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Anybody still doubting their success long term?

41 replies32 peopleMar 2, 2026☆ Follow
Summary

Will weight lost on GLP-1 drugs like retatrutide stay off long term or return once the medication stops?

Users share repeated past cycles of loss and regain from diets and express ongoing doubt, yet many now see these medications as changing body chemistry in a lasting way. Most plan to continue at reduced maintenance doses indefinitely rather than stop completely, often pairing the drug with new habits around food and movement. A few intend to test coming off after reaching goal while others treat obesity as a chronic condition requiring ongoing treatment.

What this discussion establishesWhere people disagree

Whether users should commit to indefinite use or attempt to discontinue after habits are established and goal weight is reached

Still open

How well weight stays off for those who eventually stop the medication entirely

Nothing here is advice.

41 replies · 32 people
GreenLantern78archiveopening postMar 2

I have not reached my target yet but have already dropped a good amount again. Like many others I have tried lots of diets before, lost weight, then put it all back on along with the usual guilt. What makes anyone think this round will hold up over time while the medication continues?

LevelFenwick52archiveMar 2

That worry has definitely occurred to me too. I have tracked calories for more than a year now, not counting the eight months I did back in 2020. Between 2020 and 2021 I went from 240 to 185 pounds just by logging everything and never going to a gym. When I quit tracking I climbed back to 225 and stayed there. Early last year I added the gym five days a week and dropped to 190 pounds of leaner muscle by early 2026. Because I already built those habits I see the medication as something extra on top of them, not something that takes their place. It has made a big difference in the short time since I began.

SteadyTimber49archiveMar 2

I know I would regain quickly if I stopped. I have white-knuckled diets before and watched the weight return the moment my focus slipped. I expect to stay on a low dose for a long time. Right now I am at 5 mg and roughly ten pounds from goal. Once I get there I will lower the dose and adjust until I find the right level, but I have come to terms with it probably being a permanent part of my routine.

ClearBeacon24archiveMar 2

I am ready to keep using it for the rest of my life and have enough on hand for ten years or longer.

NorthCompass62archiveMar 2
↳ replying to @GreenLantern78 (opening post)

Hope and belief. Without hope I would not have started a glp at all. Belief comes from watching the changes show up on the scale and in the mirror. I hope the progress continues. I believe it can because this time I am making life changes I never managed or attempted in earlier diets, and those changes plus the glp should make the difference long term. I tell my players to trust the process, so I am trying to follow that same advice and put in the work. Plenty of us have been knocked down by failed diets, yet here we are getting back up with a different tool this time.

WarmMeadow92archiveMar 3
↳ replying to @GreenLantern78 (opening post)

After six months on tirzepatide and solid weight loss I asked myself the same question. I have yo-yoed my whole life. Around that time I was watching My 600-lb Life and noticed how many people still struggled even after bariatric surgery. That led me to accept that some of my weight issues might be psychological. I did some work on that side and now feel hopeful that ongoing glp-1 use plus the behavioral changes will finally make this time different.

WarmHarbour28archiveMar 3

This question probably is not aimed at me since I never lost a pound in sixty years despite trying. If it takes another sixty to put it back on that is fine. I am not going to stay on this forever. I could, but then I would never learn what happens if I keep going without it.

SharpTimber43archiveMar 8

Yes, at 54 I expect some kind of maintenance dose or a switch to something like tesamorelin. I am 5 foot 8, went from 190 to 168 in under two months. Looking back I was dosing too high and had minor side effects, but the results were so good I did not care. I lost noticeable muscle because it was winter and a shoulder injury kept me out of the gym. The plan is to heal the shoulder with BPC-157 and start lifting again if possible. If not I can still run, train legs, and work the core. Even after the loss I still have a residual belly. I am thinking of stopping or dropping the dose a lot and trying tesamorelin and ipamorelin to target the midsection. I am happy with the weight loss but wonder if anyone has found a good way to use tesamorelin for that area.

ClearBeacon24archiveMar 8
↳ replying to @SharpTimber43

Tesa takes months to show results. I ran it for almost four months and then switched to hgh with good results at a low dose given my age.

SharpTimber43archiveMar 8
↳ replying to @ClearBeacon24

Thanks. Would that be HGH 191, and did you combine it with anything else?

BlueAlder28archiveMar 8
↳ replying to @GreenLantern78 (opening post)

I am definitely worried and really hope this round is different. I lost the same amount on Atkins and stayed on it for ten years. In my view Atkins is very risky long term. You are not really losing fat, you are dehydrating it. Push it hard enough and one slip like a brownie and milk can show four pounds the next day because your body pulls every bit of fluid back into the fat cells. I have also lost weight counting calories only to regain it all and more. Once I dropped thirty pounds while working offshore with almost no company, then gained it back and extra when I came home.

