CommunityFood & Appetite

Peptides and Fasting question

7 replies5 peopleJan 11, 2026☆ Follow
Summary

Do zero-calorie artificially sweetened drinks interfere with fasted-state peptides like GHRP-2 by triggering an insulin response?

The thread concludes that artificially sweetened zero-calorie beverages cause minimal or no insulin response and behave like water in glycemic and endocrine measures. Participants report continuing their usual sugar-free sodas and teas around dosing without apparent issues. Electrolyte supplementation during longer fasts is discussed but leads to side arguments about sodium needs and sources. A linked meta-analysis is cited as supporting evidence that postprandial responses remain comparable to water controls.

What this discussion establishesWhere people disagree

Whether additional sodium intake is advisable or excessive during fasting periods

Nothing here is advice.

7 replies · 5 people
BlueBeacon12archiveopening postJan 11

For peptides that need to be taken fasted, especially ones like GHRP-2 where food can trigger insulin and weaken the effect, I'm wondering if that includes skipping zero-sugar drinks. I usually have sugar-free sodas or teas in the morning or before bed and figured the lack of calories or sugar meant they wouldn't interfere, but maybe they still cause some insulin response. I'd switch to water if it matters, though I'd rather keep the drinks if they don't make a difference.

AmberCompass48archiveJan 18
↳ replying to @BlueBeacon12 (opening post)

From what I understand drinks with no sugar or calories at all won't interrupt a fast. Even items around twenty calories probably won't end it either. Electrolyte packets have been the most helpful option for me during those times. When doing a two day fast especially while on glp1 meds I end up needing extra potassium sodium and magnesium and those packets contain artificial sweeteners as well.

GreenBramble19archiveJan 18
↳ replying to @BlueBeacon12 (opening post)

Drinks made with sugar substitutes appear to trigger hardly any insulin activity at all. The combined research review attached here indicates blood sugar readings along with several digestion related hormones end up matching those from plain water after intake.

AmberCompass48archiveJan 18

I've checked out tons of options and save the pricey electrolyte mixes strictly for fasting periods so the cost doesn't bother me.

BlueTimber78archiveJan 18
↳ replying to @AmberCompass48

That automated reply on eating habits matches a doctor's level of uselessness pretty closely. The push for citizens here to add extra salt comes across as necessary as me sprouting another skull.

SteadyQuill55archiveJan 18
↳ replying to @BlueTimber78

It doesn't seem right to complain if the extra head had awareness of its own. That would give twice the thoughts plus another perspective on any uncertain move. Plus someone else could take over incoming calls when you'd rather skip them even though it's necessary. Naturally this requires sorting out which one counts as the main one versus the backup and that could get tricky.

BlueBeacon12archiveJan 18
↳ replying to @GreenBramble19

I'm really pleased since this lines up perfectly with what I wanted. It's nice to know the details draw from lots of different research too. Appreciate it!

BlueBeacon12archiveJan 18

It worked fine on my end so the download finished without trouble.

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