CommunityStacking & Switching

For Science! (reta + stacking)

18 replies6 peopleNov 8, 2025☆ Follow
Summary

What happens when stacking non-GLP-1 compounds like nicotine patches, mirabegron, kisspeptin, ATX-304, clenbuterol, and tesofensine with retatrutide for weight loss?

One user tracked weekly experiments adding compounds one at a time while on reta, recording weight, sleep, HRV, blood pressure, and subjective effects. Nicotine gave mild changes with stable BP; mirabegron helped nighttime urination but little else noted; kisspeptin improved EQ quickly; ATX-304 produced extra weight loss but also lean mass drops on scans; clen raised heart rate and sweating as expected. Later replies compared alternatives like albuterol or modafinil and discussed dosing caution due to half-lives.

What this discussion establishesWhere people disagree

Some view clen as too risky due to potential heart thickening even at normal vitals, while others prefer shorter-acting albuterol or non-stimulant options like modafinil.

Still open

Whether observed lean mass losses with ATX-304 are repeatable or dose-dependent, and long-term hormone or metabolic outcomes after multiple stacks.

Nothing here is advice.

18 replies · 6 people
SlowKettle51archiveopening postNov 8, 2025

In the next few weeks I plan to try several substances that fall outside the GLP-1 class while staying on retatrutide, and I will track both the measurable shifts and my personal impressions during that time right here. At 48 I have spent most of my adult years carrying extra weight yet staying active through sports I began as a kid. There were stretches when my conditioning was solid and my lifts reached solid numbers, but the usual pattern has been sitting 30 to 40 pounds above what felt ideal. A quick recap of my path with these medications this year starts after returning from a family trip near the end of June. I began a compounded version of tirzepatide at the suggested schedule that roughly matched the branded guidelines. My starting mass stood at 251 pounds. By the first of August the scale showed 235.9. I then moved to retatrutide at 1 mg twice weekly for a couple of weeks before raising it to 2 mg twice weekly for the following pair of weeks. My lifting plan stayed steady with heavy circuits of three sets of twelve across ten movements three times each week, plus daily walks that usually exceeded fifteen thousand steps. I kept added sugars low, hit roughly two-thirds of my body weight in protein, and stayed on top of fluids and salts. After beginning MOTS-C I noticed a clear change at the level that worked for me, 2.5 mg twice weekly. Roughly seven days later I added methylene blue at 4 mg each morning and felt another small lift in daily energy. On the first of September the reading was 228.2. With some of the earlier tirzepatide still on hand I moved to 3.3 mg on Wednesday afternoons paired with 2.1 mg of retatrutide on Sunday mornings. Around that point I started SLU at about 1 mg twice daily and soon raised it to 2 mg twice daily. The effect was subtle, though recovery between sets during workouts felt quicker. After finishing four weeks on MOTS-C I paused it and began SS-31 at 1 mg each day. Even when I raised the amount to 5 mg nothing stood out. Strength in the gym has been climbing gradually, slower than similar effort produced when I was younger. By the first of October the scale read 224.5. I had just added injectable 5-amino-1mq at 1 mg twice daily and later increased that to 2 mg twice daily, testing higher amounts at times since no clear difference appeared, much like earlier trials with NAD precursors. The goal was to avoid a full plateau while keeping the tirzepatide and retatrutide split, with the retatrutide dose moving up to 2.25 mg per injection after switching vials. Early that month the latest blood panel showed several improvements since July: A1C moved from 6.1 to 5.4, LDL from roughly 160 to 140, triglycerides from 145 to 110, HDL rose a bit, and liver values that had sat at 70-80 dropped into the normal range for the first time on record. Hematocrit had been near the upper limit in July so I donated blood and saw a further small drop. Inflammation markers came back low, and fasting insulin at 14.x translated to an insulin-resistance score of 3.0, the bottom of the significant range. I wanted to see further gains there. Throughout October I wore a portable heart monitor because of occasional episodes resembling Wolff-Parkinson-White patterns, which led me to drop any supplements that might influence the cardiovascular system beyond the GLP-1 medications. I ended SS-31 early in the month with no noticeable change, paused several over-the-counter items including berberine and methylene blue, and allowed my eating to drift back toward higher carbohydrates and more frequent higher-calorie days, including plenty of Halloween treats. I settled on running this new round of tests during October and lined up the compounds. On the first of November the scale showed 222.7. I was pleased that any loss occurred at all given the relaxed approach that month. My home reading that day was 221.8 in underwear, which lines up closely with the professional measurement. Body-fat percentage had been dropping about two points each month until October, when it edged up by 0.1. The last of the tirzepatide supply ended right at the close of October, so some amount will still be present alongside retatrutide through most of November. The list of items I will use this month, with the additions noted, is as follows: berberine 800 mg in the morning and optionally again if the day includes extra sugar; nicotinamide riboside 500 mg in the morning on days I take 5-amino-1mq until that runs out in about ten days; SLU-PP-332 roughly 10 mg twice daily under the tongue; urolithin A 500 mg twice daily alongside it; CoQ10 200 mg twice daily with the same timing; HMB free acid 3 g daily; zinc 30 mg each morning; boron 10 mg each morning; tongkat ali 200 mg each morning; a daily multivitamin gummy in the morning; shilajit 300 mg each morning; ginseng 50 mg each morning; turmeric 25 mg each morning; one scoop of colostrum; taurine 1 g in the morning; vitamin E 90 mg each morning; lutein 20 mg each morning; zeaxanthin 2 mg each morning; astaxanthin 6 mg each morning; MOTS-C 2.5 mg twice weekly; melanotan II about 320 mcg twice weekly; 5-amino-1mq 1 mg twice daily five days on and two off; kisspeptin-10 100 mcg twice daily five days on and two off; omega-3 fatty acids 1040 mg in the evening; and each night a tea containing citrus bergamot roughly 750 mg, creatine 5 g, magnesium citrate 500 mg, taurine 1 g, ashwagandha root about 750 mg, and glycine 1 g. The October averages I will compare against come mostly from the arm-worn monitor: blood pressure 124 over 81, resting heart rate 67, HRV 28, sleep score 68, stress score 37, and ending weight 221.8.

