CommunityFood & Appetite

Too much appetite suppression?

4 replies4 peopleOct 10, 2025☆ Follow
Summary

How to handle excessive appetite suppression and related side effects while using tirzepatide for binge eating control?

The original poster reports strong appetite loss making it hard to hit macros or even 1000 calories on rest days, plus adrenaline surges and elevated heart rate after starting at 2.5 mg. Replies note that heart-rate increases are expected with these compounds and advise lowering the dose or spacing injections when sides feel too strong. One participant attributes the fatigue and low energy to calorie reduction rather than adrenaline. The thread ends with a suggestion to halve whatever dose has already been tried.

What this discussion establishesWhere people disagree

Whether the reported sensations are true adrenaline dumps or simply tiredness caused by low energy intake and the drug itself

Still open

What to do with unused vials or whether switching compounds would be better

Nothing here is advice.

4 replies · 4 people
RustKettle95archiveopening postOct 10, 2025

Hi, I bought some tirz recently and just took my fifth weekly shot. Started at 2.5 mg and even tried half that amount, yet the appetite control is stronger than I can handle. As a retired physique athlete I need to keep food choices and macros on point, but I feel sick when I try to eat and the desire for food just isn't there. On days without lifting I can hardly get to 1000 calories. I've also had adrenaline surges that probably make the suppression worse. My resting heart rate moved from the mid or high 50s up to the low or mid 60s and can jump into triple digits after stairs or feeling anxious, which adds to my health worries. I picked tirz hoping it would help with binge eating, but now I'm thinking about trying reta instead and wondering what to do with the rest of the vials.

BrightMeadow15archiveOct 11, 2025

Maybe a bit more reading on the topic would help. I understood that a modest rise in heart rate is a recognized effect of tirz and is definitely seen with reta. At a partial dose reta added a full 10 bpm for me, which comes from the extra calorie burn it causes. Bodybuilders seem to like reta but anyone starting it should know it will push heart rate higher. All three are GLP-1 agonists yet that is only part of the structure for tirz and reta. If sides are this noticeable then lowering the dose makes sense. The studies settled on 2.5 mg to begin and 5 mg as the usual treatment level, so if 2.5 mg already feels like too much then it probably is. Some people stay at 2.5 mg and still reach their goals. These compounds need about four weeks to reach steady levels, so skipping a week might speed relief if you're struggling.

RustKettle95archiveOct 11, 2025
↳ replying to @BrightMeadow15

Thanks for the reply. I already knew about the heart-rate increase and don't mind that part much, but the adrenaline surges are what bother me. I'll try spreading the shots out more while using only half of the 2.5 mg dose and see how it goes.

PatientCinder59archiveOct 11, 2025
↳ replying to @RustKettle95 (opening post)

Those sensations aren't adrenaline dumps. They are tiredness and low energy that come indirectly from eating far fewer calories and directly from the peptide. Most people using tirzepatide probably notice something similar to some degree.

RustSparrow16archiveOct 17, 2025

I realized what I was using turned out excessive so I went back to the smallest amount I had tried before and cut that in half either with smaller shots or longer gaps between them.

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