Decided to split dose. What's your experience been?

I split specifically to avoid the headaches I would get the day after injecting. You can use the GLP1 plotter to enter doses and see how concentration builds and how the max-to-min difference compares with once-weekly. Splitting lowers the peak a bit but raises the minimum a lot so I do not get food noise returning unless I need to increase the dose.

There are several things to understand about splitting. The graph shows the total amount possible in blood is lower which can reduce side effects. The baseline at steady state is also higher so the pulse is reduced as if you were keeping your finger on the doorbell. Some posts from people whose effects faded after a few months were often splitters. You can round to 4 mg if it makes vial math easier. It does not need to be that precise because receptor affinities and half-lives vary between people.

I split because a full weekly dose gives me really bad nausea that makes it hard to function. I dose about every 3.5 days and have had no side effects since. It has been a game changer.

The main gain I've seen is feeling much less worn out. I keep doses three and a half days apart, for instance from Sunday morning until Wednesday evening.

I was splitting into three doses for about the first year on Tirz. I started changing it the last few months to work in other things as needed.

I inject 4 milligrams each Friday morning along with 3.5 milligrams every Monday morning. Nothing major shows up as unwanted effects. A little burping shows up plus a mild warm sensation in my head the next day after dosing. That tells me the amount feels right for me. The Friday shot carries me across the weekend with hardly any thoughts about eating. The Monday shot keeps things steady the rest of the week. It has held up fine until now.

Just a quick update. I did my first split. Took 3.75 mg Sunday evening the 20th and again 3.75 mg Wednesday evening the 24th. Side effects are down massively. Did not get the usual headaches from 7.5 mg and much less fatigue. Tinnitus was not as bad either. Hunger suppression seems similar or better. Normally by day four or five I am trying to binge again but I will know more after a few more doses. Overall very happy though. Thank you to everyone who gave advice.