SlowKettle51archiveNov 8, 2025

Began testing with nicotine patches at seven milligrams over the first seven days. I figured on a modest uptick in metabolism, some rise in blood pressure, and maybe clearer thinking. Never developed a smoking routine myself, though I dabbled briefly as a teen without getting hooked.
Raised the reta amount to three milligrams at the start of the month and aim to stay at three milligrams twice weekly until hitting just under two hundred pounds. Felt a faint skin itch for the first time, yet it faded within roughly half a day.
Eating habits are mostly back in line, probably landing between seventeen hundred and two thousand calories without exact tracking. Cutting back on sugars while falling short on fluids this week.
Stats showed average blood pressure at one seventeen over seventy two, lower than anticipated, resting heart rate of sixty eight, HRV twenty eight percent, sleep score sixty six, deep sleep twenty seven percent, and stress at thirty seven. Finished the week at two hundred nineteen point eight, two pounds lighter.
Left the patches on overnight, which trimmed total sleep time so I stayed under seven hours for several nights. Felt slightly more on edge lately, likely tied to stopping the nicotine, and skipped two evening blood pressure checks. Focus seemed a touch sharper with the nicotine. The whole run felt fine, though I would steer clear of suggesting it to anyone who already kicked a nicotine habit.
A coworker mentioned two out of six people dealing with intense nightmares from wearing patches overnight at his previous job.
Next week I will try mirabegron and am curious whether it cuts down on waking up to use the bathroom.

KeenLantern39archiveNov 8, 2025

Recording experiment stats and how far along things have gotten feels like a really helpful contribution around here. Glad you put in the effort for it. I like the way extra compounds get brought in gradually instead of dumping them all in together. Man, that's a big collection! The empty markers look useful, though editing stops after some random cutoff date.

SlowKettle51archiveNov 8, 2025
↳ replying to @KeenLantern39

Appreciate the warning on how the edit option fades away fast. Deleted those draft entries already, and from now on I'll share new details every week.

