Maintenance approaches after reaching goal weight on Reta or Tirz

Why choose 5mg Tirz specifically for the maintenance phase?

I'll be in a similar spot once I drop another five pounds. Need to begin exercising to lose the last stubborn belly fat. Also have some dumbbells sitting around that I should start using.

Maintenance since May 2025. Did not do any washout and stopped Tirz abruptly after using it for almost exactly one year. Maxed at 15mg for five months. Most loss happened earlier when moving from 12.5 to 15mg. Last twenty pounds came at the 15mg dose. In the final two weeks tapered to 10mg and added 0.125 Cagri, then dropped Tirz completely the next week and started 1mg Reta with 0.25 Cagri. Stopped Cagri by November 2025. Ended up losing another fifteen pounds unintentionally on the Reta/Cagri stack so discontinued that. Now stable on 3mg Reta once weekly. Weight holding and able to eat normally again.

Sounds like a reasonable plan. Tirz tends to be gentler than Reta. Noticed energy dipped a bit at 4.5mg Tirz even though that dose controlled appetite well. Lowered to 3.5mg and added 1mg Reta on the same day each week. Energy returned to normal while appetite control stayed the same. Resting heart rate did not change which mattered to me.

The RHR increase with Reta worries me. Nice cat picture though.

Three pounds from a 110-pound goal but might aim for 105 instead. Never went above 5mg Tirz. Looking into Cagri for appetite control so I can taper off Tirz and see if it holds the suppression. The idea of food noise returning is frightening. Has anyone used Cagri alone just for that without any GLP-1?

Saw a video explaining how the glucagon action in Reta depletes glycogen in the kidneys. That works short term but animal data suggested possible kidney problems with prolonged depletion. Planning to switch to Tirz once I reach maintenance. Had not heard of Cagri until this thread and it sounds worth checking out.

From what I am reading here it seems nobody ever fully stops Reta or Tirz without replacing it with something else?

Shared a video on the topic.

Still too far off for me to think about.

Close to goal myself. Once there I will focus on toning, probably eat a bit more, and keep the current 3mg twice-weekly dose. Planning to add Tesa/Ipa for a cycle to see the results. When my current supply runs out next year I may switch to Tirz because it seems to control appetite better. Will just decide as things go. If Tirz suited you better then going back makes sense.

Why switch away? Just hit goal on Reta plus Cagri and facing the same question. Most of my loss came from Tirz alone so returning is possible, yet stopping the glucagon effect feels like a loss. Current schedule is 7mg Reta every three and a half days plus 1.7mg Cagri weekly. Easiest continuation might be dropping Reta to once weekly and adding another weekly compound three days later. Options include pairing with Tirz, Eloralintide, or Cagri again, or simply using 15mg Tirz weekly from the pens I have stocked.

Also trying to map out an exit plan. About five pounds from goal and already on fairly low amounts compared to others: 5mg Tirz Mondays and 1mg Reta Thursdays. Planning to test Cagri soon to see if it fits. Know myself well enough that stopping suddenly would not work out well.

There is no direct conversion. To add fifteen pounds of muscle you need to shift into a calorie surplus for a while, train hard, then cut the extra fat afterward.

44-year-old male, down sixty pounds. Four weeks into maintenance at 1mg Reta every five days. Feeling decent so far.

You did not say how much weight was lost, which matters. With major obesity, low-dose maintenance can be tried but the original effective dose is usually needed long term for health reasons. With less severe starting weight the same logic applies. Evidence points to staying at the dose that produced the loss, though many here succeed with reductions. Maintenance is the hardest part but most important for health.

These meds treat the actual drivers of obesity such as constant hunger, food fixation, sugar cravings, and emotional eating. The gap between people who stay slim without effort and those who fight urges constantly is physical or neurological, not just willpower. Stopping the medication brings back the original problem. Anyone who struggled lifelong and now succeeds thanks to these drugs should probably continue because their system requires it. No shame in using a tool when there is a real deficit, similar to taking insulin for diabetes.

Haha, mine is the Michelin Man.

At goal weight and unsure what comes next. Skipped the shot last week and felt ravenous, so that is not an option. Probably will stay on these meds for life. Might try lowering the dose or switching to Tirz but I like how Reta feels so may keep it. Been obese for years and will not suddenly maintain naturally. Maybe in a few years the brain's set point will adjust, but time will tell.

At goal for a year now holding with 8mg Tirz weekly split into two doses. Some weeks add a tiny 0.13mg Sema if cravings creep up. Other weeks drop to 2.5-3mg Tirz when I want to eat more freely.

Stopping after goal weight is reached is not wise because these drugs offer longevity and metabolic advantages beyond appetite control. They improve insulin sensitivity, raise resting calorie burn, and support overall metabolic health. A low maintenance dose prevents rebound while good habits formed during loss continue to help. Extra benefits include reduced mental focus on food. Staying on has more upsides than quitting.