Appetite Suppression Ranking of the GLPs?

Tirzepatide since early March gets a 7 from me. I still eat daily but no longer feel constant hunger.

How can anyone assign a single number when they have only tried one of the three?

Only retatrutide so far, now at 5 mg, and I notice almost no hunger reduction, so 2 on that scale. Started at the beginning of the year and will try 6 mg next week; if that still does nothing after six months I will stop. The batch tested overfilled with high purity, so it's not fake product. Planning to try cagrilintide or eloralintide later once prices drop.

GLP ranking: semaglutide first, then tirzepatide, then retatrutide. GIP ranking: retatrutide first, then tirzepatide. Cagrilintide response varies; at 0.5 mg it crushed my appetite. It works on amylin receptors, not GLP.

My normal hunger would already be minus 100; retatrutide brought it to zero. Yes, the product is real. The most powerful option should work dramatically, so maybe some people are just unlucky.

Tried all three. Tirzepatide gave the strongest appetite drop. Semaglutide and retatrutide felt about equal.

Response seems very personal. Semaglutide for nearly a year did almost nothing for me. Retatrutide works well and fully removes hunger, a 10. I can still eat when needed. Planning to lower the dose soon and expect hunger to return, so I have cagrilintide ready for maintenance.

Only retatrutide experience. Hunger control is still present and I fill up quickly. The last week and a half the side effects have disappeared, including heartburn, and sleep has improved.

Does any of this ranking actually matter?

Tirzepatide since early February, still at 2.5 mg, has removed all hunger signals. I had to track calories to avoid undereating. Inflammatory markers have not improved and even rose slightly. A fibromyalgia flare in April stopped weight loss. Added 1 mg retatrutide last week hoping it would restart loss without extra appetite drop, and it did. Now down two pounds with similar suppression. So tirzepatide is 10, retatrutide 1 for me, yet retatrutide restarted progress on the scale.

Only retatrutide at a low dose so far, wanting the fat-burning effect without losing all enjoyment of food. It has reduced snacking outside meals but overall appetite change is modest, though weight is dropping. Ordered tirzepatide as backup and also curious about tesamorelin for muscle while cutting. Main interest was effects on blood markers and inflammation; cholesterol and fatty liver flags make the next labs important.

Tried semaglutide and tirzepatide. Semaglutide scored 10 but partly because I felt sick constantly. Tirzepatide is 7 and I like it more. No retatrutide yet.

No semaglutide experience. Tirzepatide 8, retatrutide 6.5, cagrilintide 9. Both tirzepatide and cagrilintide suppress too strongly for me. Retatrutide strikes the right balance of still being able to eat while controlling cravings.

Good question because the three compounds reduce appetite differently even when scale results look similar. Personal scores: semaglutide 6, steady background effect where food thoughts decrease but cravings remain. Tirzepatide 8, much stronger satiety from the GIP part; half a plate fills you and more food feels off-putting. Retatrutide 5, milder than both despite being triple agonist. The interesting part is why retatrutide still drives loss when hunger control is the weakest of the three.

Ten weeks on retatrutide up to 4 mg. Slight effect started at 2 mg but became noticeable only at 4 mg. It doesn't strongly suppress appetite; instead it creates a mild full feeling and faster satiety.

Tirzepatide can raise thermogenesis via GIP-driven futile calcium cycling, though far less than retatrutide's glucagon effect. Retatrutide also performs some calcium cycling.

Retatrutide has actually given me better appetite control than the other GLPs once the dose was right, helping maintain the deficit.

Shows how individual results are. Retatrutide let me skip food entirely, making protein intake difficult and requiring shakes. Lost interest in sugar and preferred simple meals. Would rate it 9. Now on tirzepatide and find it frustrating; nausea is not the same as appetite control even if the outcome is similar. Electrolytes help a bit. The worst part is sometimes it allows the wrong food then punishes with stomach issues. Fine for maintenance but only a 3 if nausea is ignored.

Sticking with retatrutide so far but plan to switch to tirzepatide for maintenance because of stronger expected appetite control and because tirzepatide keeps heart rate higher, which may not be needed once maintaining. Once retatrutide trials finish, longer-term medical guidance will probably reflect that.

At church so can't read everything yet, but my ranking is tirzepatide or retatrutide first (used together so hard to separate), then cagrilintide at 0.5 mg which hit hard. Other options include tesofensine, semaglutide, mazdutide, orforglipron, survodutide, eloralintide and more.

Started on prescribed semaglutide. First two months at 0.25 and 0.5 did nothing; effect began at 1 mg where I remain. Now stack with roughly 4 mg retatrutide split across the week plus 1 mg semaglutide mid-week. Hard to separate but semaglutide seems to add more appetite control. Retatrutide works differently. I don't want zero interest in food or nausea at the thought of eating, just removal of food noise, which the stack achieves. Also protecting muscle by prioritizing protein so I need to be able to eat. Sweet tooth is reduced; one sweet item satisfies without wanting more. Both rate 10 for me. Haven't tried tirzepatide though considered switching.

Semaglutide 7, responded fast at low dose. Tirzepatide 8. Retatrutide 5. Cagrilintide 2 with little personal benefit. Everyone responds differently due to pharmacogenetics and receptor factors.

Semaglutide 9.5, tirzepatide 8.5, retatrutide 6.