Courtesy of the Downsized series I've been following for a while, here's a straightforward rundown on where the newest fifteen obesity drug candidates stand. I've already noticed several of them floating around and thought the list might be handy for others to review and watch for.
15 New Obesity Drugs Are Coming
Summary
What new obesity drugs and weight loss peptides are in development and how are people using current ones?
Users share reactions to a list of upcoming obesity treatments from a video series, discuss personal stacks of existing peptides for appetite control and maintenance, note excitement for new mechanisms, and joke about the decline of body positivity messaging as effective drugs spread.
What this discussion establishes- Combinations like reta plus cagri are praised for stronger satiety and slower digestion than single agents.
- Many report stockpiling current peptides for long-term maintenance rather than switching.
- Amylin analogs and other non-GLP pathways are seen as promising stack options with fewer GI issues.
- Some users view the flood of new drugs as making further purchases unnecessary once current supplies run out.
- Body-positivity topics surface with mixed feelings about changing cultural messages around size.
Whether new drugs will prompt users to abandon their current peptide routines or hoards.
Nothing here is advice.
31 replies · 22 people
It's wild how many weight-loss compounds are in the pipeline. At this stage none of it changes what I'm doing because the maintenance dose of reta and cagri I'm on already crushes hunger and gives me all the appetite control and fat loss I need. Still, it's interesting to hear what's coming and maybe in five or ten years something even stronger will appear.
Someone who writes about GLP drugs is attending the ADA conference this week and plans to post updates from the sessions. Given his focus on the area he'll probably cover many of these new candidates.
That's exactly why I stopped buying more tirz than I already have on hand. By the time I finish what I've got we'll all have moved on to whatever comes next.
↳ replying to @KeenPebble65
The Incretin Space blog that pulls together data on new incretin drugs and future directions looks useful. I've subscribed.
The real next step would be something that permanently targets white fat cells the way FTTP does but with a better safety profile, then stack it with a GLP-1. I've dropped a lot of weight on tirze and reta but expect I'll still need periodic use to hold the results.
↳ replying to @SlowLantern29
He mentioned starting retatrutide back in September 2023, almost a thousand days ago. There should be more updates from the conference on his blog and I'm also following his Bluesky posts about it.
↳ replying to @BlueKettle52
What does the cagri add for you that reta alone doesn't cover?
Forget the weight-loss stuff, when are we getting a peptide cure for male-pattern baldness?
↳ replying to @BlueKettle52
Same here. I'm in maintenance with a solid stash of peptide mixes that suit me. Anything new would have to be a outright cure, not just another ongoing treatment, before I'd switch. Back when I started I never pictured using research peptides, but after seeing how the big-pharma options were priced I don't see myself going back to those single-compound prescriptions.
↳ replying to @SharpHarbour71
I add 1.25 of cagri to 10 mg tirz and it gives an extra layer of fullness at dinner.
How many of the people who claim to be against big pharma will still end up using research-grade versions of these same meds?
I tried to join a local weight-loss study a few months ago that was testing THCV alongside a GLP-1 to reduce cravings, but I didn't meet the weight requirement. I still bought some of the compound online and the effect feels pretty mild, maybe the dose is too low.
↳ replying to @PatientTimber45
More like a campaign aimed at non-draftable fighting-age men and women of childbearing age. Obesity blocks both groups, so quietly allowing smaller people while cracking down on anyone who gets too large looks like a way to keep things stable.
Half those names have already been talked about here. I'm holding out for unicornitide, or maybe the sparkly version.
↳ replying to @LevelWillow54
I didn't actually need cagri because reta already handled everything, but I tried it anyway. Appetite and food noise stayed the same as before, completely gone, yet gastric emptying slowed even more. Food sits in the stomach longer and bowel movements become very sluggish. Five or six bites and I'm full, which helps cut calories but also leaves me low on energy later, so the combo is powerful for satiety yet comes with that digestive slowdown.
↳ replying to @SharpLantern71
Exactly. Once you've tried the gray-market options the legitimate versions look overpriced, and it pulls you into trying all sorts of other peptides. A lot of us now have years' worth of the weight-loss ones stocked, so any supply hiccup won't be an immediate problem.
I'm looking forward to trying the amylin analogs since they work differently from reta and should stack well.
Everyone pause for a moment of silence. Body positivity is about to end.
↳ replying to @NorthWillow72
Can she just disappear already?
↳ replying to @KeenKettle50
Only part of her will disappear; you'll have to wait until she raises her GLP-1 dose for the rest.
↳ replying to @NorthWillow72
I know nobody owes anyone a certain body type and I'm not shaming anyone for getting healthier, but it still feels a bit sad to lose heavy, sexy public figures and the idea that you can be attractive at any size. At the same time I'm on my way to staying in straight sizes without constant struggle and that feels good too. The social advantage of being thinner is hard to ignore even if I'm not chasing it.
↳ replying to @LevelAlder29
Well said. Everyone's path should be respected. From what I've seen of your posts I'm proud of the progress you've made.
I'm probably not a candidate for any brand-new wonder drug. I'm older and the stash of tirz and reta I already have will easily outlast my remaining years. I could log off the internet entirely and my routine would still be solid. It's impressive how quickly things are advancing though, and I hope it changes the world for the better.
↳ replying to @LevelAlder29
The news has been full of talk about body positivity fading because so many people are getting real results from treatments that work. The South Park reference was about the joke where the doctor prescribes listening to Lizzo instead of GLP-1s. I wasn't attacking her personally or her body. She has mentioned trying the drugs but feeling bad on them and using other methods, and she does look different now.
↳ replying to @NorthWillow72
I watched that South Park episode this morning after you mentioned it and it was spot-on and hilarious. I never got any sense you were attacking her anyway.
↳ replying to @NorthWillow72
My viewings of that animated series total just two, and each one turned out to be the installment featuring the recurring character's demise.
Can't wait for the next wave of peptides. Stanford used AI to find new targets and came up with a twelve-amino-acid peptide that acts right on the hypothalamus appetite center. BRP-3 works differently from GLP-1 so it avoids the GI side effects and muscle loss. It's a naturally occurring strong appetite suppressor discovered by their peptide predictor tool.
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