CommunityCompound Experiences

Anyone tried fasting on GLP1s?

38 replies24 peopleJul 2, 2026☆ Follow
Summary

How does fasting feel and work while taking GLP-1 medications like tirzepatide or retatrutide?

Most users find fasting easier on these drugs, with reduced hunger allowing longer windows or multi-day fasts without much struggle. Some report they now struggle to eat enough calories or protein and have stopped longer fasts, while others continue daily time-restricted eating or occasional extended fasts. Concerns raised include muscle loss, gallbladder issues, and possible differences between medications due to glucagon activity. People generally adapt their approach based on energy levels and bloodwork rather than following a fixed plan.

What this discussion establishesWhere people disagree

Whether retatrutide makes extended fasting unsafe because of glucagon-driven ketoacidosis risk versus the view that normal intermittent fasting remains harmless.

Still open

Long-term effects on gallbladder health, gut microbiome, and optimal fasting length while on these medications.

Nothing here is advice.

38 replies · 24 people
ClearKettle55archiveopening postJul 2

I used to fast years back and enjoyed the mental clarity it gave. Haven't done it in a while but I'm thinking of trying again this weekend. Has anyone fasted while on a GLP-1? The slower stomach emptying means you really need to watch how you break the fast so you don't overdo it.

CopperBeacon14archiveJul 2

Yes, it's much easier on these meds. I do at least 24-hour fasts two or three times a week and feel great. I can stretch to 48 hours or more when it seems useful. On non-fasting days I usually eat one meal a day.

PlainAnchor67archiveJul 2

I recently finished a three-day fast and felt okay throughout. I also do daily intermittent fasting, usually waiting 16 to 18 hours between meals.

AmberCinder18archiveJul 2

I fasted before starting the medication, but now I'm worried about it because I already have trouble eating enough to keep up with my activity. I've run out of energy mid-day before when I under-ate. It's strange that fasting used to be easy for me but feels different now.

GreyHarbour68archiveJul 2

I've been fasting for fifteen years by skipping food until noon and eating once or twice daily. The GLP meds make it even simpler, though I rarely feel real hunger anyway.

AmberCinder18archiveJul 2
↳ replying to @GreyHarbour68

By that standard I guess I qualify too. I eat breakfast and lunch early and then stop for the rest of the day.

NorthWillow72archiveJul 2
↳ replying to @ClearKettle55 (opening post)

I did intermittent fasting the whole time I was working toward my goal weight using an 8/16 schedule. The medication made the 8 pm to noon window easy. I still have coffee with cream after lunch and sometimes mix in a vanilla protein shake.

LevelAlder29archiveJul 2
↳ replying to @ClearKettle55 (opening post)

I haven't tried a full water fast yet on these meds, but I keep a four-to-six-hour eating window most days and it's fine. I've been doing intermittent fasting for about ten years mainly for schedule reasons. I actually think the meds help prevent overeating when you break a fast because you get full quickly after a few hundred calories.

SlowBramble67archiveJul 2

I've been doing it daily from 5 am until noon for the past three weeks. It really starts the night before, so basically 10 pm to noon.

WarmCompass44archiveJul 2

I used to do 24-to-48-hour fasts weekly for months, but once I started the GLP meds fasting became harder even though I fill up faster. I still need to eat at least twice a day. I suspect the glucagon is the reason.

QuietWillow76archiveJul 2

I kept fasting for over a year because it was the only way I could avoid gaining weight too quickly. After some time on maintenance I slowly added small morning items and didn't gain. I was very strict before the meds and wouldn't even have coffee with creamer during the fast. Now I eat when I'm hungry and add calories to my coffee most days. I still avoid big morning or lunch meals so I have room for dinner. On vacation I'll have one big breakfast but otherwise I don't stress about staying in ketosis.

WarmWillow50archiveJul 2

I end up fasting but not on purpose because the medication makes me have to remind myself to eat. With a history of bariatric surgery and malabsorption, fasting too long risks missing nutrients. It has become very easy to skip meals but it leaves me drained.

WarmAnchor46archiveJul 2

I fast every day for at least sixteen hours, usually around eighteen. I focus on protein and complex carbs because fitting everything into the eating window is tough otherwise. I've been doing intermittent fasting off and on since 2016, so combining it with the meds feels straightforward. Bloodwork is the real measure of whether it's working.

BrightCompass30archiveJul 2
↳ replying to @AmberCinder18

Which medication are you on? Retatrutide might be different because of the glucagon part if you're not already using it. I've done multi-day fasts before these meds but haven't tried since starting retatrutide.

WarmAlder92archiveJul 2

I did intermittent fasting and strict keto before the GLP-1s, but on tirzepatide I had to make myself eat so I wouldn't lose weight too fast. Losing more than two pounds a week or one percent of body weight is usually the edge of healthy loss. The one I would avoid fasting on is retatrutide because the glucagon effect could push the body into starvation mode or even ketoacidosis.

WarmAnchor46archiveJul 2

That's interesting. I'll update everyone if anything goes wrong. I don't think a daily intermittent fast with proper meals would cause problems. Back in 2016 people warned me intermittent fasting would kill me, but my bloodwork stayed excellent. Prolonged fasting might be different, but I'm not worried about the daily version.

GreyCinder78archiveJul 3
↳ replying to @WarmCompass44

I used to do rolling 48-hour fasts for a year. Looking back I don't think it was great for my gut microbiome. I did lose sixty pounds though. Fasting can help with loose skin that sometimes appears after these medications.

