Giving up on Reta

You said 4 mg three times a week at only eight weeks in? Do you have any GLP-1 receptors left? That's like using dynamite to fish and then wondering why nothing is biting. Plus you're 6'3 at 200 pounds, rowing six nights a week, and eating like a small woman? Something doesn't add up. Are you serious?

Not arguing with what you went through, but if the calorie numbers are correct then your metabolism is an extreme outlier. Staying at 1500 calories with your size and activity level and seeing no loss points to a very low BMR. If it were me I'd get hormone and metabolic bloodwork done to check for anything fixable. What were you eating when you were losing on Sema? Are you type 2 diabetic on insulin? Still, there are definitely low responders to Reta and you might be one.

Doing 4 mg three times a week and feeling nothing is wild. I think the batch you had was bad. Switch your diet to low carb or keto, that helps a lot. With keto alone I dropped 18 kg in three months a couple years back before the big pandemic and never felt hungry. This time I needed help getting into ketosis so I started Mounjaro at 2.5 mg from my doctor and after three months I'm down about 20 kg. The first four weeks were rough with nausea and constipation. Change your diet. You can also add 5-HTP from Amazon to cut hunger and improve mood. Walk every day, start with 2-3 km relaxed. Throw out sugar and anything with more than one ingredient. Clean eating without sugar makes a huge difference. I still drink daily but it still works. Basically you need to shift your mindset. The drugs

Are you having tests done on your peps?

At 6'3 and 201 pounds with that activity level and 1500 calories, you should already be losing weight with or without Reta. If you're not then something metabolic is off. Get your hormones checked and see a doctor.

Maybe a dumb idea, but how sure are you about your reconstitution? Your results would make sense if you were actually taking 1.2 mg a week instead of 12 mg for example.

It seems like your weight is perfect for sports performance, and competitors enjoy using that medication. I don't understand why it hasn't kicked in fully after eight weeks, especially since you're also restricting calories. That drug hasn't impressed me much either. Adding it to the other one only brought me six more pounds of reduction, and that happened twelve months back. I increased my aerobic activity slightly and did some round-robin workouts at the facility five days weekly, but saw zero change. I stopped drinking from Monday through Friday after having several each evening before, yet nothing happened. Out of irritation I took a larger dose of one shortly after the other and dropped two pounds following seven weeks with no movement. In my case it appears nothing continues to function beyond a year and a half, so my system refuses to be tricked once more, like in that old comedy film.

1 mg of Sema works for you but 12 mg of Reta does nothing. That makes no sense at all. Test your stuff, check reconstitution, and let us know.

You got bad Reta, that's why. You're also probably under-counting calories badly. Weigh everything on a good scale including sauces and condiments. Skip the AI calorie estimators, they aren't accurate. Use the labels instead.

All Reta did for me was cause the worst constipation I've had in years. Honestly I didn't give it a real try since I was stacking it. I liked how Sema felt and it worked well stacked with Tirzepatide. Why not just stay on Sema?

LOL, would you say the same thing about gyms? It would be like: I got my bench up to a certain weight at gym A. Switched to gym B for a month and still can't bench more. Gym B sucks.

Even if the Reta was bad, with the workout routine and 1500 calories daily you should still be losing weight with or without any meds. The chance of having a metabolic condition that lets you train hard and hold weight on 1500 calories is way lower than overestimating exercise or underestimating food intake.

Thanks to everyone who gave real thoughts. The flood of dumb comments isn't helpful. I don't understand it either and that's why I asked. If I wanted smartass replies I could just watch the news you miserable twats.

Maybe take a couple months off and let your system clear. 12 mg of Reta with no weight loss after eight weeks seems extreme. I reached 12 mg once a week following the trial schedule and stopped losing. Sema did nothing for me two years earlier at the full dose. I've since dropped Reta to 6 mg and added some Cagri and I'm losing slowly now, which is fine as long as I don't regain.

Perhaps the items you received weren't up to par?

Sema is stronger because it only targets GLP while the others don't give the same hunger suppression.

