AMA on resistant starch fibers Akkermansia peptides and allulose dosing

All right, how would someone actually go about that?

Medically it might require antibiotics. Years ago while working long hours and eating poorly with lots of carbs I gained weight and had terrible smelling gas and stools. At a detox spa I did a 17-day fast with twice-daily colonics, only broth, coconut water, herbal supplements, and water. Day four was the lowest point, but by day five I felt better and toward the end I passed unusual material that was not normal feces. Hunger faded quickly and I stayed calm and reflective despite the process.

I am not sure exactly. I have not seen the procedure myself, but case studies mention doctors taking a sample from a healthy donor and placing it into someone with IBS, though I do not recall the precise steps.

Bananas contain polyphenol oxidase that breaks down flavanols from berries or apples before absorption, so mixing them in smoothies with other fruits is not ideal.

The oxidase does not destroy polyphenols outright; it oxidizes and polymerizes them into larger melanoidins that can still act as antioxidants. Green bananas are heat-treated so the enzyme should have little activity left. Even if active, stomach acid would likely affect polyphenols more than the oxidase, which denatures anyway.

Short answer yes. Longer answer: how you feel is not a strong guide to health because it is subjective and misses early colorectal cancer signs or weakening gut tight junctions that let waste leak back into blood. The descending colon is where colorectal cancer often appears, and proteolytic fermentation contributes through branched fatty acids, urea, sulfur oxides, hydrogen sulfides, and other uremic toxins.

I bought the greenest bananas available at the store. Am I on the right track? I have taken antibiotics recently and want to rebuild my biome, plus I have been eating yogurt, kimchee, and sauerkraut. Any other ideas?

Kombucha or kefir could work if you enjoy them, though I am not a food scientist so do not treat this as expert advice.

I have dealt with a sensitive stomach and lifelong constipation and other issues. Sunfiber has been the best fiber I have tried for constipation and related problems. I use the Tomorrow's Nutrition blue label version. The green one includes extra pre and probiotics that I prefer to add on my own.

Not really. Raw banana does not mash easily, but you can experiment if you want. Disclaimer that I am not responsible for any blender damage. I would suggest kefir because it contains more diverse lactic acid bacteria and yeast.

Galactomannan works well.

Picture icky water full of opportunistic bacteria, ammonia, uremic toxins, and pro-inflammatory waste like branched fatty acids entering the bloodstream. Yes, evidence is growing. Which fiber you pick depends on whether your goal is general health or a specific problem.

Good that it was caught early.

Leaky gut is recognized in research but not often used as a firm clinical diagnosis with proven treatments. Doctors rarely diagnose it because consistent tests and effective therapies are lacking. It is more likely with ongoing gut conditions such as IBD or IBS with diarrhea. Hundreds of small studies on pro, pre, and postbiotics exist but fall short of strong evidence, and the same applies to fiber supplements. A generally healthy diet such as Mediterranean style with mostly plants, moderate overall intake, and varied fibers or resistant starches is usually advised, though individual responses vary and some fibers can cause pain or bloating.

Hope you are doing okay now.

Wow, I did not realize we knew each other.

Thanks to both of you. Recovery signs look good, though I am still adjusting to a new normal. This community has been useful; without it I would not have considered a GLP-1 or peptides for faster recovery or learned about green banana flour.

Raw bananas are tough to blend smoothly, but try if you like. Disclaimer that I am not responsible for any blender issues.

Are we allowed to request recipes? I already make my own keto bread but would like to improve it.

Some studies on women's health and the gut exist, but that area was not something my company pursued despite my suggestions. I would add an apple.

If you are not gluten intolerant then sure. I am still working on a version that starts with resistant starch type 4, a phosphate-modified wheat starch that is 98 percent indigestible fiber and performs decently in cookies and cakes, though extra gluten needs to be added to mimic real bread texture.

How large a serving of that ingredient do you figure is needed before it starts helping? I picture folks mixing it into a protein shake or something similar so it never gets heated.

How exactly do polyphenols get absorbed?

A tablespoon, roughly eight grams, works well stirred into a fruit smoothie.

They can be taken up in the small intestine and then processed by the liver into phase-two metabolites, or they can reach the colon where gut bacteria convert them into other polyphenol forms that are later absorbed through the villi.

What exactly are you hoping to accomplish? Allulose does not count as fiber.

Either your resting metabolic rate is lower or she moves around more than it seems. Have you checked thyroid function? Gut health matters, but the field is still new and it is hard to tie any single bacterial shortfall to a particular metabolic problem.

Allulose is pretty interesting as a sugar replacement, though it is definitely not fiber. After reading papers linking erythritol to higher stroke risk and blood-brain-barrier issues, I looked for something else because almost everything on the shelf contains erythritol. Allulose does not raise blood sugar and rodent studies show it can reduce weight even at modest amounts, though human weight data are missing. I have not seen any studies flagging safety problems. Once an additive is labeled generally recognized as safe it is hard to remove even with suggestive evidence against it. So the most common bulk sweetener may carry questionable safety while allulose looks cleaner so far.

For a moment I thought you were just trying to set the world on fire by suggesting green bananas, but after reading the whole thread it makes sense.

Not the original poster, but anyone who has spent time in a bookstore knows plenty of gut motility issues start in the head.

Sorry for the mix-up. I was really asking about FOS fiber and gut health, not the sweetener itself. Is it worth the cost? I was going to stick with psyllium but it seems to block absorption of several of my medications.

A colleague looked into it. The organism has drawn attention because of its strong inverse link with obesity.

Anaerobic organisms like Akkermansia are tough to grow and even harder to turn into stable probiotics because oxygen kills them quickly. That probably explains why live cultures had to be imported. A handful of clinical studies show apple pectin and green banana can raise Akkermansia levels, though those trials were not focused on weight outcomes or washout phases.

Have you looked into oral forms of KPV or BPC-157 for gut problems?

I do not have any personal experience with them. BPC-157 looks promising because it influences zonulin and claudin, key tight-junction proteins in the gut lining.

I am no specialist, but BPC-157 is known for healing and KPV for calming inflammation. Plenty of people here report good results with these peptides when injected. I have read that both survive stomach acid and digestion reasonably well. If I faced the same issues you do I would give them a try. Tomorrow at work I can dig up an article I found and share it.

I checked the studies, especially on KPV, where animal work shows reduced colitis. Most sources indicate little if any of the peptide reaches the large intestine intact, which is why current research tries to attach it to other molecules so it survives longer or reaches the colon. The peptide itself may work, but delivery in sufficient amounts is the hurdle. Doses would probably need to be large compared with what is sold. Injection might be more effective, yet peptides usually have very short blood half-lives. No human data exist yet, and rat-to-human scaling does not guarantee the same colonic delivery because of longer transit distance. Akkermansia remains interesting; there are many papers on it.