CommunityDosing & Titration

Not noticing a difference on reta

34 replies17 peopleJul 24, 2026☆ Follow
Summary

Why am I not seeing weight loss or body changes when switching from tirzepatide to retatrutide?

Users switching from high-dose tirz to low-dose reta often report stalled progress for weeks or months while doses are adjusted. Some find tirz superior for appetite control and binge eating, while reta may require higher amounts to match prior effects; others note recomp without scale movement or increased hunger. Slow responders share frustration but suggest patience, gradual increases, or temporary calorie bumps to restart loss. Several emphasize that total GLP activity drops during transition and that individual response varies widely.

What this discussion establishesWhere people disagree

Whether to raise reta doses quickly despite side-effect concerns or remain conservative and patient during the transition

Still open

How long a plateau should be tolerated before changing strategy or returning to tirz

Nothing here is advice.

34 replies · 17 people
SteadyCompass88archiveopening postJul 24

Hey everyone. I've been on tirz for more than a year and stayed at 15 mg for some time. Switching to reta now, but after roughly a month I still don't feel any change. Right now I'm at 2 mg reta weekly plus 7.5 mg tirz on separate days. Weight has been stuck for a while with no loss or gain. It's discouraging to hear about big body changes from others while nothing seems different for me. I keep up with pole fitness and pilates three times a week. Mainly looking to connect with other slow responders to vent or get ideas for staying patient.

SteadyQuill55archiveJul 24

I had the same experience moving from tirz to reta and eventually gave up on the switch. Went back to tirz and just raised the dose instead. There's time later to experiment with reta, but not when I'm only a few pounds from goal and want to finish and settle. Reaching a useful reta dose after steady tirz can take months and might involve some regain, which I'm not ready to handle emotionally right now.

PatientAlder89archiveJul 24
↳ replying to @SteadyCompass88 (opening post)

I get it. I'm also a slow responder and have tried both, going up to 4 mg of each weekly. One week finally showed 3 lb down, then it came right back even though I'm barely eating and doing intermittent fasting plus daily exercise. Before that it took 17 days to drop a single pound. I probably need to keep raising the dose but already have almost no appetite and strong food aversion. Still have around 30 lb left after losing a bit over 20 lb in five months. Hope knowing it's not just you helps a little.

IronMarble78archiveJul 24

Reta is making me eat more food unfortunately.

PlainAlder11archiveJul 24

Reta worked really well for me. Never used tirz and didn't even know about it until I joined here.

SteadyCompass88archiveJul 24
↳ replying to @SteadyQuill55

I'm worried reta won't work the same way tirz does for me and I don't want to lose more muscle. I've heard reta doesn't control appetite as strongly, which is what made tirz so helpful with my binge eating history. Maybe I just need to keep going slowly and raise the reta dose. Hope you can try it again later and add it to tirz.

SteadyCompass88archiveJul 24
↳ replying to @PatientAlder89

It's really helpful to hear I'm not alone. I also have about 30 lb left after dropping 55 lb on tirz alone. I hoped adding reta would break the plateau but it feels like it's doing nothing so far. Maybe fat is coming off and muscle is going on, but I can't tell yet. It's only been a month so perhaps I should stay with it and increase the dose.

LevelThistle44archiveJul 24
↳ replying to @SteadyCompass88 (opening post)

You've been at 15 mg tirz weekly for a while yet seem surprised that 2 mg reta isn't doing much. You're frustrated about the plateau but have cut your main glp amount in half while adding only a beginner dose of something else. Might help to adjust what results you expect right now.

SteadyCompass88archiveJul 24
↳ replying to @IronMarble78

Same here, I'm eating more too. That's exactly why I plan to keep tirz in the mix and alternate with reta to keep appetite in check.

SteadyCompass88archiveJul 24
↳ replying to @LevelThistle44

I understand that. My hopes were really high after seeing friends respond strongly to reta and mostly stop tirz. I need to work on patience with myself. My usual pattern is to quit if I'm not good at something right away. I was mainly looking for encouragement and people to talk with about sticking with it instead of stopping. I started reta low because of other meds that affect heart rate. Planning to raise it again this week since weight has been flat for six months even on tirz.

IronTimber44archiveJul 24

Last year on tirz I lost 17 kg in eight months and only reached 7.5 mg before lowering. Took a break for a few months. This year I've been on reta for four and a half months and am about to move from 8 mg to 10 mg. Still no real drop in food noise and only 2 kg down, now on a plateau. Exercising daily and eating well. Will stay at 10 mg for a month or two then maybe go higher. Depending on results I might return to tirz or try both together. It's all trial and error so far. For some people tirz might suit them better than reta, especially if appetite control matters a lot.

LevelThistle44archiveJul 25
↳ replying to @SteadyCompass88

Do you track heart rate with a watch, ring, or similar device? I went the other way and increased faster, but overall results have been good so far.

BlueTimber11archiveJul 25
↳ replying to @SteadyCompass88

Most people notice muscle gain because they see clear strength increases in the gym. How is your strength training going? Are you lifting noticeably heavier weights?

