CommunityDosing & Titration

Not Good - Gaining on 15 mg Tirz

56 replies31 peopleAug 11, 2026☆ Follow
Summary

why am I regaining weight on max dose tirzepatide after hitting goal and what options help stop it

The original poster reached goal on 15 mg tirzepatide weekly but has regained about 10 lb over six months with returning food noise. Participants suggest changing injection frequency, stacking another peptide, adjusting calories or training, or checking batch quality. Many report similar stalls or slow regain once at goal and note that maintenance lacks strong clinical data so people experiment. Several emphasize that lower calories or more movement are still required even on these drugs.

What this discussion establishesWhere people disagree

whether the regain is mainly from tolerance to the drug, unnoticed calorie creep, or metabolic adaptation

Still open

which stacking order or dose adjustment works best long term for maintenance

Nothing here is advice.

56 replies · 31 people · page 1 of 2
PlainTimber88archiveopening postAug 11

I have tried every diet and even had gastric bypass surgery, yet tirzepatide finally produced real weight loss for me. Over the past six months though my weight has crept up about ten pounds even though my exercise and calories stayed the same. Food noise seems to be creeping back as well. I am still using fifteen milligrams once a week and have asked before about adding reta or cagri but would like fresh opinions on what has actually worked for others or whether sema would be better. I am taking steps on this today because I do not want to slide back.

GreyHarbour88archiveAug 11

Did you reach your goal weight before the gain started? Quite a few here go above fifteen milligrams. I hit a stall short of goal on tirz so I gradually added reta and reduced the tirz over roughly two months and that got me past the plateau.

PlainTimber88archiveAug 11

I went below goal without much mental struggle and actually ended up too lean, which made me look older. The recent gain caught me by surprise until the love handles returned and that finally prompted action.

AmberCinder18archiveAug 11

I am in a similar spot with very slow loss the last few months. Two weeks ago I moved to fifteen milligrams hoping for more effect but saw nothing. Last week I dropped back to twelve point five and switched to every five days instead of six. The total weekly amount stayed roughly the same yet I started dropping weight daily, three pounds in three days. I also added electrolytes at the same time so I cannot be sure what caused it, but it is worth noting.

WarmMeadow92archiveAug 11
↳ replying to @PlainTimber88 (opening post)

I also had bypass surgery years ago and tirzepatide worked well for me too. I am currently at seventeen milligrams after previously using twenty. I am now stacking with another compound after earlier brief stacks with sema and cagri. Since you already hit goal this looks more like a maintenance problem. There is little solid research on maintenance so most people try different combinations. I would try adding a small amount of sema or cagri rather than going higher on tirz because higher doses seem to bring more side effects without proportional benefit.

GreyFenwick31archiveAug 11
↳ replying to @PlainTimber88 (opening post)

Sorry you are dealing with this regain. Six months is long enough for the pounds to add up without noticing at first. After major loss the body seems to have a memory for fat and can regain quickly with small slips. Adding reta might help raise metabolic rate. Stress, cortisol, or sleep changes could also play a role. If acting today I would try a week of very clean eating plus reta to see if it shifts things. Do not beat yourself up, you are already taking steps to correct it.

WarmSparrow60archiveAug 11

You have several routes. Higher tirz doses up to twenty or twenty five milligrams are being studied. Adding a low dose of another compound around one to two milligrams is an option. Mitochondrial support peptides or secretagogues could be tried. Some add growth hormone. More weight lifting three times a week plus fasted cardio may help. Diet fine tuning or adding specific amino compounds are other possibilities. The next two items may cause temporary water retention.

WarmMeadow92archiveAug 11
↳ replying to @WarmSparrow60

That list is helpful. On the stacking suggestion I would still try cagri first for many people because it has a longer track record, lower cost, and easier testing. I stopped using it only because of fatigue. Current supply issues with the other option make cagri worth testing first unless the person is fine with the variable quality available right now.

BrightSparrow36archiveAug 11

Your calorie needs are lower now so the same intake that once maintained weight now produces gain. You will need to lower calories further or increase workouts without adding food.

WarmSparrow60archiveAug 11
↳ replying to @WarmMeadow92

I was thinking of your experience with cagri when I listed it. Fatigue would not fit my schedule so that is why I never tried it earlier.

SharpAnchor92archiveAug 11

Did you switch to a new batch of tirz right around the time the gain began?

