Recreational substances and retatrutide

Bringing up schedule I substances looks like a fast route to getting the thread removed.

Curious how this might change things for people who rely on prescription pain meds for ongoing pain. Anyone seen any personal reports?

Thanks for putting this up. I stay away from those substances but the details are still helpful. I do drink and I am trying to stop.

Either direction looks risky. The safest move is to skip the topic.

This is interesting. Maybe replace certain words with emojis to stay safe?

The ban threat was mostly a joke. No one meant any harm so I doubt you would actually be removed. Still, I expect the thread will disappear. Peptides already draw enough negative coverage without adding schedule I talk.

My festival days are behind me but the details are still useful. Ketamine sees plenty of medical and psychiatric use so from a clinical view this helps medical staff. Thanks for testing and posting. Even if the thread gets taken down I will add that a well-educated friend who runs spiritual retreats with a traditional Peruvian substance starting with Ay. says GLP-1s are not ruled out but the shot should be timed well away from the event, roughly six or seven days. She did not address how the substance itself might change for GLP-1 users. Tirzepatide does not seem to alter cannabis when smoked, vaped or drunk, but edibles hit much later because digestion slows down. The effect still arrives, just out of sync with everyone else.

Mushrooms work normally unless taken the same day as the retatrutide shot.

Since it would be unrealistic to act as if these topics never come up and laws differ worldwide, the thread can stay for now. I have made some edits and expect everyone to act responsibly.

Thanks for testing and reporting. This makes me reconsider scheduling events involving mind-altering substances while on reta. I already suspected dopamine-related compounds would be affected. I have a couple of events coming up and will try to keep the GLP-1 dose as far away as possible. Losing weight has let me dance longer while staying completely sober, which I enjoy.

My usual mushroom amount stopped working once I started tirzepatide. I have to take quite a bit more to reach the same level.

I do not support using any of those substances and it seems counterproductive while optimizing health with peptides, yet these reports remain interesting. The retatrutide anecdotes keep surprising me.

Steer clear of tesofensine with any of those substances because it dulls the experience even more.

I take prescribed dexamfetamine. Before ozempic two years ago I could clearly feel when a dose kicked in. Once I started ozempic that sensation vanished. The drug may still have worked somewhat but the effect felt reduced and I lost the ability to tell when it was active. Slowed absorption might play a role but changes in dopamine signaling seem more likely. It is frustrating because the medication was more useful before.

Glad you posted. Two of the substances matched experiences I have had and I have not tried the rest.

This is useful information. Whether or not someone uses them, these substances are more common than some realize. Sharing personal results helps others who do use them. My own days with them are long over because my mental health cannot handle the downsides anymore. If I had not felt the usual effects while on GLP-1s I would probably have taken more trying to recapture the old feeling. It also raises the question of whether reta could help people dealing with addiction to these substances. I switched back to tirzepatide recently but my prescribed ADHD medication did not seem affected by retatrutide.

That is a handy set of observations. I am heading on holiday in two days so now I know not to spend money on cocaine. Thanks, you saved me some cash.

Good idea to talk about these interactions. I have been wondering whether my migraine medication has become less effective lately and I am also on reta.