CopperBeacon24archiveJul 3
↳ replying to @ClearKettle55 (opening post)

Fasting worked well for me early on tirzepatide and helped drop the first chunk of weight with an 18/6 schedule. Just remember to watch muscle loss because it can happen quickly. I think fasting in cycles is useful, but then eating enough protein and training hard several days a week is important so you don't end up with sagging skin or face.

BlueHarbour89archiveJul 3

I'm currently doing intermittent fasting and some of the experiences shared here make me look forward to continuing.

WarmCompass44archiveJul 3
↳ replying to @GreyCinder78

I lost about twenty pounds while fasting but it was hard to build muscle because I was always short on protein. It's easier to hit my protein target now.

ClearKettle55archiveJul 3

Tomorrow I'm having an early dinner, then taking my weekly retatrutide dose Saturday morning and trying to fast until sometime Sunday. I might add a MOT-C dose and do a fasted gym session. This time I'm lowering caffeine to just one earl grey tea a day so it will be a pure water fast.

GreyCinder78archiveJul 3
↳ replying to @WarmCompass44

That's why I'm using the GLP-1 now too. Muscle loss was pretty bad when I was only fasting.

RustSparrow51archiveJul 3
↳ replying to @WarmCompass44

I was going to say the same. I was on keto and intermittent fasting long before these peptides and used to do 20/4 daily plus a three-to-five-day water fast once a month. Right now I'm off cycle for a couple weeks because of an upcoming procedure and find it easier to fast without the medications. Before stopping them I could barely manage my usual 20/4 window.

ClearSignal10archiveJul 4

I've done intermittent fasting on and off, eating from around noon to 7 pm. I'm about to start retatrutide and keep hearing I need lots of protein. I'm wondering if I should drop the fasting because fitting enough protein into those seven hours feels difficult while working.

ClearKettle55archiveJul 4
↳ replying to @ClearSignal10

I used a food tracker for the first week or so on retatrutide to see what nutrients I was missing. It might help you too. Retatrutide doesn't suppress hunger or eating capacity as much as semaglutide or tirzepatide, but the slower gastric emptying still makes big meals feel heavy.

ClearSignal10archiveJul 4
↳ replying to @ClearKettle55

I'll use a tracker again. When I microdosed semaglutide it didn't curb appetite much after a few days, so I was still fasting but struggled to hit protein goals. I think I'll need more shakes on retatrutide. I started today at 0.5 and may add another 0.5 later.

SlowCinder33archiveJul 4

I've never been much of a breakfast person so I've naturally done 16-to-18-hour fasts most of my life. I used to do 24-to-36-hour fasts a few times a week before tirzepatide. Since starting the medication I haven't managed a full 24-hour fast despite trying. I already have trouble getting enough calories so maybe it's for the best.

PatientBeacon15archiveJul 4

Fasting feels very natural on tirzepatide, though for me it's mainly the one-meal-a-day version. Before the medication I could already go from noon lunch to 1 pm the next day.

ClearKettle55archiveJul 4
↳ replying to @PatientBeacon15

How large is that meal? Does it make you feel overly full like the kid in Charlie and the Chocolate Factory? Eating a lot on retatrutide makes my stomach let me know right away that things aren't moving through quickly.

ClearSignal10archiveJul 4
↳ replying to @ClearKettle55

Once I'm further along on retatrutide I expect I'll need to pay attention to how my stomach handles food.

PatientBeacon15archiveJul 4
↳ replying to @ClearKettle55

On tirzepatide I would fast all day and eat dinner, but only about a third to half my usual portion before feeling full. I also didn't want dessert afterward. I did feel bloated sometimes.

ClearKettle55archiveJul 5

I finished a 35-hour fast. Woke up, took MOT-C, walked the dog for 1.5 hours, did a light 1.5-hour gym session with stretching, sat in the sauna for 19 minutes, then went to an icy river with friends for a few dips. Went to bed, did more MOT-C in the morning along with glycine, NAC, psyllium, and electrolytes, then jogged 5 km with the dogs. Feeling good and hoping to make this a monthly practice.

IronHarbour22archiveJul 5

The day after my retatrutide shot is usually a good day for fasting. I don't do it every week but it's easy when I choose to. Typically a small early lunch then a 24-hour fast until the next day's early lunch. It's pretty straightforward on retatrutide and helps adjust weekly calories.

RustSparrow51archiveJul 7

I just finished a 112-hour water fast for an upcoming procedure. First refeed was bone broth, then baked avocado sushi-style, then half of a 3x3 Flying Dutchman. I'll restart retatrutide at a low dose on Wednesday.

ClearKettle55archiveJul 7
↳ replying to @RustSparrow51

Nice! Had you done fasts before retatrutide or other GLP-1s?

RustSparrow51archiveJul 7
↳ replying to @ClearKettle55

Thanks. Yes, before retatrutide I was on keto and intermittent fasting and usually did a three-to-five-day water fast once a month. That approach dropped about thirty pounds over two-plus years, but retatrutide helped me lose another twenty in six months, so I'm staying on it.

BrightCinder35archiveJul 29

I read that fasting on GLP-1 meds might raise gallbladder problems. Does anyone know more about that?

KeenKettle50archiveJul 29
↳ replying to @BrightCinder35

Maybe drink a lot more liquid? The body still produces waste whether you're fasting or not.

BrightCinder35archiveJul 29
↳ replying to @KeenKettle50

The risk goes up because GLP-1 meds and skipped meals reduce how often the gallbladder contracts, so bile sits longer. Rapid weight loss also adds extra cholesterol to the bile. Long periods without food mean no dietary fat to trigger gallbladder release.

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