WarmMeadow92archiveAug 11
↳ replying to @WarmSparrow60

I did complain a lot about the fatigue from cagri. Good quality of the other option is probably preferable but the current market has many untested products. Some tested vials came back far under labeled strength. Pricing on the tested source is acceptable and I might have skipped cagri if I had known it was becoming available sooner.

CopperQuill49archiveAug 11
↳ replying to @SharpAnchor92

That batch question would be my first one too. I have held roughly the same weight for almost a year but it is still thirteen pounds above my lowest. That appears to be my no effort zone. I am slowly adding reta to my tirz and just obtained some of the other compound. I am restarting more deliberate effort. Dose level of tirz does not seem to change how I feel whether at twenty, fifteen, or twelve point five.

GreyAlder96archiveAug 11

Hate to ask but are you certain calories have not changed? It is uncommon to gain on the same intake. Tirz mainly works through appetite control rather than burning calories. In maintenance it is easy for one or two extra items to add up. First step I would try is keeping the same dose but injecting every five or six days since hunger often returns before the next weekly shot.

PlainAlder11archiveAug 11

Off topic but the original poster lives in one of my favorite places to visit. My wife and I usually go once a year and enjoy the drive depending on traffic and season.

WarmSparrow60archiveAug 11
↳ replying to @SharpAnchor92

Completely agree on the batch point. I keep stock from multiple sources so the better ones rise to the top. Between compounded and other sources I have about eleven different versions. Most work well and a few do not so those go to the bottom of storage and are unlikely to be used again. Single vials are my main weakness while kits tend to be reliable.

ClearBramble68archiveAug 11

With food noise returning but no major crisis you still have several choices. Changing to fifteen milligrams every five days instead of seven is one of the simpler first steps. It raises the weekly total modestly and may reduce hunger on the later days of the cycle.

LevelThistle44archiveAug 11
↳ replying to @GreyAlder96

No need to apologize, that is almost certainly the issue. Either more calories in or fewer out. The solution is to eat less or move more. Using more medicine, more tracking, or both can help reduce intake. Switching to every five days would raise the effective weekly dose by about forty percent from fifteen to twenty one milligrams.

SlowLedger42archiveAug 11

I appreciate that you recognize a stall is normal while actual regain signals something needs adjustment. The advice already given covers the practical steps so I will not repeat it. One extra thought is to view weight maintenance as a tug of war with many factors pulling on each side. Even while using a GLP you can still layer in other dietary approaches that worked for you before.

ClearBramble68archiveAug 11
↳ replying to @LevelThistle44

Forty percent is not huge. Ongoing higher dose trials and the approval of higher sema doses suggest this change would be reasonable to test and monitor for side effects.

IronMarble78archiveAug 11

Your body has adapted and now has a lower metabolic rate so you are eating more than needed. Calculate your current TDEE and then reduce below that to create loss.

LevelThistle44archiveAug 11
↳ replying to @ClearBramble68

The earlier step from twelve point five to fifteen was a twenty percent increase. Moving from seven day to five day pins would double that jump. I am not opposed to going past studied doses since I used eighteen to twenty milligrams of reta for months, but a forty percent increase does not seem like the most cautious first move for a slow ten pound regain over half a year.

WrySparrow92archiveAug 11

Sema is the only one of the three I have used that reliably stops food noise for me. I would start at point two five and adjust from there. I have cagri but never needed it once sema handled the noise. I began with Ozempic four years ago so it remains my go to.

PatientHarbour28archiveAug 11

This regain fear is common. That is why I keep stressing the importance of building new habits while the weight is still coming off. Those habits make maintenance easier later. The system is complex with nutrition, biology, microbiome, and old habits all interacting. In short, create new routines now or the old ones will return.

PlainTimber88archiveAug 11
↳ replying to @GreyFenwick31

Thanks for the supportive reply. It is messing with my head again, as if food alone was not enough. Good to know others understand.

LevelTimber64archiveAug 11

I stack tirz with survo on a six day schedule with a three day offset. It has worked well and preserves my tirz supply. I tried cagri once but felt very ill for twenty four hours afterward and could not bring myself to repeat it, especially during a vacation.

SlowLedger31archiveAug 11

Without a glucagon agonist these drugs do not directly burn calories. It still comes down to intake versus output. Even when I was cycling twenty four miles daily the weight did not move until I lowered food intake.

