CopperSignal27

archive participant · first seen Aug 28, 2025 · last active 1d
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Depression, and Semax, and SSRIs, oh my!
The contraindication concern seems overstated without knowing the exact heart issue. I'm on tricyclics despite heart disease. Avoiding bupr…
Jul 25
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Reta+Tirz+Cag long term super stack
No published work exists yet on tirz above 15 mg, reta above 12 mg, or any combinations. One trial is testing higher tirz doses but results…
Jul 25
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Those combining Reta and Tirz
This does not match how drugs work. Receptor response to an agonist follows a stretched S-shaped curve. Retatrutide data show clear weight-…
Jul 25
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Lupus flare? A virus?
Do you think they'd proceed with the surgery if it's a lupus flare or a virus? Maybe a simple blood test checking inflammation levels such …
Jul 24
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Weekly peptides for chronic pain relief?
GLPs probably have the strongest real evidence for helping chronic pain, but she is already using one. Human trial data for the others is m…
Jul 24
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Tirz + Cag stack
If a solid trial of Cagri doesn’t get you moving, Elora might be worth looking at. No one really knows yet how it performs if Cagri didn’t …
Jul 24
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Reta Titration
With only about 15 pounds to lose and body fat near 20 percent, staying conservative makes sense. For people who are not significantly over…
Jul 24
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What to add?
I'm attempting to clarify for the thread starter the reason behind those unhelpful replies. Lacking the personal details I asked for previo…
Jul 23
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Roche's new GLP-1, Enicepatide.
Very similar to tirzepatide in many respects except it is a biased agonist toward cAMP at both GLP-1 and GIP, while tirzepatide is biased o…
Jul 23
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Those combining Reta and Tirz
I have been on 15 mg tirz and 6 mg reta for about a year and recently added 0.5 mg cagri. This is for lifelong severe obesity that is now i…
Jul 22
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Reta Titration
Half a milligram is quite cautious. Some here have had rough starts even at the 2 mg level the company suggests. How fast you move depends …
Jul 22
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Is 4lbs in 2 months not good?
Of all the GLP medications I have tried only semaglutide produced that general low-grade unwell feeling, similar to a mild virus. I do not …
Jul 22
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Does anyone know why reta looks less effective for weight loss in this research paper?
Without rereading the whole thing, I'm pretty sure they didn't pull in the newest reta results that showed 29 percent loss at 12 mg over 72…
Jul 22
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Does anyone else have this weird experience?
I've noticed that using bigger amounts together with extra versions of these meds cuts down on my appetite and stops me from wanting to con…
Jul 22
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Anhedonia from retatrutide doses and options for mood recovery with tirzepatide or TRT
It is interesting that tesofensine helped your anhedonia. It has not been studied in humans as an antidepressant but chemically it acts lik…
Jul 22
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What's your favorite workout/running shoes?
I mainly walked to improve my fitness level, and that approach succeeded for me. At my starting weight of 115 kilograms, even brief strolls…
Jul 21
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Does anyone else have this weird experience?
Before those treatments I would get hit with overwhelming cravings soon after tasting just a little of the richer or faster-digesting items…
Jul 21
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Eczema onset from Reta
It will be difficult to confirm any link to the compound because skin rashes occur often for many reasons. Allergic-type reactions to these…
Jul 21
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GLP1 in pregnancies
Several studies have looked at women who took GLP drugs early in pregnancy before realizing they were pregnant and then stopped; those case…
Jul 21
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Total Cholesterol Normal but Triglycerides high?
Are you carrying extra weight? Starting reta two months ago suggests you had weight to lose. The starting A1C was mildly elevated and the t…
Jul 21
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