tirz once a week. Around the five-day mark when the half-life was ending I got really hungry, so I split the dose into two shots a week to keep food noise down. Then I decided to try swapping one of those shots to reta instead of tirz to see if the glucagon effect would help as well. I like how tirz is working, which is why I haven't switched over completely.

I added 2 mg per day of tesa to 4-5 mg per week of reta for belly reduction and it worked well. I've finished the tesa and will stop unless the current 6 mg weekly reta dose stops controlling the belly. My situation may be different because of high-dose prednisone and hydrocortisone for disease management; those corticosteroids are known to cause weight gain and a large belly similar to Addison's.

I'm in maintenance on 7.5 mg tirz for six months. One persistent side effect is an extremely dry right eye. Dropping to 6 mg helped the eye but felt insufficient for maintenance, so I went back up. Recently I added cagri and lowered the tirz to see if that relieves the dry eye. It's only been two weeks and I'm adjusting both very slowly, so I don't know yet if it will work.

This weekend I added 2 mg of reta. I was on 10 mg tirz split 5/5 per week. I'm close to goal and wanted to try reta to see what it does. I expect less appetite suppression and the fat-burning third component. I'll see if I can shift dosing from tirz-heavy to reta-heavy. Plus I had some reta on hand and wanted to experiment.

I had been on 7 mg reta for a while and was happy with weight loss, but appetite suppression and food noise were very strong. I added 2.5 mg tirz as a cheaper way to calm food noise and appetite, and it's been great. It hasn't stopped me from getting calories in, but the small addition has nearly eliminated food noise.

I experienced unusual reactions while using tirzepatide, so I decided to switch over hoping the positives would stay but the negatives would vanish. It's only been a short time yet things look good up to now, keeping my hopes up.

I've been on 2.5 mg reta twice a week for a few months. Food noise disappeared right away and I lost 40 lb quickly. It's been slowly returning lately, though mainly for protein-rich foods, and I'm worried hunger pangs could lead back to other cravings. Some tirz is on the way so I'll add it slowly to see how it affects cravings. I'm also ten weeks into 2 mg tesa daily hoping it would speed up visceral-fat loss, but results haven't been dramatic.

Yes, I know the feeling very well. Thanks for your input.

I was happy on tirz at 2.25 mg but weight loss eventually slowed to nothing. I read about tirz fatigue and anhedonia at higher doses and saw some people stacking reta instead; they seemed happier, so I tried that rather than going up. I started very low at 0.5 mg and added more slowly. The only side effects were occasional skin crawling or sensitive spots that went away. It worked well for weight loss, and the tirz still keeps food noise away.

I tried adding 1 mg reta while dropping tirz from 10 mg to 7.5 mg. I was in an autoimmune flare and feeling really bad overall, and it didn't go well, so I'm back to tirz alone at 5 mg every four days or so. The main issue was severe fatigue, though I couldn't tell if it was from the tirz, the flare, or both. On the 5 mg doses I have normal energy and can eat again, which is a win. I'm still losing about 2-3 lb a month and nearly at goal.

One caution: I've read others say reta doesn't suppress food noise as well. If you need or want that suppression most, stick with tirz. I take 7.5 mg tirz on Friday and 4 mg reta on Tuesday as a mid-week booster. I added reta because I didn't want to titrate tirz higher and I like its fat-burning qualities. As I near goal it looks like I won't need more tirz and will probably stay steady on reta.

I'm looking forward to learning about the choices made by others. Appreciate the contributions provided earlier. Taking a ten milligram dose of tirz works well for me. Hearing explanations for combining with reta or cag, along with their dosing schedules, seems worthwhile. Grateful for the replies received. Much more progress needed on weight loss, and the shared knowledge helps a lot.

I had been maintaining on 12 mg reta, but after starting a steroid cycle that became unworkable and I was eating well over target on many days. I raised reta to 24 mg, which balanced the steroids enough to maintain weight, but slow loss was still hard. After a couple months I dropped back to 12 mg and added an ancillary I thought would help. That has worked better so far and I've been able to cut weight since the change.

Decisions feel driven by emotions over logic for me. Using a small amount of tirz starting in December. Reaching a standstill led me to introduce reta gradually rather than raising the tirz amount, for no clear reason. That made a difference. There have been weeks without any tirz. Earlier today the remaining contents gave 2mg tirz along with 2.5mg reta. Nearly three weeks had passed from the previous injection. Weight isn't coming off currently, perhaps from insufficient food intake. Years spent attempting smaller portions mean I can't consume anything without feeling hungry. This creates an issue : /

I just completed my third year on this. Losing the 110 pounds took me two years. Maintenance has been going for a year. I'm still using 10 mg Tirz, 2 mg Sema, and 2 mg Cagri, injected once a week or sometimes after eight days. Appetite control is something I keep pursuing, and the combo does the job for me. Constipation used to bother me but has gone away on its own, with no changes made. Feeling cold was a problem before adding Cagri, but now it helps keep me warm.

Last year around the start of a trip I felt awful for a whole day after my third tiny amount of Cagri. It could have been unrelated but I quit anyway. Later I added Survo which has worked out well and brought me to my target. With a fresh target in mind I'm now getting set to raise the Survo amount following this pattern of Tz ten every six days paired with Survo one point five every six days but shifted three days apart.

Back in February I began with 2.5 milligrams of Tirz. By May my progress had stopped. Even though that medication left me with barely any desire to eat, the numbers on the scale refused to drop. I avoided raising the dose further because I was nearing total dislike of food. Plenty of users here noted that Reta leaves hunger mostly untouched, so I tried adding a small one-milligram amount of it partway through the week. After doing so the weight began to drop once more. Early in August hunger returned, which made me raise the Reta amount to 1.5 milligrams.