There was a recent study suggesting people who respond well to Tirzepatide differ from those who respond well to Semaglutide. Patients with low baseline GLP-1 levels responded strongly to Sema while those with low baseline GIP responded well to Tirz. People with both only did well on Tirz. Reta is probably similar and closer to Tirzepatide. If that's accurate you might be in the area where strong Sema responders do poorly on Tirz and maybe Reta too. I've started suggesting that people struggling on Tirz or Reta try Sema instead.

I was thinking of mentioning how that research applies here. Around five to ten percent of individuals see almost no reduction from these medications. Assuming your version works fine, perhaps you're among the few who don't get much effect, and similar results might occur with alternatives too, though semaglutide worked for you earlier. The research points to responding mostly through one pathway rather than the others, making semaglutide potentially preferable over tirzepatide in such cases, even if the latter usually outperforms for everyone else. It's tough to square the lack of progress given your current size, activity level, and intake. Major prior loss or extended restriction would explain adaptation better. The straightforward reason is that tracking intake often misses the mark for most, which isn't a judgment but common. Double-checking measurements and logging everything could reveal discrepancies. Diabetes might slow things slightly, yet some drop should still happen under those conditions. Low daily burn seems unlikely too. We don't know much yet about whether non-responders improve with amylin types, though future data could clarify, so that option could be one to look at.

Sorry Reta isn't working for you. Since you feel Tirz right away, any reason not to stick with that? With your calories and activity the lack of loss could point to a metabolic disorder. A nutritionist can test metabolism with an indirect calorimeter and bloodwork can fill in the rest. It's possible you're describing intake and exercise accurately but have a condition that makes loss very hard. There have been studies where different racial groups followed the same diet and some lost less due to genetic factors from ancestral survival traits. Metabolisms are strange.

Your TDEE is around 2800 calories a day. At 1500 calories daily even without Reta you should be dropping a lot of weight every week. If you can't track calories accurately are you sure you're reconstituting Reta correctly? At least read the basic guides and tutorials first.

Let's be realistic. You're probably not tracking calories correctly or your dose. I doubt you're actually taking 12 mg a week but even if you are you're definitely not in a calorie deficit and your counting is off. It's true your metabolism could be very slow and burn fewer calories but that also means less body function overall. It's like running a car in eco mode. Energy would be low, brain fog would be bad, and you'd be sleepy all day. You would know your body is in eco mode and wouldn't be rowing multiple times a week.

Why do people expect this to make them lose 100 pounds in a month? You went up too fast. I started at 1 mg then moved to 2 mg the second month. So far 25 pounds lost in two months. People need more patience with these things.

This was an interesting read and OP I didn't see any smartass comments. I read a lot of confused people questioning how you're defying thermodynamics. People want to help but you have to answer the key questions: are you tracking calories meticulously and correctly, and have you reconstituted your Reta correctly? The second question matters less if the first isn't solid, but both are worth checking.

Someone insisting they consume just fifteen hundred calories daily while rowing on most days should drop pounds whether using that medication or any comparable ones. I think confirming intake by weighing portions accurately would clear things up. Biology makes it impossible for a two hundred pound person to hold steady on that amount or below.

Sounds like a product quality issue. I agree with the others, get bloodwork done. I'm big on all of us peptide users checking bloods at least yearly.

It's surprising how many here jumped straight to labeling someone as foolish. From discussions I've followed lately, some folks show little reaction to certain options. One didn't deliver the same results for me as the other, which led me to switch back. Lots of others mention the cravings returning with that choice. It might help to look into whatever else someone is using or whether recent tests were done. Keeping track of intake is basic enough that it's odd to question it repeatedly. Better to give people the benefit of the doubt instead of dismissing them right away. These spots are meant for supporting each other. Now the individual might head off elsewhere, and learning the real details could have mattered. Yet the response has been insults plus claims that it can't occur. Nice work everyone.

Like I noted earlier, a tall guy around two hundred pounds who hits the gym often is probably miscounting what he eats rather than requiring an unusually low amount under fifteen hundred calories. This comes from someone who is forty six, going through perimenopause, gets moderate exercise, and maintains on about sixteen hundred.

This is not adding up. 12 mg a week 4 mg split dose, never heard of a three times split dose. Whatever you're putting in your body is not Reta.

If you know you know.