ForumResults & Progress

Reta just kicked in

9 replies5 peopleOct 27, 2025☆ Follow
Summary

What non-weight-loss effects does retatrutide have on appetite, reward pathways, and metabolic symptoms?

Users report a rapid drop in appetite and food reward after low doses, along with reduced interest in alcohol and other habits. Several note similar shifts in desire for sweets, rich foods, or intimacy while still functioning normally. People with prior insulin resistance or lipid issues describe metabolic improvements and easier calorie reduction without hunger. Concerns surface about rebound if habits are not maintained and about whether the ease feels like cheating.

What this discussion establishesWhere people disagree

Whether the rapid results constitute cheating compared with prior disciplined efforts, and whether rebound risk is mainly a matter of personal habits.

Still open

Long-term durability of metabolic improvements once dosing stops and whether reduced drive for intimacy resolves or persists.

Nothing here is advice.

9 replies · 5 people
SharpHarbour71archiveopening postOct 27, 2025

Wanted to track my experience with retatrutide, mainly for metabolic healing rather than weight loss. I'm 6'3" and 197 lb but would like to drop about 15 lb. I show signs of insulin resistance and metabolic slowdown. After reading a new book that lays out a strong case for these peptides, I started at 0.5 mg every four days. Third shot was yesterday. Today the effects appeared: almost no appetite, had to push myself to eat, food no longer feels rewarding, more eat-to-live than live-to-eat. Also lost interest in alcohol and cannabis the last few days.

KeenLantern39archiveOct 27, 2025

The dopamine and reward-system reset is a great effect. For that reason alone they are worth using.

SlowHarbour85archiveOct 27, 2025
↳ replying to @SharpHarbour71 (opening post)

Good to see more people using these for health gains beyond weight loss. The reward shift has been strong for me too. I went from not really wanting sweets or fast food to feeling nauseous at the idea of junk, especially rich items like chocolate or pastries. It can also lower interest in intimacy; everything still works but there is no drive and it does not bother you. I saw online that it is a known side effect. Why do you want to lose weight? My husband is the same height at 195 and stays lean with visible abs. Seems like a solid weight, but maybe it is about body composition?

SharpHarbour71archiveOct 27, 2025
↳ replying to @SlowHarbour85

Thanks for the feedback, interesting stories. I probably do not carry nearly as much muscle as your husband if he is defined at 6'3" and 195. I play a lot of tennis and extra weight hurts movement, so I want to reach the low 180s to get back into playing shape. I have put on a little fat and it is affecting my game.

SharpHarbour71archiveNov 11, 2025

This has to be cheating. For years I worked hard to cut fat and build muscle for athletic reasons, some vanity too. It was always difficult and took steady discipline, but I could reach my goals. Now that I am older it is much harder. Retatrutide feels like an easy hack. I think I am eating the same as before, yet my logs show about 25 percent fewer calories per week. Still no hunger, do not think about food, feel full. Consistently losing 1 lb a week on 1 mg every four days. Crazy in a good way.

CopperCompass90archiveNov 12, 2025
↳ replying to @SharpHarbour71

Funny how nobody calls taking medicine for other conditions cheating. A GLP can treat obesity, the second-biggest killer in the US after cancer and a cause of many cancers. A weekly shot that prevented cancer would not be viewed as cheating, except perhaps by Christian Scientists or some Amish.

KeenLantern39archiveNov 12, 2025
↳ replying to @SharpHarbour71

The catch is that if you do not build healthy habits you can rebound when you stop, and repeated weight swings might harm body composition over time and lead to other unknown problems.

AmberMarble84archiveNov 12, 2025

These are impressive drugs. I am perimenopausal, became insulin resistant after pregnancy six years ago, developed high lipids, and started gaining weight. I want to lose the weight but care even more about metabolic health. Being thin alone will not keep the body healthy. I feel lucky. Sema did nothing for me, but tirz and now reta are working well. I also take a little metformin because it is a solid drug, though I probably do not need it anymore.

SharpHarbour71archiveNov 13, 2025
↳ replying to @KeenLantern39

Agreed, but for me it is not a big worry. I have kept clean eating and lifestyle habits tight for about twenty years. Still, I have signs of metabolic trouble: borderline high blood pressure, lipids out of range, fasting glucose and A1C creeping up. Hoping reta can deliver a metabolic reboot.

SlowHarbour85archiveNov 15, 2025
↳ replying to @SharpHarbour71

Yes, especially for a sport like tennis. I have four daughters in tennis, gymnastics, swimming, and cross country, and we are starting to talk about how food affects performance. Trying to handle the body-composition talk without triggering disordered eating. Have you tried creatine? A lot of athletic researchers swear by it. I noticed more tiredness and am not sure why, though most people seem to like it. Good luck getting lean, 15/love.

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