Should I move up to 4mg on Reta?

Raise the amount only as far as side effects allow.

Go up more gradually. Plenty of people do not give the medication enough time before deciding it is not working.

I moved straight to four after four weeks at two. In hindsight I regret it. Resting heart rate was already a bit higher at two, but at four my sleeping rate hit eighty and eighty-two the last two nights. If you are not already logging resting and sleeping heart rate, collect a couple weeks of numbers before going to four.

It is unfortunate that the response is not stronger. There is no clear reason not to try three milligrams next and observe.

I notice better appetite control and less constant hunger when I split the dose into two shots per week, Sunday and Wednesday at one point five each.

You have only now reached the starting level used in the company study. No reason to wait more than two or three weeks before going up. Slow and low is not always the best approach; sometimes it underuses the medication.

My take is that if weight is still coming off at least half a pound a week, stay put. Slow progress adds up. Only move up half to one milligram after four weeks with no loss. The goal is the lowest dose that works and is tolerable. Responses vary widely; someone I know dropped eighty pounds in nine months on just two point five.

If I recall correctly the drug reaches steady effect around five weeks. Jumping to four means adding more while the earlier amount has not yet peaked. That is why most people hold each level for a full month. At only four weeks on two there is no need to move yet. Another week at two, then a few at two point five, then three. This is a long process. When the dose is right you will simply know.

Grateful for everyone's input here. Patience is key for me at the moment. I'll stick with 2mg.

It is striking how differently it hits people. I began at one and held it five weeks. The first week food was unappealing and I lived on protein shakes, dropping twenty pounds with little visible muscle loss. I am also on one hundred milligrams of HRT. The last two weeks I went to one point five. Because of the half life the amount in the body keeps rising even if the weekly shot stays the same. That is why the advice is to hold four weeks and only increase if sides are manageable. I am convinced the design allows hunger to return so you can refuel for the glucagon effect, so hunger alone is not a good gauge. Also drink plenty of water because water weight shifts the scale.

Whether to increase depends on side effects, rate of weight loss, and hunger. If hunger makes it hard to stick to the plan and sides are minimal, going up makes sense. If sides like nausea are already present at two, move slower or hold. If loss is acceptable and hunger is controlled, stay. Your current level will not reach its highest point for nearly four more weeks, so remember you have really only had one full week at two after the earlier steps. Starting BMI around thirty four means higher doses will probably be needed later, but moving after only one week at two raises the chance of sides. I would not go straight to four after one week at two. Three might be reasonable if hunger is strong and sides are light.

The people here make this place special. I am grateful to everyone who offered their opinions. It shows how we support each other through everything.

I know it is not the usual way, but week one I used one, week two two, week three three, and week four the vial ran out so I did one point five. When the new kit came I went back to three for week five. It feels like I may be getting used to it because the last dose produced even less effect than before. Maybe the new kit is weaker. Should I go to four this week?

A sensible rule is to keep the same amount for four weeks and move slowly. Just because the trials started at two and stepped by twos does not mean everyone must copy that.

Very little. I did not get sides with the earlier one either, but hunger was more controlled even though I can manage it anyway.

Side effects from these medications differ a lot between people. A dose that causes a week of vomiting for one person may be barely noticed by another, though at higher levels the difference usually becomes clearer. Different compounds can also produce unexpected results; one person had strong nausea on very small amounts of one but almost none from four point five of another. The fact that some appetite suppression occurred is a sign the medication is active. From reading experiences here, people who carry less excess weight often notice effects and sides at lower doses than those carrying more. Because the half life is six to seven days, any unpleasant effects can linger for days or more than a week, which becomes a problem if vomiting or diarrhea leads to dehydration.

I also began at two milligrams a few months ago and moved to four, where I have stayed. Results vary, but the advice is to remain at the lowest dose that works. Losing too quickly can lead to loose skin. Some consider adding tesamorelin for better outcomes.

Here is the schedule I used and decided to remain at five. Week one half, two one, three one point five, four two, five two again, six two point five, seven three, eight three again, nine three point five, ten four, eleven four again, twelve four point five, thirteen and fourteen four point five, fifteen and sixteen five.

I didn't rush things and eventually noticed the outcomes I wanted.

I think, and this is my opinion. Everyone wants an instant rock hard twenty one year old body, lose one hundred pounds fast and do not want to wait.