Trying Retatrutide for Weight Loss Plateau and Comparing Options

8 replies5 peopleJun 22, 2026☆ Follow

Summary

Should I stick with retatrutide for my weight loss plateau and binge eating patterns or switch to semaglutide or tirzepatide?

The original poster started retatrutide at 2 mg while dealing with inconsistent eating habits and digestive issues. Other users shared their experiences with retatrutide, tirzepatide, and semaglutide, noting varied side effects and appetite changes. Most advised giving retatrutide several months and dose adjustments before switching. Individual tolerance differed widely even within families.

What this discussion establishes

Retatrutide helped some users eat normal portions and reduced hunger without constant food thoughts
Semaglutide caused severe nausea and inability to eat for one user, leading to discontinuation
Constipation appeared mainly during dose increases and was managed with enzymes, miralax, and hydration
Effects can wane toward the end of a weekly dose for some people
Retatrutide is viewed as more effective than tirzepatide or semaglutide but potentially with more side effects

Still open

How long any of these medications should be continued long-term for sustained results

Nothing here is advice.

8 replies · 5 people

QuietQuill34archiveopening postJun 22

I'm trying to lose a bit of weight from 194 down to 180. I work out regularly and usually eat pretty well, but I have a mixed relationship with food and sometimes binge or skip meals entirely. I also deal with stomach and gut problems. I started retatrutide at 2 mg hoping it would help me move past my current plateau. I've read various threads with conflicting details on dosing and side effects, and I'm still wondering if semaglutide or tirzepatide might suit me better, though it seems like everything comes down to trying things out.

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GreyAlder39archiveJun 22

How long have you been on this amount and how frequently are you injecting? One shot alone won't show much. Check dosage charts and trial references in the usual reference spots for more guidance.

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SlowSparrow49archiveJun 22

It depends on what you're dealing with. You sound a lot like me, where I don't graze constantly but tend to eat large amounts when I do sit down. I chose retatrutide at 1.5 mg every three days and it has let me stick to normal serving sizes. My wife started tirzepatide and reported she stopped thinking about food at all, which might not match your pattern of sometimes overeating and sometimes eating almost nothing. My daughter used semaglutide when she was younger and it worked but left her quite ill, so we stopped after reaching 1 mg. She's now on 4 mg tirzepatide split twice a week and doing better. Give retatrutide at least a couple of months before judging it.

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QuietQuill34archiveJun 22

↳ replying to @GreyAlder39

That was my first injection, so I expected it would take regular use to notice changes. So far I haven't run into the diarrhea or nausea that others mentioned, which is a relief. Thanks for pointing me toward the reference site, it's already been useful.

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QuietQuill34archiveJun 22

↳ replying to @SlowSparrow49

Thanks for the input, that makes sense since I just began. I was second-guessing after reading more threads with different experiences. Sorry your daughter had such a rough time with semaglutide. A friend of mine had a similar bad reaction to tirzepatide at the same dose your daughter used. Everyone reacts differently, and you nailed my eating pattern, so staying with retatrutide for a few months to test it out feels like the right move.

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SlowLedger31archiveJun 22

↳ replying to @QuietQuill34

I usually try a full vial or two at the daily dose before deciding if something works. I went through an entire SS-31 cycle and wasn't impressed. Retatrutide at 2 mg hit me hard at first, and the feeling has changed over time especially with intense workouts. Appetite suppression is lower now but hunger and food noise are almost gone and I fill up quicker. If I inject on Monday the effects start fading by Saturday. When I went up to 4 mg I had bad constipation. I've lost 43 pounds but recently stalled. A family member barely eats on it with almost no side effects and keeps losing steadily without constipation. I'd give it a real chance before stopping.

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QuietQuill34archiveJun 22

↳ replying to @SlowLedger31

One thing I'm curious about is the constipation problem. Does it happen regularly every week or mainly when increasing the dose? Thanks for the advice, I'll follow it.

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SlowLedger31archiveJun 22

↳ replying to @QuietQuill34

It only happened once and rated about a five out of ten. I started a digestive enzyme that helps. Whenever I feel things slowing down or feel sluggish I take a few nights of miralax. I also make sure to chew food well and drink plenty of fluids. The calculation says I should be taking in more than a gallon daily, and I notice the difference physically when I don't keep up with it.

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CopperSignal27archiveJun 23

↳ replying to @QuietQuill34 (opening post)

It's far too soon to consider switching. Retatrutide is currently the strongest option available for obesity, so if you're starting it you should give it a proper test for effects and side effects over several months and with some dose increases unless side effects become unmanageable. Since this may be something used long term it's worth finding out how well it suits you. Retatrutide and tirzepatide are fairly similar, with retatrutide slightly stronger but also slightly more likely to cause issues. Semaglutide tends to have more side effects and less effectiveness, so there aren't many reasons to choose it over the other two.

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