Fatigue like that shows up often on tirz, especially with low water or electrolytes, though it can happen even when those are fine. Running in a deficit also raises injury risk so be careful. I added BPC157 for that reason and it helped me. Some people mention mots-c for energy but I have not tried it.
Anyone here who runs also on tirzepatide? I split my dose with 3.5 mg Tuesday morning and 3.5 mg Friday evening. My schedule has weights on Monday and Thursday, yoga on Wednesday and Saturday, and runs on Sunday, Tuesday, and Friday. Right now I am doing couch to 5k with four-minute run and two-and-a-half-minute walk intervals. The Tuesday evening run is the problem because I have zero energy and cannot hold pace. Has anyone else noticed cardio feels worse on shot days? I am 35, started at 240, now 213.