GreyPebble34archiveMar 8
↳ replying to @SharpTimber43

What dose of Reta will you drop to when you add BPC and Tesa? I posted about running those three together a couple days ago. I am on week four of 2 mg and will move to 3 mg Monday. I just got some BPC and am considering Tesa too.

KeenCompass55archiveMar 8
↳ replying to @SharpTimber43

Tesamorelin does not target the subcutaneous fat in the midsection. It targets visceral fat around the organs.

CopperAlder25archiveMar 8

The issue is that we treat obesity as only a physical medical problem when it also has a big psychological part. Many patients should probably stay on GLP-1 inhibitors long term the way people do for high blood pressure or diabetes, adjusting doses as needed. Some might be able to stop, but for those with serious obesity the side effects of the medication are still better than the obesity itself.

LevelCinder55archiveMar 8
↳ replying to @SharpTimber43

I lost muscle on Ozempic and went back to the gym to try to limit further loss. A torn rotator cuff that was never fixed quickly reminded me of its limits, so I dropped any shoulder exercises. BPC-157 and TB500 did not seem to help. I switched to the elliptical and weights that avoided shoulders, then moved to Reta and added Tesamorelin. In the last few weeks I have started adding very light shoulder work. So far it is going okay. If Reta worked for you then a lower maintenance dose plus Tesamorelin could be a good combination. You may need to try different levels to see what fits. It sounds like you are heading in a good direction.

CopperAlder25archiveMar 8
↳ replying to @ClearBeacon24

What protocol did you use with the HGH?

SharpTimber43archiveMar 8
↳ replying to @LevelCinder55

Thanks for the reply. The light weights feel intimidating right now. I am not sure if the BPC is helping but I want to do everything possible because I feel like I have one chance to fix the shoulder. Your experience is reassuring.

BrightMeadow15archiveMar 8

I can talk about maintenance. After my first pregnancy I lost sixty pounds, forty of them pregnancy weight and twenty I had wanted to lose beforehand. It took three years of maintenance until we decided on a second child. I could not track every single day anymore. I settled on yellow and red zones with a five-pound buffer because of normal monthly changes. Yellow meant smarter snacks and smaller portions without full tracking. Red meant measuring and tracking again. I only hit red twice in three years. The person who came up with the zones set the red trigger so they would never have to diet longer than a month.

IronBramble31archiveMar 8
↳ replying to @WarmMeadow92

I have lived the 600-pound life and the struggle continues even after weight-loss surgery. The GLP-1 drugs have been the missing piece for me. I am optimistic they can keep the weight off. I have gone off three times and the weight returned right away. I only seem to need 2 mg of either Tirz or Reta or 1 mg of both to stay compliant and maintain. During loss I reached 10 mg of Tirz but 7.5 mg was the highest I could handle. Adding Reta let me drop the last twenty-three pounds in a month at just 4 mg. I do not plan to stop long term but think occasional cycling will help me keep appreciating it and not take my supply for granted.

ClearLedger45archiveMar 9

This really changes body chemistry in a way ordinary diets never do.

PlainThistle36archiveMar 9

If you had told me in January I would be down thirty-five pounds I would not have believed it, yet here I am at a personal goal I have not seen in six years. Another thirty-five would put me in the healthy BMI range and a weight I have not seen since middle school. I am scheduled for joint repair surgery so I will pause the GLP-1 for a couple weeks before anesthesia. I am more nervous about losing discipline and regaining than about learning to walk again. I will restart after surgery but fourteen days without it already feels too long.

CopperSignal27archiveMar 9

I have doubted my success many times given how often I regained before. Two things feel different now. At 57 the medical risks of regaining are much higher, and these GLP medications from research sources are available. I have followed the research for nearly forty years hoping for something that actually works without killing you, and it finally arrived. Thanks to the researchers who got it done.

BlueBramble59archiveMar 9

I feel confident I will keep a healthy weight. My goals are realistic and I plan to stay realistic as I age. I still have fifteen pounds to go and am taking it slowly so habits can strengthen. Once at goal I will lower the dose and find a maintenance level, probably for a full year to lock in the habits. After that I might try stopping but I am ready to continue long term if needed.

AmberMarble84archiveMar 10

I am a bit scared. My good habits have slipped some lately even though I am almost at goal. Mostly I worry that side effects like pancreatitis could make my long-term supply useless.