PatientPebble85archiveNov 10, 2025

Appreciate the detailed message you shared. It shows dedication to improving health and shedding pounds. Nice work reversing the prediabetes through better A1c numbers. Wondering about your take on kisspeptin. Any noticeable side effects tied solely to using it, or has everything gone well? Reports suggest it might boost male libido. Seen any changes there? Thinking it could serve as an option prior to starting testosterone therapy. My free testosterone level sits at three, which seems quite low. Hesitant to begin with anabolic substances right away. Experimenting with ipamorelin instead, yet kisspeptin appears better suited. Curious what others have experienced with it.

SlowKettle51archiveNov 10, 2025
↳ replying to @PatientPebble85

Polypharmacy complicates figuring out kisspeptin's role at this point. I've reached the second day of the second week with it. Extreme tiredness hit me over the last two days. Work kept me busy without breaks the previous week, and tasks felt tougher than normal. Raising my reta amount might explain the tiredness too. Maybe quitting nicotine plays a part, or perhaps mirabegron caused an unforeseen reaction. Hard to know for sure. Since beginning kisspeptin, my erectile quality stayed solid. Waking up with strong erections happened during nights and mornings after the initial pins. Even with heavy fatigue, my partner wanted intimacy tonight, and things went well. Blood tests are scheduled for early December to monitor hormones against pre-cycle levels.

PatientPebble85archiveNov 10, 2025

That's awesome!! This has me laughing hard!!

SlowKettle51archiveNov 15, 2025

Finished the second week on fifty milligrams of that medication each day. I figured not much would happen beyond a possible small rise in blood pressure. I wanted to stay asleep all night without bathroom trips. The drug treats overactive bladder by easing tension in its muscle layer. That ties into fat loss because it activates beta three receptors. Its relative clenbuterol hits the beta two version instead. Taking this compound turns ordinary fat into a more active brown type that burns energy faster. One trial with a single larger dose raised daily calorie use by about two hundred. It avoids the harsh reactions tied to the other drug until doses climb high enough to affect those other receptors. Common issues include higher pressure readings, head pain, bowel slowdown, lightheadedness, stomach upset, and mouth dryness. Overall the week went fine. It was also the second week shifting my other dosing schedule up to six milligrams of the second glp one item. I take half a milligram of the third peptide alongside each shot. Appetite stayed fully in check, matching my strongest stretches on the first glp one alone. Food totals stayed close to the prior week except more came early because of cereal bowls and one morning of waffles. Rest stayed average at seven hours. Deep sleep lasted roughly four hours before a bathroom break, then lighter rest afterward. The opening nights without nicotine and with the new med brought restless energy that might have kept an anxious person awake. Headaches showed up more often than usual, matching one listed effect. Pressure edged up a bit as expected. Bathroom trips continued every night anyway. Sleep tracking covered only five nights because the band came off once after a shower and flipped another time. Pressure sat at one twenty one over seventy nine. Resting pulse averaged sixty eight. Heart rate variability sat at twenty five percent and slipped lower by the end. Sleep quality score averaged seventy six. Deep sleep portion reached twenty nine percent. Stress score averaged thirty seven. Final weight landed at two nineteen, down eight tenths of a pound. Sleep edged better than the nicotine week while fat loss slowed a touch, though earlier readings sat near two seventeen before some late chips possibly added water. The metabolic boost here should keep working longer than the prior aid. Variability dropped across the days, possibly from added load of the other items in use. Testicles felt slightly sore and maybe enlarged, likely tied to the kisspeptin trial still running three more weeks until labs. For the next stretch I plan to begin one hundred fifty milligrams daily of the newest item.

