Reta, still no effect

The impact builds with every injection and it can take four or five weeks before the full effect appears at that amount. You can look at this chart to see how the levels add up over time.

I would not stress much yet because responses to these medications differ a lot from person to person. Since most people use them for long-term weight issues, a few weeks will not change the overall picture. If you feel zero effects and zero side effects you could move the dose up a bit faster, provided you are not elderly or dealing with serious health conditions, but I would keep the twice-weekly schedule so levels can drop quicker if nausea suddenly appears.

I agree that raising the dose makes sense, especially since some studies began people at 2 mg. You could try 1 mg twice a week for now. Taking the full 2 mg at once affected me quite strongly, so spreading it out the way you have been doing still seems wise.

From everything I have gathered, 1 mg per week is not considered a therapeutic amount for reta, just as the usual starting dose of tirzepatide is not therapeutic either. Lower amounts mainly help the body adjust and reduce the chance of side effects. I believe reta is not expected to produce weight loss until around 4 mg weekly, so I would continue increasing slowly.

In the studies, 1 mg of reta weekly produced noticeable weight loss over a year. The reason for beginning low is the wide range of individual sensitivity. When I tried ozempic I could not go above 0.5 mg without bad nausea and had to split doses very finely. With tirzepatide I had almost no side effects at any level. Starting slow protects the small percentage of people who react strongly.

I began at 0.5 mg because I had been very sensitive to ozempic before. I felt nothing until I reached 2 mg, which is the usual starting amount in trials, and then hunger suppression appeared. Reta is fairly average at blocking appetite. Once levels build you should notice food noise becoming easier to manage. If you are looking for strong nausea or stomach effects then other compounds might be stronger, but trying to feel sick just to eat less is not a good long-term plan.

It really varies between people. Some trial groups began at 2 mg and you could do the same. I did not notice real appetite changes until 6 mg and most of the effect came at my current 8 mg. It is not known as a strong appetite suppressant, so give it time to accumulate.

The timing of this thread is helpful. I just took my first 0.5 mg dose today and, because I am used to other substances, it feels like nothing happened and I wonder if it is even working. I have also seen comments that reta is not very strong at appetite suppression, yet it seems to produce more weight loss overall. Why would that be?

From what I have seen, reta does not suppress appetite much until higher doses. If you need quick hunger control at a low dose then sema would be the better choice because it reduces food noise within a couple of days even at a small starting amount.

It takes patience because the benefits build gradually. In my case a mild reduction in hunger came first, followed by the sense that I did not want to keep eating. You may find yourself choosing smaller portions before you lose interest in food entirely.

Most people have already said it, but this is still a low dose and the first eight weeks are mainly about letting your system adjust. I have not used reta myself, but reports suggest tirzepatide usually gives stronger appetite control. If nothing changes after about two months you could consider adding cagri, which is known for stronger hunger reduction.

I could have predicted that the first thing visible in this thread would be someone mentioning 0.5 mg.

For me the real change with reta began once I reached 2–2.5 mg per week, although I noticed a small difference even at the starting 0.5 mg. Around the 2 mg mark it felt like a big shift: appetite dropped sharply and nothing sounded appealing. It was very effective.

I have only gone up to 1.5 mg per week and do not notice strong appetite suppression, but I also do not seem to mind being hungry. It becomes easier to skip snacks even when my stomach growls, and the scale continues to move downward slowly. I think it is useful to still feel hunger so you can build better habits for when you eventually stop or lower the dose.

I had never used any GLP-1 medication and started reta at 2 mg. I lost 8 lb the first month with no side effects and no noticeable change in how I felt. I stayed energetic, kept exercising, and made good food choices. Because it was a trial I had to increase every four weeks. At 4 mg appetite suppression began and at 6 mg it increased but fatigue also appeared, which was already too much for me. Everyone responds differently, so at 0.5 mg twice a week you still have room to test higher amounts and drop back if needed. Once you pass 2 mg weekly, give the current dose several weeks to reach steady levels before judging how it feels.

I did not split the dose and noticed nothing until 6 mg once a week, with stronger results at 8 mg. I had already used sema and tirz previously.

Everyone reacts differently. I began at 1 mg weekly like you and felt nothing. At 2 mg for three weeks I thought there might be a slight improvement in portion control. Now at 4 mg I know it is working because I have had no hunger since Friday’s dose, yet I can still eat if I decide to. A friend who tried the same product felt it right away at 1 mg with a big drop in both hunger and food intake.