The original poster links two recent vomiting incidents to slowed digestion from retatrutide and especially cagrilintide after a recent dose increase, noting larger or later meals as triggers despite consistent diet. Others describe similar GI effects that often ease after a few weeks or with dose reduction, and some report relief from adding BPC-157 or KPV. Several users advise lowering or dropping cagrilintide rather than raising retatrutide, while emphasizing smaller portions and timing adjustments. Nausea and vomiting rates are noted as high with both compounds but frequently improve over time.
What this discussion establishesWhether to add cagrilintide or simply increase the retatrutide dose instead
Still openIdeal long-term dosing balance for minimal side effects while maintaining appetite control
Nothing here is advice.
I've lived fifty-five years and only thrown up maybe ten times total, most of those from drinking too much when I was younger. Vomiting almost never happens to me, yet it occurred twice this week. I think it ties to slowed digestion from the peptides, especially RETA and Cagri. The food was nothing unusual and my family ate the exact same things. I just had dinner a little later and a slightly bigger serving than normal. This seems like something that can happen with peptides that delay digestion. Wondering if anyone else has dealt with it. I'm on week 14 of reta at 2.5 mg twice a week, added cagri at 0.5 mg twice a week recently, and also take klow AD5 mots and tesa.
I vomited during my first week on tirz at 2.5 mg since I'm sensitive to meds, plus bad hiccups and acid reflux that lasted two or three weeks mostly at night. I used Tums often for that. After four weeks I moved to 5 mg and then 7.5 mg after twelve weeks with no stomach trouble now. The body seems to adjust, and I also started BPC-157 and KPV which I believe helped the digestion issues. Either way the symptoms improved fairly fast. GL!
It's probably the Cagri. When I tried it at 0.5 mg, eating even a little extra made me need to lie down right away from nausea. If you don't like how strongly it cuts appetite, stop the Cagri and raise the Reta dose instead.
I've had severe nausea twice since starting reta. The first came two days after the initial 2 mg dose. I felt fine the next day so I had beers and leftovers before bed, then woke up hours later with intense nausea like a childhood stomach virus. I didn't vomit but felt wrecked the following day. The second time happened on a dose increase week with a new vial from another source. Right after lying down I had to get up for the bathroom and nausea hit again. Still no vomiting but I felt awful for a while. I just have to be careful with dosing when starting new vials.
How did you manage to eat more on Reta? I basically have to force myself to eat at all.
I think you're correct. Cagri is the newest thing in my stack and I had just increased from 0.25 mg to 0.5 mg. I'm going to drop back to 0.2 mg and see what happens.
It's odd with Reta. I'm never hungry until I begin eating, then suddenly I feel hungry and could eat a lot. I usually don't because I know better, but this week I had a bit more than usual and both times my GI tract reacted hard. I woke at 3 am bloated, gassy, and very uncomfortable, and the burping had a bad taste that told me vomiting was coming. A couple hours later it happened and I was two pounds lighter.
Reta gave me huge hunger instead of nausea. It made me want to eat a lot and boosted my energy. I've never tried Cag and never vomited on a GLP. I'd suggest dropping Cag entirely since people report GI problems with it. Also time your Reta shots around when you plan bigger meals. I can usually handle large meals around day four onward without issues. What exactly did you mean by eating a little more than usual? Did it feel comfortable or did your stomach feel tight or nauseous?
I never got sick enough to vomit but occasionally felt very nauseous or had an all-day potty day. I'm on a similar stack.
These are relative amounts. I used to eat two full plates which was 1.3 to 1.5 times the right portion. Now I usually eat half to seven-tenths of a plate for dinner. On the nights I vomited I had a full plate or slightly more, right after going up to 0.5 mg cag. I'm now pretty sure Cagri caused it. At 0.25 mg I don't remember any problems, so I'll skip the next shot then drop to 0.2 mg and reassess.
I never pay attention to what those sorts say. They act just like the old harsh one. That was prior to your arrival I'm positive.
Hard to say without knowing the exact foods. You could try very basic meals like chicken soup with only carrots and potato or a small plate of plain eggs and oatmeal without milk, then slowly add things back. Or just stop the injections for one or two weeks and see if things normalize. Maybe try KPV to help the gut too.
