The unfortunate end to my Reta journey.

The Reta passed testing. I tried two different sources and got the same reaction both times. Went as high as 8 mg then dropped to 4 mg for maintenance. Allodynia was bad at the higher amounts but cleared once I lowered it. The rash didn't start near the injection spot. It began on my legs and arms, moved to my neck, and now covers most places except my back and stomach where I inject. I've had to take several rounds of antibiotics because the itching gets so bad the skin becomes infected. Can't keep dealing with it so switching makes sense.

That lines up with what has been reported in testing about Reta and skin problems. Impressive you stuck it out through everything. Any improvement in the skin after stopping a couple weeks ago? I'm a big supporter of Tirz. Good luck and keep us posted on how it goes.

It's interesting you keep seeing a steady drop even after lowering the dose. My own loss has flattened into a gentle curve down to goal and now basically stopped even though I stayed on the same amounts the whole time. Actually added sema on top and it's still a mystery.

I feel a bit odd for pushing through it that long. The itching has eased quite a bit and no new spots are appearing. Never had this issue on Sema or Cagri so I'm hoping Tirz will be similar. Also lost a lot of hair on Reta that the others didn't cause, and Minoxidil isn't helping, so maybe Tirz can sort that out too. Most of the weight came off on Sema but I stalled and switched to Reta hoping for more progress. Thought lowering the dose would help but it got worse instead, so Reta just doesn't suit me. I'll update once I'm settled on Tirz and the Reta has left my system.

Hoping 2.5 mg will be enough to hold my weight.

Thanks.

Tirz is what I mainly use for maintenance too. I only bring Reta back in if the scale starts creeping up. Sorry the rash ended it for her, that sounds rough.

I'm 13 pounds from my second goal. Eating and exercise haven't changed. The compounds are the same but the scale has slowed down. Went six days with no movement, something I hadn't seen before. Not changing anything, just adjusting what I expect. Once at goal I'll keep the levels steady until something clearly needs tweaking.

Yeah the scale can drop suddenly. Maybe by Friday I'll be back to my usual weight unless I'm actually losing the belly and love handle fat. Those side handles are definitely getting smaller. I've taken over this thread enough.

I believe it was the orange T30.

It was Reta not Tirz and I bought from two different places with the same outcome. Guess my skin just doesn't tolerate Reta well.

In what way do you see Reta as hard on the system? My body responds well to it. It improved every blood marker, resting heart rate, blood pressure, A1C and so on.

I had pretty much the same experience with Reta. Side effects stayed low and the benefits were great. Like many others my labs moved from mostly red flags in metabolic areas to mostly good readings. Cholesterol stayed above 200 though.

That's correct and I had the green capped version at the time. Yes I know you were on Reta, I just meant contamination can occur, but I didn't realize you had tried different sources. That really is unfortunate. Tirz it is then. Just watch out for older orange capped Tirz on sale. I think dropping the extra weight from the last couple decades is the biggest win. Has Reta changed your resting heart rate at all? It affected mine for a while but after a year it's back in the 70s. Started a statin recently. There's a gene-editing trial going on you might look into. They give one injection and it alters the cholesterol pathway for a year.

Hope it works out for you.

My resting heart rate actually dropped on Reta. I had a high rate before and I'm not exaggerating when I say Reta fixed everything. Of course the weight loss helped but after six weeks my bloodwork did a complete turnaround and my doctor was surprised, saying he'd never seen numbers improve that fast.

A recent study backs that up and I can confirm it. I used to sit around 72, went up to the 80s, then after 41 weeks settled back to 70-72. Retatrutide side effects from the trials include nausea in 43 percent, heart rate up about 6.7 bpm, and dysesthesia in 20.9 percent at the 12 mg dose. Not approved in the UK yet. The phase 2 trial showed a dose-related rise in resting heart rate. At 12 mg it averaged around 6.7 beats per minute, peaking near week 24 and easing back toward baseline by weeks 36 to 48. The glucagon component is likely why, since it raises resting energy use which tends to increase heart rate. That increase is higher than what's seen with Mounjaro or Wegovy.

I got Tirz from a source that should be fine though it costs more. My resting heart rate barely moved on Reta, stayed in the high 50s to low 60s. The rash is the only thing that caused real problems.

I'd hate for that to happen after stocking up. I guess that's one of the risks though.