SlowKettle51archiveNov 22, 2025

Made it through the third week without issues. Daily intake of the compound fell in the 150 to 300 milligram range. I measured portions roughly by eye using a small spoon since I had the loose powder form and simply tipped it straight into my mouth before rinsing with water. The material repels liquid and stays separate from most drinks. It left no odd sensation or strong flavor behind. Going in I felt roughly even odds that the material might prove ineffective. Although fairly recent in these circles the molecule itself dates back years with published work from 2015 onward. It started under one label before a development firm acquired rights and issued a new name. Human testing continues with the most recent updates from 2023. The compound turns on the AMPK route that shifts metabolism toward using stored fat. It also acts as a gentle uncoupler at the cellular power plants which forces them to expend extra effort and burn additional fuel. This resembles the pathway behind older uncoupling agents though this version supposedly includes built-in limits that prevent runaway overheating. Trial records list 150 milligram amounts while other accounts mention single intakes reaching 600 milligrams so I stayed well under that level. A separate worry involves prolonged AMPK signaling that may reduce muscle retention during fat loss. In practice the substance produced clearer sensations than prior items I had tried. I took it in the middle to late part of the day instead of a second portion of the earlier compound. Roughly sixty minutes later body temperature readings rose by half a degree to a full degree. Sleep quality dropped sharply at the outset with four or five nights of restless vibration-like feelings once I lay down. Metrics on my tracker showed gradual gains across heart rate during rest heart rate variability and deep sleep share as the week progressed which I attribute to quick adaptation. Extra time in bed helped offset the disruption. Bathroom trips doubled at night for those same initial nights and one more occurred upon waking suggesting a mild fluid loss effect. On the seventh day bowel habits shifted from several weeks of firmness to loose stools though the link remains unclear. Daytime hours brought no major shifts in how I felt. Overall the material appears effective for fat reduction though cost per gram sits higher than some alternatives and requires larger amounts for comparable impact. Average readings for the period included blood pressure at 116 over 75 resting pulse near 69 variability at 25 percent sleep score around 73 deep sleep portion near 25 percent and stress near 35. Final scale reading reached 215.8 pounds for a 3.2 pound drop. The opening two evenings included an added blend taken with my partner after I mixed in 5 milligrams of another peptide but any sleep influence seemed minor. Week four will involve clenbuterol which carries a divided reputation yet has a known track record for fat loss. The holiday timing means large meals are likely so the focus stays on tracking personal responses and metrics rather than direct comparisons. Daily amounts will follow the common 40 microgram level.

RustHarbour17archiveNov 22, 2025

Wow, that's quite intriguing. I've done a fair amount of research into DNP. The initial discovery happened with ladies employed in a French explosives facility back in the Great War, and they dropped a lot of pounds simply from contact with it in the air. Been checking out info on SLUP as well as SLUP combined with BAM. Really cool, but I have a feeling that vibrating body thing would probably unsettle me quite a bit.

SlowKettle51archiveNov 30, 2025

Finished the fourth week on that famous stimulant compound known for cutting phases over many years. This substance activates certain beta receptors in the body and shows minor activity on others tied to fat tissue changes. It started out as a treatment for breathing issues and remains in use for that in select places. With newer options now around some longtime users have moved away from it due to the range of possible reactions. Those can involve faster pulse elevated pressure stronger hunger trouble resting shaky feelings and tight muscles. I figured the week might feel off so I stuck with the standard starting amount each morning. Early days passed without much issue though sweating picked up during a game and recovery metrics shifted during rest right away. Hunger rose a bit yet stayed manageable alongside my other routine just noticeable overall. Extra stimulation did not hit hard on its own but adding coffee made things feel stronger with jitters and mild stomach upset. Rest took a clear hit with the two worst recovery readings so far on my tracker both in the low forties. One night I woke early and stayed awake the other came after long late driving which explains part of it. Even decent nights felt less restorative. Muscle tightness showed up around day three or four with lingering soreness mostly in the lower body. Some research points to possible tissue building effects likely from tiny ongoing contractions similar to a faint tremble. Light shaking appeared when holding an object steady but stayed unnoticeable in normal movement. The final days involved plenty of downtime so no actual spasms occurred. I kept quinine water handy just in case after hearing it can ease them fast. Scale movement reversed this week yet the prior ending point returned by midweek meaning the gain came from the last couple days. I doubt the extra intake reached ten thousand calories but perhaps six thousand plus fluid retention. Pressure averaged lower than expected at 110 over 68 while pulse sat at 75 and variability at 22. Recovery score averaged 58 with deep rest at 26 percent and tension at 36. Final weight reached 218.6 for a net gain of 2.8 pounds. Pressure behaved opposite to common warnings. Looking into studies and reports shows mixed findings with some data indicating drops at certain amounts depending on the person. It clearly reduced mine here. Overall another cycle seems worth trying since the reactions stayed tolerable though better rest would help. The compound works more directly than recent alternatives for fat loss. Next week I plan to test a different option focused on hunger control after pausing one part of my stack to check that aspect alone. I will also set aside the other supplement because of overlapping actions.