PatientPebble79archiveJul 25
↳ replying to @SteadyCompass88

Since 2 mg has been fine for a month you could probably raise it a little and see what happens. Starting low was smart even after high-dose tirz because the drugs are different and you avoided big side effects. I think of tirz as the appetite tool and reta as the weight-loss tool. Maybe a bit more of both would help right now. Congrats on the 55 lb. The six-month plateau might actually be useful long-term because your body had time to adjust to the big change. It could just need a pause before another push. Good luck.

KeenMeadow10archiveJul 25
↳ replying to @SteadyCompass88

I lost 40 lb on 1 mg or less of sema. It took getting to 8 mg of reta before weight loss picked up again, and now I'm at 10 mg. People coming from another glp often need higher amounts of reta. I'm glad I waited until the price was lower.

CopperSignal27archiveJul 25

Total glp activity has gone from 15 mg tirz down to 7.5 mg tirz plus 2 mg reta, roughly 10 mg tirz equivalent, so effects should be weaker than before. You probably won't notice much until reta is raised quite a bit, but I understand not wanting to push it fast and risk side effects. Small frequent doses can be a safer way to increase quicker, like 1 mg every two days for a week then 1.5 mg every two days, but check a glp plotter first and slow down if sides appear.

KeenLedger22archiveJul 25
↳ replying to @IronTimber44

If weight has stopped dropping then calories are still too high, no matter the exercise or healthy eating.

KeenPebble33archiveJul 25
↳ replying to @SteadyCompass88 (opening post)

You've already lost 27 percent of body weight and are using low doses of both. Tirz isn't usually very effective past 25 percent loss, so moving to reta makes sense. Go all in on 12 mg reta and drop tirz. Loss should stay slow but continue. Watch food intake carefully if aiming past 30 percent total. Even 5 lb a month now would be solid progress.

CopperSignal15archiveJul 25
↳ replying to @LevelThistle44

What starting dose of reta makes sense after long-term 15 mg tirz?

LevelThistle44archiveJul 25
↳ replying to @CopperSignal15

I was on 5 mg tirz when I switched. Started reta at 1 mg and took six doses the first week for a total of 7 mg. There's an earlier post from April with more details if you want to look.

KeenMeadow10archiveJul 25
↳ replying to @LevelThistle44

My shotsy never showed overlapping graphs like that. And now the app is dead.

LevelThistle44archiveJul 25
↳ replying to @KeenMeadow10

What's dead? I just exported that PDF today.

KeenMeadow10archiveJul 25
↳ replying to @LevelThistle44

The shotsy app stopped working. It crashes every time I open it. A friend pulled my data but the nice charts are gone. Tried on three different devices.

LevelThistle44archiveJul 25
↳ replying to @KeenMeadow10

Maybe have him export the JSON, delete the app, reinstall, then import again. It claims iCloud backup but I still download the JSON regularly plus CSV and PDFs for charts.

ClearHarbour23archiveJul 26
↳ replying to @PatientAlder89

Not an expert but when I hit a plateau in the past, eating more calories for a week then returning to the usual amount often restarted loss. Don't go overboard, just allow a bit more for one or two weeks.

SharpAlder96archiveJul 26
↳ replying to @ClearHarbour23

I also find that after long calorie restriction, heavy training, and staying healthy overall, loosening up for a week or so can restart things. The body seems to relax and realize it isn't being starved.

PlainKettle14archiveJul 26
↳ replying to @IronTimber44

Similar experience. 5 mg tirz got me 20 kg down with no exercise. Switched to reta at 4 mg now, added exercise, strength work, and good protein, yet scale barely moves. Body recomp is visible and clothes fit better but weight stays the same. Not going back to tirz but might add it if 8 mg reta doesn't give better results.

ClearHarbour23archiveJul 26
↳ replying to @SharpAlder96

Exactly. One of the rare times the usual advice to live a little actually fits. It usually annoys me because that's how I got here in the first place.

PatientAlder89archiveJul 26
↳ replying to @ClearHarbour23

Thanks, I'll try that. Eating is already really difficult and nothing sounds or tastes good.

ClearHarbour23archiveJul 26
↳ replying to @PatientAlder89

Not sure about the data on lowering doses but it might be worth checking.

PatientAlder89archiveJul 27

Does it get worse when the dose goes up?

PlainAlder11archiveJul 27
↳ replying to @PatientAlder89

Does what get worse, the appetite suppression? That message was meant for a different thread. Too many tabs open I guess.

PatientAlder89archiveJul 27
↳ replying to @PlainAlder11

I mean side effects like appetite loss or mild nausea. I probably need to raise the dose to restart loss but already struggle to eat anything.

PlainAlder11archiveJul 27
↳ replying to @PatientAlder89

I had occasional heartburn when I started and didn't feel like eating, got full and bloated quickly. All that faded after a few months except the fullness. Appetite suppression is still there but in a positive way. No nausea or the other sides people mention. My wife had the same pattern on the same doses. Sleep trouble isn't from reta for me, it's a mental thing where I wake at 4:30. Still get six and a half to eight hours. Where are you at with dose and weight loss?

PlainAlder11archiveJul 27
↳ replying to @PatientAlder89

As I said, eating isn't hard but I fill up fast and never rush to eat. My wife tells me to eat more and get protein in. Used to finish a whole chicken breast or steak easily. Now we split them in half.

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