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Stopping Retatrutide, Semaglutide, or Tirzepatide

19 replies14 peopleJun 16, 2026☆ Follow
Summary

What happens to hunger, weight, and maintenance when stopping or coming off GLP medications like retatrutide, semaglutide or tirzepatide?

Most users in the thread plan to stay on a maintenance dose indefinitely rather than stop completely, citing strong hunger return, high likelihood of weight regain, and extra health benefits. Tapering slowly or spacing doses farther apart are the main suggested exit approaches, though studies show most people regain weight when taken straight to zero. Those who have tried stopping report significant rebound, while others note that prior habits and consistent training influence outcomes.

What this discussion establishesWhere people disagree

Whether gradual tapering can meaningfully improve long-term success rates compared with the abrupt cessation used in existing studies

Still open

What the safest or most effective long-term maintenance dose or schedule actually is for most users

Nothing here is advice.

19 replies · 14 people
NorthThistle12archiveopening postJun 16

Hello everyone, three months into my Reta run and everything feels solid so far. Down 7 kg, hitting calorie and protein targets, lifting five days a week plus cardio. All systems are working well right now. Still, I keep wondering what it will be like to eventually come off these injections, whether it is retatrutide, semaglutide or tirzepatide. Hunger is the big one people mention, saying it returns hard and food thoughts become constant. Was that your experience and how intense was it? Also curious how you actually stopped, cold turkey or by lowering the dose or stretching the time between shots. Finally, how has weight held up since you quit, any rebound, how long have you been off, and what helped with the changeover?

GreenMeadow54archiveJun 16

I went onto a low dose of Tirz for maintenance to keep food noise under control and expect to stay on it long term because it noticeably improves how I feel day to day. The better approach seems to be finding the smallest dose that keeps weight stable once you near your goal, then either lowering further or spacing shots out more. Moving from Reta to Tirz could also be worth considering since it appears gentler overall and carries extra health upsides. A long-term plan makes sense because people who simply quit GLPs usually regain the weight. Losing both fat and muscle on the way down, then regaining mostly fat on the way back up, is common and not ideal for health.

PlainAlder11archiveJun 16

Five pounds from goal after dropping 55 and starting to plan ahead. I will probably step down slowly from 8 mg to 4 mg then maybe 2 mg depending on how things go. I plan to keep using Reta as long as my supply lasts.

AmberCompass48archiveJun 16

It really comes down to how strong your hunger and food fixation were before you started losing. Some people drop fifteen pounds from one bowel movement, so if that is not you then you should be fine.

QuietSignal61archiveJun 16

Hard to find real experiences about stopping because most people here intend to keep going. If the medication stops working long term that would be a problem. From what I have heard, expect to gain around thirty pounds once you quit.

AmberCinder18archiveJun 16

I have no plans to ever stop Tirz because of the other benefits besides weight loss. Still a ways from goal, but the two main ideas at that point seem to be stretching doses out, with some reaching once a month, or slowly lowering until weight starts climbing again. The studies indicate most people will regain if they stop completely.

AmberCompass48archiveJun 16
↳ replying to @PlainAlder11

I was full of it, then dropped a fifteen-pound bowel movement and felt much better afterward. Losing just fifteen pounds would be easy for me. The original poster does not seem to have an out-of-control relationship with food, so their bowel movements are probably only about a quarter pound.

GreenMarble65archiveJun 16
↳ replying to @AmberCompass48

I can sit at the same weight for a couple of weeks, then have one big bowel movement and drop three pounds.

PatientTimber45archiveJun 16

Taper as slowly as you can because hunger returns hard and hits like a truck, so be prepared for that.

QuietThistle70archiveJun 16
↳ replying to @QuietSignal61

One hundred percent. The numbers on keeping weight off after stopping GLPs are just as poor as with regular diets. I have been through it. Hopefully long-term maintenance dosing stays as safe as it looks now and access stays affordable.

WarmSparrow60archiveJun 16

On 15 mg of Tirz for the past six months and that is my current maintenance approach. Also added 1 mg of Eloralintide. These kits are not going to use themselves.

PlainAlder11archiveJun 16
↳ replying to @WarmSparrow60

That is the problem with all the product I still have on hand. I will stay at 8 mg until about five pounds remain, but my wife has been on 8 mg and says it stopped working. I am still dropping one to two pounds a week so I know the Reta is fine. She will not weigh herself at all, so there is no way to track what is happening. She is moving up to 9 mg after five weeks at 8 mg.

GreyAlder96archiveJun 16
↳ replying to @NorthThistle12 (opening post)

The only people I know who quit GLPs successfully were only mildly overweight from poor habits and the medication helped them change those habits. Every study I have seen shows weight returning close to the starting point after stopping. Continued dosing kept weight off for about eighty percent of people, so even with ongoing use roughly twenty percent still regained some. Why would anyone want to stop when new benefits keep appearing, such as better insulin sensitivity, lower inflammation, and improved cancer survival rates? With affordable access it is hard to justify quitting. These medications finally let me bulk and cut properly instead of cycling through bad weight gain and crash diets. I am most ready to add muscle right after a cut, so maintenance is usually short for me. I thought I would taper to a lower dose but it looks like I need my current dose to hold steady.

NorthThistle12archiveJun 16
↳ replying to @GreyAlder96

I had not really considered staying on it long term or forever, but now I probably will. I am not severely overweight and have always trained, so that helps. I just enjoy eating a lot, which added some weight, and Reta made the diet easier. I used to follow the same diet without the medication but was constantly hungry. After this I will not bulk again because it is too tiring and time-consuming. I will definitely lower the dose or switch to every two weeks once I finish the cut.

BrightMeadow15archiveJun 16
↳ replying to @QuietThistle70

Because every study moved people straight from a full therapeutic dose to zero. That approach does not make sense. We do not do that with other long-term medications like SSRIs or blood pressure drugs, where tapering off is standard. If someone wants or needs to stay on forever that is fine, but the studies only tested one bad way of stopping. There are other ways to come off peptides.

WarmAnchor49archiveJun 16

Lifer. Trying to space doses farther apart but planning to stay on indefinitely.

PatientAlder89archiveJun 16
↳ replying to @AmberCompass48

Did that take place during the clean-out for your colonoscopy?

AmberCompass48archiveJun 16
↳ replying to @PatientAlder89

And every time I raise my dose on reta too.

PatientAlder89archiveJun 16
↳ replying to @AmberCompass48

At least you lost what you gained. Better than the opposite situation.

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