IronAlder42archiveMar 10
↳ replying to @ClearBeacon24

That is exactly how I feel. I have decided to treat my body kindly for however many years I have left. I accept obesity as a chronic condition and that ongoing treatment will help.

IronAlder42archiveMar 10
↳ replying to @PlainThistle36

I can only imagine how scary that feels and wish you the best with the surgery. I also wonder if anyone has gone through surgery without pausing the medication, based on updated guidelines from 2024.

PlainThistle36archiveMar 12
↳ replying to @IronAlder42

Thanks for the good wishes. I looked at both the old and new guidelines too. My doctor advised one week off to lower the risk of aspiration under anesthesia. My wife would feel better with two weeks, so I will pause for two. Surgery is still over a month away but the thought of possibly regaining or relearning to walk is already causing anxiety.

KeenWillow72archiveMar 14
↳ replying to @IronBramble31

It is great that you found something that lets you live without constant worry about food. It is also good that these options exist now.

AmberSignal57archiveMar 14

I think about this often. My plan is to have enough on hand for a maintenance dose long term so the changes I am making can become normal parts of life. I am doing meal prep and once my other hip is replaced I expect to be much more active. Age, hormones, Ehlers-Danlos, arthritis, and hip dysplasia all play a role, so addressing what I can is part of the plan right now.

SteadyLedger49archiveMar 14

I am not worried about regaining. My lifestyle has changed so much and I am happy to stay on peptides for the rest of my life. At 61 I am in the best shape I have ever been and feel great after losing more than half my body weight. My only regret is not starting fitness earlier.

PlainThistle36archiveMar 30
↳ replying to @PlainThistle36

Now down forty-two pounds with thirty days until surgery. I am pausing a lot of things and expect to be difficult for the next few weeks. None of it is strictly required but it seems like best practice. Today I stop DSIP after five weeks. Wednesday I pause KLOW and quit smoking. Friday is my last injection until after surgery. I am doubting myself a lot but have reached peak "whatever" mode. Open to any encouragement.

WarmAnchor49archiveMar 30
↳ replying to @SharpTimber43

Swim the crawl stroke. Get in a pool and work up to a mile. Your waist will shrink.

IronLantern24archiveMar 30

I have been at this on and off since I was twelve. I must have lost and regained a thousand pounds over the years. I have to keep it off this time because I already gave away all my fat clothes.

WarmMeadow92archiveMar 30
↳ replying to @IronLantern24

Same here on every point. I cannot regain or I will have nothing to wear. I have also lost and regained many times. When I started Zepbound my doctor said I could donate the fat clothes because I would not need them again. Based on the trial data he is probably right.

ClearKettle41archiveMar 30

I am feeling positive and using the time on Reta to figure out how I gained the weight and why it kept coming even when I ate clean. Hormones and constant under-eating probably played a role. When I reach target I want to test whether the dietary changes hold without the medication. I am not against continuing anyway because of the other benefits for metabolism, inflammation, food noise, and possibly cancer risk. It is more than just another weight-loss GLP-1.

SteadyTimber22archiveMar 30
↳ replying to @ClearKettle41

Great plan. There is very little solid information on maintaining after Reta. Keep us updated on how the dietary changes work out.

BlueSignal52archiveMar 30
↳ replying to @GreenLantern78 (opening post)

I have no doubts it will work for me, but I had to be honest about why I got here. I have yo-yoed since my early twenties, exercising and eating well just long enough to hit a goal then dropping any long-term plan. A few years ago I went from 280 to 210 and realized working out had to become permanent, not temporary. Three years of consistent training later that part feels solved. Diet was the part I kept failing at. I used to think I could offset bad eating with hard workouts. Occasional treats became more frequent and I gained twenty pounds in six months. Not owning a scale did not help. Reta is addressing the diet piece I never really fixed. I am not expecting fast results or trying to change everything at once.

SlowMarble98archiveApr 8

What gives me faith is what I see with my own eyes. I have been at goal since 2022. Never in my sixty-one years have I maintained a loss this long without constant struggle. Before this any time I reached goal I always started regaining ounce by ounce. I was never weight-stable until these last four years. I will take these peptides until I die.

WarmWillow50archiveApr 8

If I have twenty years left I do not want to spend them overweight and inactive, which would probably shorten those years anyway. After decades of yo-yoing and even after bariatric surgery I knew regain was possible. These GLPs plus some other peptide protocols have given me real hope that this can be sustainable.

SharpAlder41archiveApr 11
↳ replying to @GreenLantern78 (opening post)

I started building good habits before the medication, but seeing progress keeps me motivated. Will it be forever? I hope so, but right now I am just focusing on putting myself first more than I used to.

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