Is anyone doing a Reta + Tirz?

Same question from me. Reta leaves too much food noise still.

Why combine one peptide hitting GLP-1, GIP and glucagon receptors with another that hits GLP-1 and GIP? Seems like an easy way to pile on side effects instead of just raising the reta dose.

Reta every three days, then on the sixth day I add the tirz along with the reta.

Pretty much everyone I know is. I paused while waiting for surgery next week, but when I was actively losing and then maintaining I stacked both. On maintenance I used roughly 1 mg of each, spaced 72 hours apart, and it kept weight steady with minimal cravings.

Reta 5 mg on Monday and tirz 8 mg on Thursday. Planning to switch the days again at the end of the month.

Started tirz last October and worked up to 7.5 mg. Picked up a 60 mg kit of reta during a sale but only started it late January, planning to raise reta slowly while lowering tirz. So far tirz is down to 6 mg and reta has been at 6 mg for weeks. Fat loss continues and muscle holds steady on DEXA scans. Will finish the vial then reassess, possibly nearing maintenance by then.

Currently at 15.75 mg tirz plus 5 mg reta. Still had some hunger at 15 mg tirz but almost no side effects, so added a little reta rather than risk changing the tirz dose. Trying to hold onto a 54 % total loss. See little reason to run both unless already at max of one, and even then higher dose of the single one might be better. Tirz’s stronger GIP action could offset some reta nausea. If sides are fine then higher doses or adding cagri probably make more sense.

Also stacking, recently lowered doses after a three-week break because appetite vanished completely at first. Down 95-plus pounds and haven’t felt actual hunger in months, though I still want food. Using 6 mg tirz and 5 mg reta spaced three days apart keeps the weight dropping while still allowing fruit, vegetables and protein.

Can see mixing low amounts for people who have tried each separately to balance hunger control against sides. The two are similar but not identical, yet figuring out the separate effects takes time and is nearly impossible if started together. Low-dose mixing seems common but the reason is unclear. Also puzzled by claims that reta gives weaker appetite suppression than tirz, since the metabolic boost from reta does not appear large enough to explain greater weight loss if intake were truly higher.

Doing it too. Started with reta 2 mg on day one then tirz 2 mg on day four. Reta increased eating and sweet cravings, so now run reta 2 mg and add a little tirz every other week for appetite and inflammation control. Tried cagri but it did nothing for me.

ENT and neurosurgeon had me stop reta two weeks before surgery and wait at least two weeks after. Did not need it anyway because hospital diet was very restricted and I lost 8 lb in the ICU week, though fluid limits made it miserable. Even after discharge fluid was capped at 8 oz daily including water in food for two weeks. A cup of grapes equals 2 oz fluid, learned that the hard way but still dropped more weight.

From 15 mg tirz you could probably move directly to at least 5-6 mg reta with caution. No official swap guidelines exist, but 15 mg tirz roughly matches 8-10 mg reta for GI side-effect risk. After stopping high-dose tirz hunger will likely spike, so a tiny reta dose may not hold it. Without heart disease or diabetes, 6 mg reta is a reasonable starting point; side effects worse than 15 mg tirz would be unlucky. Slow titration is safest if time allows, but if binge risk is high then jump to 6 mg and add 2 mg every couple of days if tolerated, reaching 10 mg within a week.

Daily micro-dosing while titrating lets you spot sides sooner and avoid long clearance waits. Tried 7 mg the first week that way, now two months later at 8-10 mg weekly split with no issues.