SharpCinder28archiveNov 30, 2025

I liked clen a lot for a short period. Others considered me odd for that. Unfortunately clen has many uncertainties. Oral albuterol seems less dangerous as an alternative. It resembles clen closely yet lasts much less time in the body, with duration reduced by over eighty percent from thirty two hours down to five. When aiming for muscle building results raising testosterone appears less hazardous and happens more often. Testosterone replacement works better than clen for those goals. Among stimulants I prefer modafinil because it provides energy and may reduce hunger while having fewer risks. Mostly though I stick with caffeine. What surprised me about clen was its potential to thicken the heart walls despite normal pressure and pulse. Anabolic steroids do this too even when testosterone exceeds typical levels. Research on beginners using these substances noted a five percent drop in heart performance after sixteen weeks of heavy use but it recovered within eight months after cessation.

SharpCinder28archiveNov 30, 2025
↳ replying to @SlowKettle51

I've found it intriguing. For muscle cramps during steroid cycles, taurine along with electrolytes has helped me out. I've wanted to experiment with teso soon. An oral liquid version makes adjusting the amount simpler, particularly if I aim for smaller quantities to lessen unwanted effects.

SlowKettle51archiveNov 30, 2025
↳ replying to @SharpCinder28

Since my usage period is limited to seven days, capsules seemed like the better choice for me. My guess is that others ran into trouble with the side effects because of the extended duration it stays in the system combined with ongoing intake, or perhaps they started with larger amounts before noticing any impact.

KeenKettle50archiveApr 26

I'd rather avoid reviving an old discussion yet any fresh details on ATX 304 would be welcome since the whole thing has my strong attention.

SlowKettle51archiveMay 4
↳ replying to @KeenKettle50

Sure thing. I may add more details later about tests I've conducted over the past few months. This marks my second attempt with the substance. From what I've seen, it leads to extra fat reduction alongside regular efforts, given that I noticed further pound loss during both periods of use. However, those same periods coincided with my body scans showing a clear reduction in muscle tissue. Some additional supply is en route, which I intend to access sporadically for a metabolic reset.

KeenKettle50archiveMay 6

That's cool! How did you eat during that time? Did you check out other things too? Planning to try the BAM 15 shot pretty soon myself.

SlowKettle51archiveMay 14
↳ replying to @KeenKettle50

During my October experiment my eating was quite restricted in carbohydrates since I wanted better insulin response. The next attempt involved a more even approach to meals mostly at maintenance calories or slightly under. For some time in that phase I used a larger amount of SLU in fifty milligram pills. I've concluded this amount is excessive for my system and plan to try a lower daily intake of ten milligrams instead. Initially with the higher dose I noticed positive effects and improved endurance in aerobic activities but soon felt fatigued likely from excessive mitochondrial activity. Both periods with the ATX compound I also used retatrutide at a consistent level around five to six milligrams each week. Around when I posted about it the initial human data for ATX-304 came out. My use was based on animal research and it's encouraging that it appears effective and safe for people. Further reading shows ATX-304 has many similarities with Rapamycin since they are strong inhibitors of mTOR. A recent crowd-funded investigation with Rapamycin indicated reduced muscle development compared to the control when taken weekly. Rapamycin lasts about sixty hours in the body while ATX-304 is closer to thirty to thirty six. From my experiences and that research I think combining ATX-304 with a GLP-1 will lead to reductions in both fat and lean mass which is worth noting. Currently I'm working on balancing my mTOR and AMPK pathways. My approach is to have a day and a half focused on mTOR after my weight training in the afternoon every third day then switch to a day and a half of AMPK emphasis. On the first morning of the AMPK phase I'll use one hundred milligrams of ATX-304. I'm continuing body recomposition aiming to reach below two hundred pounds from my current two hundred twelve and having gone under twenty percent body fat I might be satisfied around fifteen percent before hitting the weight goal.

KeenKettle50archiveMay 14

Sarcasm intended here. Yet one more substance requiring an injection that supposedly won't kill me. Appreciate the suggestions though. My current approach involves plenty of protein with some carbs but minimal fats while lifting weights. So I have no plans to try that substance anymore.

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