CommunityFood & Appetite

Reta was great …but what went wrong?

10 replies7 peopleJan 16, 2026☆ Follow
Summary

Why did weight loss stall on retatrutide after adding ipamorelin?

One user lost steadily from 314 lb to 277 lb on reta with strict diet and sleep, then gained 9 lb and plateaued after a short break and starting ipamorelin; appetite suppression also weakened at higher doses. Others point to ipamorelin causing water retention and hunger that can last weeks. Suggestions include pausing the peptide, adding tesa, or focusing on exercise and protein.

What this discussion establishesStill open

exact reason for the month-long plateau

Nothing here is advice.

10 replies · 7 people
RustWillow38archiveopening postJan 16

I began dieting in August at 314 pounds and started Reta in early October at 307 pounds. I kept to zero sugar, two meals daily with eggs in the morning and chicken salad in the afternoon before 5:30 pm, plus at least seven hours of sleep on a steady schedule, NAC in the morning and glycine at night. The scale moved downward overall and reached 277 by December 15. I took a week off and added ipamorelin, then saw a nine-pound gain two weeks later and have stayed near 284 for a month. Appetite control at 8 mg now feels weaker than it did at 2 mg back in November.

BrightBeacon35archiveJan 16

The ipamorelin is likely the culprit. Most growth hormone peptides cause extra water retention and raise hunger, so the extra pounds could be water plus a few more calories eaten.

RustWillow38archiveJan 16

Hunger did increase, which was my first guess. I raised reta from 4-5 mg up to 8 mg expecting it to offset that, yet the scale stayed flat for a full month after working well for the prior two and a half months.

SlowWillow48archiveJan 16

How long have you been on ipamorelin? Reports from others say the water weight it adds can linger for a while before dropping off. You might try stopping for a week or two to check for change. How much exercise are you doing?

RustWillow38archiveJan 16
↳ replying to @SlowWillow48

I began ipamorelin on December 23, so three weeks ago.

AmberCompass48archiveJan 17

What dosing schedule are you using with ipamorelin? I have some but have not started yet.

BlueMeadow87archiveJan 17

I use a 5 mg/5 mg blend of cjc 1295 and ipamorelin. One daily dose works, either morning before a workout or 30-60 minutes before bed after a two-hour fast, then wait half an hour before eating. My dose is 200 mcg. The cjc signals the pituitary to produce GH and the ipamorelin triggers its release.

RustWillow38archiveJan 18
↳ replying to @SlowWillow48

Ipamorelin started December 23 at 250 mcg morning and night, five days on and two off, stacked with tessamorelin.

SlowBramble73archiveJan 18
↳ replying to @RustWillow38 (opening post)

I also began in October and followed the same gradual increase used in the trials. Exercise matters a lot. My body-comp scale showed subcutaneous fat dropping while visceral fat stayed put until I added tesa twice daily before bed; visceral then fell from 20 to 16 in about six weeks. Hunger from the IGF peptides has not been an issue at 8 mg reta. I keep protein and healthy fats high and add carbs on training days when energy is low. Some stack cagri with reta to break stalls. At 8 mg reta seems to work well for holding weight steady.

LevelPebble75archiveJan 18

GH peptides are great but I ran IPA/CJC cycles only after finishing my weight loss. They always made me very hungry. I would stop the ipamorelin for now and restart it once you are close to your goal weight.

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