MOTS-C Timing and Dosing for Endurance Sessions

MOTS-C should give a boost before workouts, though 200 mg caffeine does too. For endurance it is supposed to produce a measurable difference, for example a 3-4 % rise in average watts on a hard ride that would count as real rather than placebo. Who knows with all the different reports. KLOW is mainly for repair, skin, and inflammation, right? I bought some cheaply for a friend and saw posts about it. I plan to start low and watch for reactions; if anything big shows up I will probably drop it because I want to keep things simple.

Have you calculated your HOMA-IR to gauge mitochondrial function?

I have not yet. I will get insulin and glucose checked this week and report back. Right now I am going by how good I feel with diet, exercise, and sleep dialed in. I just started HGH ten days ago so I expect more changes from that. Hopefully the Tirz is helping offset any insulin-resistance increase.

HOMA-IR came back at 0.80, which is optimal. Just got the results today.

That's great since the energy centers inside cells probably won't gain much by adding MOTS-c.

Planning to pause MOTS-c for the next three months. Felt wiped out right after my midday meal lately and spent time ruling out everything else until I traced it back to that compound. It shows up once the system has enough and homocysteine begins climbing. Still plan to keep NAD+ on alternate days plus daily SS-31. Acting as the test subject sure isn't simple.

The HOMA-IR calculation does not assess how well mitochondria are working. It only uses fasting levels of blood sugar and insulin to gauge how resistant the body is to insulin. Problems with mitochondria might link to insulin resistance without turning that calculation into a direct indicator of mitochondrial status. Even though connections exist between them, one does not always lead to the other. Appreciate the post, found it intriguing. With my own HOMA-IR reading at 0.5, daily use of MOTS-c still seems helpful to me. In contrast, NAD+ often leaves me feeling drained, requiring caution in its use. My situation appears nearly reversed compared to yours.

When I looked into what occurs inside muscle and liver cells during energy overload, the power plants there normally consume fats plus sugars to make fuel. Yet once incoming calories especially from fats and processed sugars outpace actual needs the internal chain slows down and backs up. Partial fat breakdown then leaves behind harmful leftovers that include specific lipid forms. Those leftovers switch on enzymes which attach a phosphate to a signaling protein at the wrong position and this cuts off the insulin response. Blood sugar therefore stays high until extra insulin gets released which shows up on lab checks as elevated resistance markers. Since the core problem is overloaded cellular engines the markers drop when fuel intake falls through skipped meals or overall lower calories or when the engines are pushed to run faster via triggers that either create fresh ones or waste proton energy as warmth to clear the backlog.

I already acknowledged that problems with mitochondria might play a role in insulin resistance. That should have been obvious from what I wrote before. The key thing I'm trying to say is that this HOMA-IR calculation by itself doesn't assess how well mitochondria are working since it just uses fasting insulin and glucose levels. Just because the two are linked doesn't turn HOMA-IR into an indicator of mitochondrial condition. Studies in people demonstrate they don't always go together so someone might show normal HOMA-IR values yet still experience mitochondrial issues.

Yeah, I'm dealing with something comparable, although it looks like I benefited from a substantial placebo effect. This is a solid thread.