BlueTimber11archiveAug 11

You mentioned exercise stayed the same. How is the strength training portion? If it is mostly cardio the body becomes more efficient and burns fewer calories over time. Muscle loss during a deficit can also make weight creep possible even with unchanged diet and activity.

BrightSparrow36archiveAug 11

True, and after that point the rest is correct. You still have to eat below what your body needs to lose. I assume the point was that without a glucagon agonist to add some burn you have to reduce intake. The gif is always funny though.

NorthWillow72archiveAug 11
↳ replying to @BrightSparrow36

I did not get to my previous size by stopping when full. I ate for sport, past full until I was tired. Even on these medications I know I could still out eat them if I wanted, though it would hurt.

BrightSparrow36archiveAug 11
↳ replying to @NorthWillow72

Exactly. I still count calories daily even on the medications. The difference is I am not hungry while doing it. I have lost sixty five plus pounds in one hundred seventy seven days. I stay active but could still eat more if I chose.

SlowLedger31archiveAug 12

It stops hunger but does not burn calories on its own.

CopperSignal27archiveAug 12
↳ replying to @PlainTimber88 (opening post)

Sorry this is happening. It seems uncommon to see slow regain on the same high dose that got you to goal. Tolerance is one possible explanation though individual responses vary widely. Calorie counting may not be necessary if you did not use it to lose. Changing food types to more calorie dense options could allow more intake without extra hunger. Keeping weight off long term after the initial success is often the harder part.

LevelTimber64archiveAug 12

RNY means Roux en Y. Anyone can regain one hundred pounds one small bite at a time.

WarmAlder42archiveAug 12
↳ replying to @AmberCinder18

That schedule change is interesting. I am in the same situation with about ten pounds left and thirteen months of no movement. I tried adding reta earlier but could not tolerate the higher resting heart rate and poor sleep. I was considering fifteen milligrams every six days but the idea of trying twelve point five every five days sounds worth testing before moving to other compounds.

LevelSparrow20archiveAug 12
↳ replying to @PlainTimber88 (opening post)

I am also curious because I am at fifteen milligrams and feel the effects have faded. Not sure what to try next.

AmberCompass26archiveAug 14

Same experience here, down to two hundred ten then back to two hundred thirty while on max tirz. Considering fifteen plus milligrams of tirz with a small reta dose. Earlier solo reta worked but left me feeling very flat. So the plan would be low reta with high tirz as an experiment.

SlowAnchor19archiveAug 15

If it were purely calories in versus out I would be much leaner by now. These drugs help people with metabolic issues finally see results from consistent effort.

RustHarbour17archiveAug 15
↳ replying to @PlainTimber88 (opening post)

My own progress on sema has been slow but steady. My husband lost on Ozempic but became less careful with eating and regained. I do not micromanage him but I see what he eats. Sema has not been magic for me either. It still requires ongoing work and I still make mistakes.

LevelTimber64archiveAug 15
↳ replying to @SlowAnchor19

This. The conventional calories in calories out view is not the full picture.

NorthWillow72archiveAug 15

Without tirz I would still be overweight. Many diets never worked for me. Tirz finally quieted the constant food thoughts. All the studies still show calorie reduction as the common factor. If the scale is not moving you may want to check whether intake is higher than realized even without counting.

KeenKettle50archiveAug 15
↳ replying to @NorthWillow72

My fear is that without adding retatrutide all progress will be lost.

NorthWillow72archiveAug 15
↳ replying to @KeenKettle50

If I recall you are on TRT. When I started TRT I saw some weight gain from increased hunger and water. Once levels balanced and I added resistance work it came back down. I have no problem considering reta if tirz stops working or as a stack for the glucagon effect. The medication has worked reliably for almost two years. I weighed in at one hundred sixty four recently without counting calories, just focusing on protein and fiber.

IronKettle95archiveAug 15
↳ replying to @RustHarbour17

This part gets overlooked. These are not magic shots. Plenty of work goes into good results. I saw someone on another forum complain about eight months on tirz with no loss. That is hard to understand. I check my weight daily and adjust based on the previous day. My doctor never mentioned diet or exercise when prescribing. I know there are no magic fat burning pills.

NorthWillow72archiveAug 15
↳ replying to @IronKettle95

For me tirz felt miraculous. That is why I make sure I never run out. I still forced myself to get steps in even on tired days and cut most refined sugars and fats for the first seven months. Now I am more relaxed and tirz does most of the work. Different people respond differently. Some lose easily, others need the right combination. Reta adds a burning effect that can feel like extra help.

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