Reta making me extremely hungry

I get that. While off tirzepatide for nearly two months I felt normal, but now hunger is actually higher than before any GLP medication. The mixing looks strange because I bought a 40 mg vial by accident. To avoid waste I reconstituted and used only half of it, 20 mg, and froze the rest for later.

The pen cartridge I have only holds 3 ml total.

Out of interest, do you think the reconstituted reta lost potency after time in the freezer?

I went from 105 kg down to an unhealthy 78 kg, then after Christmas and a Japan trip I was back to 85 kg. No sides at all on either drug. Body fat fell from 32 % to 18 %. Goal is under 15 %. I switched because Mounjaro was too expensive. I swim and lift four times a week plus tennis and cycling. I plan to go up to 4 mg.

I am not using the frozen portion, only the other half.

Okay. I hoped the third pathway would make a big difference. I will keep going for a while. Part of me wonders if the batch is weak, since even 1 mg of Mounjaro gave me noticeable effects.

That makes sense. Research says reconstituted peptide does not hold up well after freezing, though some users report only slight loss. My own test subject will show results in a few months and I will post separately then.

From what I have read the glucagon receptor does not really engage until above 6 mg, though some feel effects sooner. I am only at 3 mg this month and will move to 4 mg next month.

That is a long wait if you follow the usual schedule. I plan to reach 4 mg by week three. I suspect prior tirzepatide use may have built some tolerance, but time will tell.

Do not freeze reconstituted retatrutide. Use the whole vial; degradation is minimal even at 60 days. Filtering is wise because bacterial growth becomes the main concern after four weeks.

It takes a full month for steady-state levels. Increasing every three weeks means you never reach full effect. Dosing by feel is risky. Give each dose time.

Do you think my body is already adapted to GLP drugs from Mounjaro?

That does not change how these drugs behave. It is not about getting used to GLP drugs; the pharmacokinetics are the same for everyone.

I understand the standard timeline, but responses vary. Some notice effects at 0.5 mg while others need 8 mg and several months. I will update once I reach 4 mg.

You can reach higher accumulated levels faster than waiting four or five weeks at each step. I went from zero reta to over 9 mg peak in 18 days while still clearing tirzepatide, and I am now seven weeks in at 4 mg twice weekly.

Just because it is possible does not mean it is advisable. Some people do it, but that does not prove safety.

Too late, it is already frozen and thawed. I have added bac water and will dose my test subject next week to see what happens.

Thanks, that matches some of the advice I have seen. If my test subject survives I will report results over the coming weeks.

You have a talking rat?

Rats rarely get fat unless given a high-fat diet and limited space. I used to let mine run free in the evenings; they would come back when I shook a peanut bag. That was in the early 2000s so no photos, but my ex still recalls seven rats waiting in a circle for their bedtime peanut.