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GLPs and endurance cardio?

14 replies9 peopleOct 22, 2026☆ Follow
Summary

How do GLP medications affect endurance cardio and training capacity?

Users report noticeable drops in stamina and energy during long efforts like runs, rides, and hockey after starting low-dose tirzepatide or retatrutide. Fatigue appears tied to lower carb intake and slower digestion, with some relief from strategic carb timing, electrolytes, or added compounds. A few note no lasting change or even better fat-fueled endurance once adapted, while others cut volume or switch to easier efforts until weight stabilizes.

What this discussion establishesWhere people disagree

Some experience clear cuts in duration and power while others report unchanged or improved fat-based endurance with no drop after the first weeks

Still open

Whether mitochondrial peptides provide reliable benefits separate from the GLP itself or how long any endurance changes persist at maintenance doses

Nothing here is advice.

14 replies · 9 people
WryFenwick91archiveopening post13h

Curious if others here do longer cardio sessions, not just races. I finished a long bike ride a couple months back and began a low dose of tirzepatide three weeks ago. Even at this level my hunger is down and I feel drained for activity. Trying to add more potatoes, beans, and bananas but still hit a wall after twenty minutes running today. Has this hit anyone else and what helped?

RustTimber42archive12h

I push through by dragging myself to the gym even when I fade after forty-five minutes, down from ninety before. Strength stays the same but I get shaky sooner, especially training fasted. Endurance feels cut by nearly half. I try to load extra carbs into the evening meal around five or six.

WryFenwick91archive11h
↳ replying to @RustTimber42

Strategic carbs seem key. My partner, not on these meds, had a stronger ride last weekend while I used to manage two-hour rides without issue. Same with weights, so I shortened sessions and added shorter ones to see if that balances things.

IronQuill66archive11h

I play league hockey and notice muscles feel weak and tired rather than winded. On game days I eat more and sip small sports drinks, including one on the bench, which makes a noticeable difference though not back to prior levels.

PlainAnchor66archive10h

I do long climbs and century rides. While pushing hard on one medication I stopped chasing power numbers, rode for enjoyment, and switched to an e-bike for a few months. After reaching goal weight I moved to low-dose tirzepatide for maintenance and tried a couple peptides. One raised my functional threshold noticeably. Nutrition on the bike needs more planning because digestion slows.

WryFenwick91archive9h
↳ replying to @PlainAnchor66

I have heard positive notes on one of those peptides and may try it later, but weight loss is the priority now since the GLP route is simpler to access. I looked up the other one quickly and it sounds interesting. Did you test them one at a time to compare effects?

WryFenwick91archive9h
↳ replying to @IronQuill66

I should pick up sugar-free sports drinks. I used to like a certain electrolyte tablet brand but it costs more to get here now.

From what I feel, the low-energy state comes from missing carbs and the peptide seems to tap fat stores instead, giving a different kind of reserve that lets me go beyond usual limits. It feels like an extra tank rather than the usual glucose crash. This is just my own sense of it.

WryFenwick91archive8h
↳ replying to @NorthThistle23

You are the second one here mentioning that peptide. I wanted to stick with just the tirzepatide while focused on weight loss, but maybe it is worth considering.

PlainAnchor66archive8h
↳ replying to @WryFenwick91

Dosing schedules vary and sources conflict. At fifty-eight I noticed mitochondrial support helped me, but younger users might not feel it. I inject before workouts several times a week. Tried the other peptide alongside for two weeks and was not impressed enough to repeat. I prioritized fat loss first with the stronger medication and added the peptide later out of curiosity. One odd note is that the peptide is banned in sports while the GLP is not.

AmberMeadow80archive8h
↳ replying to @PlainAnchor66

How does the switch from the stronger medication to tirzepatide feel for training once at maintenance? Any clear differences in energy or recovery? The peptide data is useful, thanks. I am testing the same pair and curious how others are responding.

GreyAlder96archive7h

After the first few weeks any tiredness passed and my mountain bike rides in the ninety-minute range feel the same or slightly better. I make sure to add carbs before and during rides. It may just be the common startup dip or not eating enough for the effort.

SlowLedger99archive7h
↳ replying to @WryFenwick91 (opening post)

Dropping from long rides to struggling with short runs sounds tough. Hopefully the carb adjustments get your legs moving again.

PlainAnchor66archive7h
↳ replying to @AmberMeadow80

Resting heart rate is lower and sleep improved on the maintenance dose. Hard to separate other effects because the earlier phase was a steep deficit that limited hard efforts. Now with calories steadier I can hold longer work. The comparison is uneven due to the calorie difference. I accepted lower volume for a while and rode easy or used the e-bike with friends.

WryCompass65archive3h

Fifty-four, on the stronger medication, and track endurance metrics. Peak oxygen uptake hit fifty-four this summer before a recovery period. I felt strong on the mountain bike and wonder if the medication helped access fat stores for fuel. Could be individual or coincidence. Either way, solid nutrition and enough total calories seem necessary to keep energy available.

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