I have also lost some of the pleasure from eating. Now I eat because I need to, not because I am looking forward to something tasty. I hardly drank before, so I have not noticed any difference there.
My brother told me ahead of time that retatrutide would take away most of the pleasure from meals and drinking, leaving them as just social or routine things. He was right about alcohol. Even at a low dose after only a couple weeks, my usual pre-dinner drink feels like nothing but habit. The warmth and buzz are missing, so there is no point. I switched to an electrolyte drink instead. It is healthier and I will probably adjust, but it feels a little sad. Meals still taste good and I enjoy them, though I rarely think about food or feel hungry. Maybe people who lost interest in food had a stronger dopamine response to it before starting. I will still have a drink now and then at events, but not something I look forward to regularly. Does retatrutide make most people stop drinking? I guess this ties into the anhedonia side effect.