Began testing with nicotine patches at seven milligrams over the first seven days. I figured on a modest uptick in metabolism, some rise in blood pressure, and maybe clearer thinking. Never developed a smoking routine myself, though I dabbled briefly as a teen without getting hooked.
Raised the reta amount to three milligrams at the start of the month and aim to stay at three milligrams twice weekly until hitting just under two hundred pounds. Felt a faint skin itch for the first time, yet it faded within roughly half a day.
Eating habits are mostly back in line, probably landing between seventeen hundred and two thousand calories without exact tracking. Cutting back on sugars while falling short on fluids this week.
Stats showed average blood pressure at one seventeen over seventy two, lower than anticipated, resting heart rate of sixty eight, HRV twenty eight percent, sleep score sixty six, deep sleep twenty seven percent, and stress at thirty seven. Finished the week at two hundred nineteen point eight, two pounds lighter.
Left the patches on overnight, which trimmed total sleep time so I stayed under seven hours for several nights. Felt slightly more on edge lately, likely tied to stopping the nicotine, and skipped two evening blood pressure checks. Focus seemed a touch sharper with the nicotine. The whole run felt fine, though I would steer clear of suggesting it to anyone who already kicked a nicotine habit.
A coworker mentioned two out of six people dealing with intense nightmares from wearing patches overnight at his previous job.
Next week I will try mirabegron and am curious whether it cuts down on waking up to use the bathroom.
In the next few weeks I plan to try several substances that fall outside the GLP-1 class while staying on retatrutide, and I will track both the measurable shifts and my personal impressions during that time right here. At 48 I have spent most of my adult years carrying extra weight yet staying active through sports I began as a kid. There were stretches when my conditioning was solid and my lifts reached solid numbers, but the usual pattern has been sitting 30 to 40 pounds above what felt ideal. A quick recap of my path with these medications this year starts after returning from a family trip near the end of June. I began a compounded version of tirzepatide at the suggested schedule that roughly matched the branded guidelines. My starting mass stood at 251 pounds. By the first of August the scale showed 235.9. I then moved to retatrutide at 1 mg twice weekly for a couple of weeks before raising it to 2 mg twice weekly for the following pair of weeks. My lifting plan stayed steady with heavy circuits of three sets of twelve across ten movements three times each week, plus daily walks that usually exceeded fifteen thousand steps. I kept added sugars low, hit roughly two-thirds of my body weight in protein, and stayed on top of fluids and salts. After beginning MOTS-C I noticed a clear change at the level that worked for me, 2.5 mg twice weekly. Roughly seven days later I added methylene blue at 4 mg each morning and felt another small lift in daily energy. On the first of September the reading was 228.2. With some of the earlier tirzepatide still on hand I moved to 3.3 mg on Wednesday afternoons paired with 2.1 mg of retatrutide on Sunday mornings. Around that point I started SLU at about 1 mg twice daily and soon raised it to 2 mg twice daily. The effect was subtle, though recovery between sets during workouts felt quicker. After finishing four weeks on MOTS-C I paused it and began SS-31 at 1 mg each day. Even when I raised the amount to 5 mg nothing stood out. Strength in the gym has been climbing gradually, slower than similar effort produced when I was younger. By the first of October the scale read 224.5. I had just added injectable 5-amino-1mq at 1 mg twice daily and later increased that to 2 mg twice daily, testing higher amounts at times since no clear difference appeared, much like earlier trials with NAD precursors. The goal was to avoid a full plateau while keeping the tirzepatide and retatrutide split, with the retatrutide dose moving up to 2.25 mg per injection after switching vials. Early that month the latest blood panel showed several improvements since July: A1C moved from 6.1 to 5.4, LDL from roughly 160 to 140, triglycerides from 145 to 110, HDL rose a bit, and liver values that had sat at 70-80 dropped into the normal range for the first time on record. Hematocrit had been near the upper limit in July so I donated blood and saw a further small drop. Inflammation markers came back low, and fasting insulin at 14.x translated to an insulin-resistance score of 3.0, the bottom of the significant range. I wanted to see further gains there. Throughout October I wore a portable heart monitor because of occasional episodes resembling Wolff-Parkinson-White patterns, which led me to drop any supplements that might influence the cardiovascular system beyond the GLP-1 medications. I ended SS-31 early in the month with no noticeable change, paused several over-the-counter items including berberine and methylene blue, and allowed my eating to drift back toward higher carbohydrates and more frequent higher-calorie days, including plenty of Halloween treats. I settled on running this new round of tests during October and lined up the compounds. On the first of November the scale showed 222.7. I was pleased that any loss occurred at all given the relaxed approach that month. My home reading that day was 221.8 in underwear, which lines up closely with the professional measurement. Body-fat percentage had been dropping about two points each month until October, when it edged up by 0.1. The last of the tirzepatide supply ended right at the close of October, so some amount will still be present alongside retatrutide through most of November. The list of items I will use this month, with the additions noted, is as follows: berberine 800 mg in the morning and optionally again if the day includes extra sugar; nicotinamide riboside 500 mg in the morning on days I take 5-amino-1mq until that runs out in about ten days; SLU-PP-332 roughly 10 mg twice daily under the tongue; urolithin A 500 mg twice daily alongside it; CoQ10 200 mg twice daily with the same timing; HMB free acid 3 g daily; zinc 30 mg each morning; boron 10 mg each morning; tongkat ali 200 mg each morning; a daily multivitamin gummy in the morning; shilajit 300 mg each morning; ginseng 50 mg each morning; turmeric 25 mg each morning; one scoop of colostrum; taurine 1 g in the morning; vitamin E 90 mg each morning; lutein 20 mg each morning; zeaxanthin 2 mg each morning; astaxanthin 6 mg each morning; MOTS-C 2.5 mg twice weekly; melanotan II about 320 mcg twice weekly; 5-amino-1mq 1 mg twice daily five days on and two off; kisspeptin-10 100 mcg twice daily five days on and two off; omega-3 fatty acids 1040 mg in the evening; and each night a tea containing citrus bergamot roughly 750 mg, creatine 5 g, magnesium citrate 500 mg, taurine 1 g, ashwagandha root about 750 mg, and glycine 1 g. The October averages I will compare against come mostly from the arm-worn monitor: blood pressure 124 over 81, resting heart rate 67, HRV 28, sleep score 68, stress score 37, and ending weight 221.8.