Those combining Reta and Tirz

When you moved from tirz to reta, did you begin reta at the same milligram amount you were using for tirz?

I agree, and it will also raise the chance of side effects.

That matches what I have been thinking, though some here have pushed back on the 4 mg threshold. I bought reta mainly for the glucagon fat-burning effect. I am close to goal but still carry a little belly that will not budge. Even after long hikes years ago that took me down to 170 lb there was still that apron of fat. I know reta is only part of the solution, but I will add resistance training and whatever else seems useful.

The video points out that the clinical trials support the 4 mg figure, so what is the issue?

I am convinced on the 4 mg point and want to reach it fairly quickly. I have room to lower the 10 mg tirz if reta sides stay manageable, so I can add reta on top of a reasonable tirz dose. I will split both and adjust from there. I have enough of each to last years whether I use one or both.

Over a thousand miles on the Appalachian Trail in one go? That is impressive. I hike regularly and my family is surprised when I do five-mile walks every other day. Your numbers would amaze them.

Arizona has many trails to explore and I've always enjoyed that kind of activity. During the nineties when I had greater stamina and nerve I would prepare over several weeks then attempt the big canyon crossing twice in one go. The path covers more than forty miles while climbing above twelve thousand feet total. I finished those journeys inside eleven hours while the sun was still up. I repeated similar long day outings often yet skipped any overnight gear carrying. Reaching fifty nine made me realize it was now or never before my health or physician stopped me entirely so I headed out for two and a half months of it.

Exactly. For me the stack has produced extra benefits. It can be useful to test things on yourself even when one approach does not pan out, since new options keep appearing.

Well done. I want to be like that when I am older.

The video does not load here, but the title is Stop Wasting Retatrutide! Heres the Sweet Spot (Weightloss Dr. Explains) by Dr. Kevin Joseph.

That is inspiring. I have only done day hikes in the Appalachians and prefer a bit more comfort, but I respect the determination.

Did your doctor suggest sticking to shorter local trails instead?

Squaw Peak is where I trained for the canyon hikes. I would work up over months and do multiple laps most days, totaling about 22 ascents and descents per week with 1,200 feet of gain each time.

This does not match how drugs work. Receptor response to an agonist follows a stretched S-shaped curve. Retatrutide data show clear weight-loss effects at 1 mg (about 9 percent over a year), stronger at 4 mg (18 percent), and still more at 12 mg (29 percent). That places 4 mg well into the rising part of the curve, not at the start, so there is no special threshold where glucagon agonism suddenly begins. The claim is inconsistent with basic pharmacology and the actual trial numbers. The doctor in the video may have credentials, but the statement is incorrect and also conflicts with research favoring higher rather than very low doses.

That is just your opinion and it means nothing. I see you are back after the ban.

They need a pffffft emoji.

There it is, just needs to be small enough to carry.

And there it is, just needs to be shrunk down and pocket sized.