Stacking semaglutide with retatrutide or tirzepatide after appetite return or stalls

I don't have any medical background. The only detail I can share is how the beginning amount for this medication starts at point two five milligrams. Even with such a low quantity at the outset, back when I first tried it on myself I dealt with some trouble staying regular. In the end the choice of how much to use rests with you alone since you'll handle whatever comes next.

I considered the possibility at first, yet a video from a physician indicated dividing doses leads to quicker loss of receptor sensitivity. Including the other compound probably is not ideal either, even though it influences just one route while this one influences three.

I checked out the video once more, focusing on the section about dividing doses this round. The overall average amount stays unchanged, yet this method does lower the highest points while lifting the lowest ones. Calculations shared elsewhere confirm the mean exposure holds steady even as those extremes flatten out. Taking 1mg twice weekly leads to a high of 3mg, low of 2mg, and mean of 2.5mg. Daily portions around 0.285mg produce a high of 2.62mg, low of 2.33mg, with the same mean. Biweekly shots of 4mg create a high of 5mg, low of 1mg, again with that mean. The speaker claims dividing doses pushes more receptors toward the lysosome from overuse, though the reasoning stays unclear. The average concentration matches either way. Some note that lower points between shots give recovery time, while higher ones could cause burnout if that occurs. The steady mean exposure stays identical regardless. Side effects seem to follow the high points, while the low points affect how well it performs. Dividing my own doses has kept unwanted effects down to almost nothing. Appetite stays in check with fewer intrusive thoughts about food, weight has dropped steadily, usual macros continue without extra effort, and I still manage daily movement that burns at least 500 calories beyond routine activity. I am moving from Tirz over to Reta. I began dividing doses around three and a half weeks into the 2.5mg Tirz phase once food thoughts returned midweek, took the fourth shot then, and shifted to splitting 5mg weekly ahead of the switch. My peak reached 5.6mg on Tirz and 5.7mg on Reta so far. Weight is down 18 pounds after 40 days, a touch quicker than targeted but still acceptable. I expect to finish Tirz shots sometime next month, though I am just following along. What dose and readings are you at now with Reta?

I break my Reta amount in half for two days during the week and add other things on top of that.

Right now I'm on four milligrams yet progress has halted for more than a week and the scale shows an extra two pounds. My next shot will move up to five milligrams. I really hope I can avoid climbing past six milligrams later on. Several others have mentioned good results from combining those two compounds and I may try the same approach sometime in February.

Concerned about receptors getting burned out yet still hoping to combine those compounds. The standard doses that deliver typical advantages show up near six to eight milligrams or above. Holding steady for seven days does not seem like much and a couple pounds might reflect fluid or daily fluctuations on the scale. Your choice entirely of course I am simply examining the reasoning behind it.

I would do them separately.

Have you kept dropping pounds? After reaching my target I started using reta much later. Appetite rose quite a bit and the scale moved up during what felt like the first couple weeks yet returned to my usual level and held steady. Everyone reacts differently. Despite how popular it is right now I simply let reta handle things on its own. If adding other compounds appeals there's always room to try that down the line.

My progress has stopped and I've added roughly two pounds across just over a week. I recently raised the amount to five milligrams and now expect the pounds to start dropping once more. I'll hold off for up to a month before trying other steps unless further changes show up.

Back when my progress on tirzepatide started to slow down, I wanted to add something else to the mix. Online suggestions pointed toward reta, but since I hadn't come across this spot yet, I went ahead and got semaglutide. The usual recommendation seems to involve gradually raising the sema amount while lowering the tirz, taking it easy to monitor personal reactions. For me, that worked out like this: between the start of June and December, I dropped 27 pounds at about one pound each week. Then from December through early February, another 20 pounds came off at roughly two and a half pounds weekly. I began combining them around the first of December, which ended the plateau and got things moving again. I kept my tirzepatide amount the same and just add 1mg of sema every third day.

Hey. Trying to confirm if I read your comment correctly. You raised the Sema amount to 5mg with your RS? I recall seeing some research on larger Sema doses.

Currently I'm taking five milligrams of Reta and expect to raise the dose to six milligrams shortly. Once there I'll bring in two hundred fifty micrograms of Sema if my weight reduction stops progressing.

Glad for the explanation. Hoping everything works out great for you!

I'm using ten milligrams of tirzepatide right now. Thinking about trying a little semaglutide three days after the shot. Wonder if adding that part shows up noticeably.

These days my Friday dose is 16 or 17 milligrams of tirzepatide. Then the following Monday I add half to one milligram of semaglutide, picking the exact amount according to how I feel at the time. I notice the semaglutide quite clearly and really enjoy the effect it gives. Adding the two together also ended a plateau I had reached. I still held off on combining them until I had already reached the top amount with the first one alone.

Wow, that's really impressive progress! My own drop of 103 took a full 14 months, so you're moving ahead much quicker. I pair a modest sema amount with 16mg tirz yet consider trimming the tirz back a bit while raising the sema instead. I have no issue exceeding FDA limits and wonder what higher sema target you have in mind.

My partner and I have dropped roughly equal pounds so far. Personally, I notice a huge improvement in how I feel overall. I no longer require any extra oxygen, an old bedsore that persisted for years has now closed up entirely, and the swelling in my lower limbs has decreased along with those fluid-filled sores that used to ooze. It feels like I'm starting over with better health. There are studies out there looking at higher weekly amounts reaching 16 milligrams per week. I hope I can avoid going that far because once I near my target, I'll probably lower the amount for upkeep. I'm open to staying around 10 to 12 milligrams weekly, provided I can keep losing one or two pounds each week on average when looking at monthly trends.

The information is pretty much available now thanks to the STEP UP study in phase 3b. From that, the 7.2 mg dose got official approval in the EU just a few days ago, and the UK approved it earlier. I get what you're saying about the testing group problem... 😐

Oh, I hadn't checked out approvals around the world for higher doses. Thanks a lot!!!! I don't believe the FDA is more cautious; actually they might be less so.

In the past I stacked 0.1mg of Sema with 6mg of Tirz, and even at these low amounts it worked really well for me on hunger suppression. Now I'm switching from Tirz to Reta and have stopped Sema. But once the Tirz is out of my system I'll add sema back in.

Haha. Taken out of context for laughs.

I took .75mg of sema about an hour ago and I'm definitely noticing it. I had 15mg of tirzepatide last Friday, so yeah, even small doses of sema hit me. I've been unsure about my stack and this morning I decided to focus more on the sema. I'll start raising the sema dose each week while lowering the tirzepatide. Though I've already been on tirzepatide for 14 months and above the max FDA dose for some time.

Gonna get that exorcized 😅

What's interesting to me is that at higher Sema doses (1mg to 2mg) I didn't get the same hunger suppression as with 6mg of Tirz plus 0.1mg of Sema. That combo worked really well. I switched to Reta because increasing Tirz (even with the same Sema dose) caused strong fatigue... and I wasn't a fan of that.