PCOS, Tirz & Reta

4 replies5 peopleAug 22, 2026☆ Follow

Summary

PCOS experiences switching between tirzepatide and retatrutide or using both for weight loss and cycle regulation

Users with PCOS report slower weight loss on these medications compared to metabolically healthy people. One person found retatrutide more effective only after reaching 8 mg and recommends titrating higher. Another shared that tirzepatide quickly restored regular menstrual cycles and supported pregnancy. The recent rename to PMOS is noted as making doctors take the condition more seriously in some cases.

What this discussion establishes

Retatrutide worked better for one user only after 8 mg, with suggestion to titrate monthly up to 12 mg
PCOS is described as a metabolic disorder now called PMOS, leading to slower weight loss on GLP-1 meds
Tirzepatide restored monthly cycles in one case and enabled pregnancy after years of irregularity
Dosing tirzepatide every four days is suggested to overcome stalls due to its half-life
Name change from PCOS to PMOS appears to influence how seriously some doctors treat the condition

Nothing here is advice.

4 replies · 5 people

WarmLedger68archiveopening postAug 22

Hi there, I'd like to connect with women managing PCOS who have tried either of these two options. My partner deals with PCOS and started on one of them several months back. Right now she's at six milligrams each week, yet the pounds are coming off gradually—just ten in total up to now. From what she's read, the alternate medication seems to show stronger early progress in some PCOS situations. We're thinking about whether beginning with that one and then moving over when progress stalls, or combining them, has helped others in similar spots. If you've dealt with PCOS and tested out these methods, what were your results like? Did making a change lead to better outcomes?

Like Same experience Reply

SteadyAnchor13archiveAug 22

I have PCOS and have tried both. Reta ended up working better for me, though only once I got to 8 mg. Keep increasing the dose each month until you reach 12 mg. PCOS is a metabolic disorder, now even called PMOS. People with metabolic issues like PCOS or diabetes tend to see big health gains on these GLP meds but usually lose weight more slowly than those without such conditions.

Like Same experience Reply

PatientHarbour28archiveAug 22

PCOS is now called PMOS. The name change actually matters. It is odd, but I am already hearing that a few doctors are treating PMOS more seriously than they ever treated PCOS. Sometimes the new name makes a difference.

Like Same experience Reply

IronLedger71archiveAug 22

↳ replying to @WarmLedger68 (opening post)

Tirz should be taken every 4 days. The half life is 4-5 days so dosing it more often should help break the stall.

Like Same experience Reply

PlainQuill53archiveAug 22

My wife has PCOS, now apparently called PMOS, and used to have only one or two periods a year. When we decided to try for a baby I first spent about a year addressing my own issues while attempting to time things with her infrequent cycles. Once I had things in good shape she started on tirz and almost right away her cycle returned, and within about four months she was pregnant. Now that the baby is here she is back on tirz and her cycle is regular again every month.

Like Same experience Reply

Related discussions

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.