I've kept the same eating pattern for a long while now, and my gut has handled food the same way the whole time. Coffee with milk starts the day, then protein drinks come in later before lunch and again midafternoon, with a green bowl sometimes added in. Kimchi usually goes with the main dishes along with a serving of meat or fish, one or two eggs cooked soft, and just a little plain rice. Daily intake sits between seventeen hundred and two thousand calories while my height is six foot five and weight has dropped to two hundred sixty five from three hundred one earlier. Strength sessions happen every day plus outdoor movement three or four times weekly, so energy burned exceeds what goes in. Slow processing always showed up with the earlier compound, yet this one can bring things to a complete stop once the amount rises. It packs a punch but proves worthwhile when the effects stay manageable.
Reta plus cagri slow gastric emptying and appetite, so things like latte or dairy, repeated protein shakes, kimchi or fermentation, salad fiber, eggs or fat, and rice volume can stay in the stomach longer and cause gas or nausea. You might try cutting shakes to one per day, switching to lactose-free, pausing kimchi and salad for now, eating smaller meals, lowering fat, and staying hydrated with electrolytes.
Did the group start treating Smiter like some kind of descriptive word?
At a wedding a few weeks ago I stopped for fast food on the way home and got instant heartburn, then hiccuped for three hours before vomiting it all up. I only had three drinks over seven hours.
Fourteen weeks ago with zero sides except the clear lack of hunger.
I sip the protein shake a few times and barely finish half of it. Portions are very small.
Both reta and cagri show fairly high rates of nausea and vomiting, with around half of people experiencing some degree of it. The only study combining cagri with something else was cagrisema and it also had high nausea and vomiting rates. Raising reta doses could contribute but adding cagri on top is even more likely the cause. What you're seeing is on the mild side of the spectrum. If adjusting meals by eating less at once and limiting drinks with food doesn't fix it, you may need to lower doses temporarily, though this side effect usually improves gradually. I'm curious why you added cagri at such a low reta dose instead of just increasing reta.
I didn't realize my reta dose at fourteen weeks was considered low. I keep seeing people at three times my dose and I'd rather keep all amounts as low as possible. Cagri looked like a good addition because the doses are small compared to reta. I think I almost had the balance right except I increased too quickly from lack of knowledge. The same stack at 0.25 mg cagri worked well. I had no idea another 0.25 mg would hit so hard, especially since I use many peptides daily or weekly with no sides until this. It makes sense that dropping to 0.2 mg cagri should bring me back to feeling fine, then I can watch how hunger responds.
I got some Cagril just to keep on hand. A 10 mg vial seemed like a lot for the doses I'd use but it can stay in the toolbox until it might help with a plateau or something. I agree that 250 mcg may be too much.
With every other peptide I've used, going a bit over or under isn't a big issue. Cag on the other hand is serious and can ruin a couple days with its harsh effects. Too much of the others like klow bpc, AD5, Mots, kpv, kp, or dsip causes no real problem.
I was just wondering why combine them instead of raising reta. There are good theoretical reasons for pairing fairly low doses of reta or tirz with cagri or elora since it might give the best weight loss with the fewest sides. Data shows reta 1 mg gives 9 percent loss and elora 1 mg also 9 percent, while reta 4 mg gives 19 percent and elora 3 mg gives 13 percent. If those effects add up it could be strong. I'm on cagri 0.25 mg every four days with tirz 15 and reta 5 mg, and any higher cagri dose clearly increases nausea. I couldn't locate the full cagri studies, only abstracts, when checking side effect rates.
Curious how you apply those two compounds when handling gut troubles. Could you mention the quantities that work for you?
I judge my GLP1 dose by nausea level. Slight nausea after two or three days means the dose is right. No nausea means too low. Strong nausea means too high. Nausea works well as a reminder not to eat.
That matches my year on ozempic where I ended up at 0.22 mg every other day because it cut hunger a little without too much nausea. Other GLP drugs have worked better for me with less nausea. The basic idea is correct for finding the right dose, but ideally you'd back it off ten percent to keep most appetite control while reducing nausea, or switch to twice-weekly dosing.
That's how my tirz dosing works. On the second or third day after the shot I get some burping and feel a little urpy at night. One or two Tums and I can sleep again knowing the dose is good. Food noise during the day stays at a low level. Hunger is present but not intense, and eating a few baby carrots or a handful of nuts leaves me satisfied. I pin Friday and Monday. The Friday shot covers the weekend with little interest in food, and the Monday shot overlaps to carry through the week. Then repeat.
If you have tried it, this topic is still open. Sign in to reply — it takes a minute.