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How soon to stop peptide blend before surgery?

13 replies10 peopleJan 24, 2026☆ Follow
Summary

How long before surgery should peptides and GLP-1s be stopped, and should they be disclosed to the surgical team?

Participants share personal timelines for stopping GLP-1s and other peptides ahead of procedures, with most settling on two to three weeks as a buffer. Several stress that anesthesia and healing risks make full disclosure essential, while others note insurance concerns or updated guidance that may allow continuation under monitoring. Half-life estimates vary from hours for some peptides to days for GLP-1s, leading to conservative cutoffs. The group ultimately favors erring on the side of caution and following medical instructions rather than forum guesses.

What this discussion establishesWhere people disagree

Whether patients should always disclose peptide use to surgeons versus withholding information to protect insurance coverage or avoid judgment.

Still open

Exact safe stopping windows for specific peptide combinations and how new anesthesia guidelines apply across different countries and procedures.

Nothing here is advice.

13 replies · 10 people
AmberCompass48archiveopening postJan 24

Surgery is scheduled for February 9 and the last GLP-1 injection was on the 22nd. It could probably be taken closer to the date but the preference is to avoid unnecessary risks. Daily BPC and TB-500 have been used for only two or three weeks so far, yet the plan is to try the other blend beforehand with the idea of continuing it afterward for recovery. Reconstitution is happening today, so the question is how far out from the operation it can safely be used and how soon afterward it can resume. The doctor will not be told about any of it because finding a primary care provider was already difficult and this one would likely disapprove of gray-market items.

ClearLantern81archiveJan 24
↳ replying to @AmberCompass48 (opening post)

This kind of post raises clear concerns. The surgical team and anesthesiologist really need to be aware of everything being taken because these substances are not ordinary supplements. They can influence inflammation, digestion, bleeding, wound repair, blood pressure, and anesthesia response. Seeking timing advice on a forum while planning to keep it hidden from the operating doctor is risky. Physicians focus on avoiding complications, safely handling anesthesia, and understanding anything that might affect clotting or recovery. If an issue arises without that knowledge, the chance of problems increases and treatment becomes harder. Worrying about judgment or losing a provider is understandable, yet this involves personal health and the upcoming procedure.

IronCinder46archiveJan 24

Here the blunt view has to be stated even if it sounds harsh. Ideally everything could be shared openly with the surgeon, but in practice the information might reach the insurance company, which could then refuse to cover the operation on the grounds that unapproved substances were used and might cause complications. It is an unfortunate reality when financial considerations override care.

LevelLedger10archiveJan 24

For personal use only, the approach would be to calculate four or five half-lives and then add extra time beyond that, such as another week for anything other than GLP-1s. If the TB-500 component is actually TB4, both it and the BPC version clear quickly. Best judgment should be used since it concerns one's own health, but pushing right up to the procedure does not seem worth it. Any current protocol will not lose much progress by staying cautious and restarting only after the operation.

CopperAlder51archiveJan 24

Most peptides do not have especially long half-lives. The longest among the GLP-1 examples are around six to seven days. Within the blend being considered, the BPC component has the longest at roughly three hours and the others are even shorter. A window of three to five days would probably be sufficient.

WarmQuill37archiveJan 24
↳ replying to @AmberCompass48 (opening post)

A similar medical appointment is coming up in April and the instruction was to stop the GLP-1 two weeks beforehand. Everything else will be paused at the same point just to stay on the safe side. Those two weeks will be spent repeating the earlier pre-op liquid diet to keep weight loss from stalling. It is not enjoyable but manageable, consisting mainly of protein shakes.

AmberCompass48archiveJan 25

Only the legal compounded version of the GLP-1 will be mentioned to the doctor. All injections will stop until the day of surgery, which is sixteen days away, and that should be enough. The gallbladder surgeon indicated two weeks to a month is typical for GLP-1s, and a similar discussion elsewhere mentioned someone who continued without interruption through their procedure. An eighteen-day gap from the last injection feels acceptable. The goal is to avoid complications such as aspirating material into the lungs.

AmberCompass48archiveJan 25
↳ replying to @WarmQuill37

That sounds like a good method for maintaining weight loss. It makes sense, especially with no prior surgical experience and after hearing the surgeon list many unpleasant possibilities. After thinking it over, every instruction from the medical team will be followed to help ensure the outcome is successful.

NorthThistle70archiveJan 25
↳ replying to @AmberCompass48

That reaction is understandable. Both knees were replaced a couple of years ago, and having a family member on a transplant team shows how important it is to follow the given directions.

AmberAlder58archiveJan 26

Lumbar surgery is scheduled for the tenth of February. During a pre-admission call the nurse was told about the GLP-1 and said it was fine to continue. This came from a private provider in the UK, so guidance may differ elsewhere, and no advice is being offered here. It was simply what was stated recently.

SlowLantern99archiveJan 26
↳ replying to @AmberAlder58

If anesthesia will be involved, that information appears incorrect and the surgeon or anesthesiologist should be contacted right away. GLP-1 medications slow digestion, which is why patients are told to fast before procedures to prevent anything remaining that could be aspirated. Everyone known to have had sedation-requiring surgery was instructed to stop at least two weeks prior. Extra caution may be involved, but it is preferable to the alternative risk.

AmberAlder58archiveJan 26
↳ replying to @SlowLantern99

The response was also surprising and the topic was going to be raised anyway. The nurse indicated that updated guidance no longer requires stopping. Medical advice will still be followed exactly rather than taking chances. Quick research suggests new recommendations from 2025 state these medications can be continued provided the team knows and can manage any risks. Statements from relevant professional bodies appear to support that position while emphasizing awareness. Previous instructions to stop may have been common, yet the current medical team's direction will be the one followed as it aligns with the latest information. No one should ever disregard advice given to them personally.

IronBramble31archiveJan 26

Hernia repair is upcoming and everything was stopped three weeks ago, which has been difficult. This will be the third operation while using a GLP-1. Each prior time the instruction was two weeks, but three weeks are used as extra precaution with both the GLP-1 and the other peptides.

LevelLedger10archiveJan 30

Even though the protocol has already been paused, recent information turned up that may be useful to know.

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