Reta plateau slow progress considering switch to tirz for appetite control

Have you tried GLP agonists before? The limited effect so far seems odd to me. What is your daily calorie consumption like? Overall weight management boils down to energy balance though this medication's action on the glucagon receptor could raise your burn rate by a couple hundred calories each day. Can you describe how you mixed the powder and calculated doses provided the vial amount is accurate? I've exceeded the amounts used in trials without using that other compound. I haven't noticed any adverse effects or issues.

I don't see much point in raising the amount just because the number on the scale has stayed put for a couple weeks. The level I'm already using with the two compounds together is already quite high, so I would check the usual everyday factors before considering any switch or bump. Dropping from 295 down near 278 still counts as decent movement, and a plateau after shedding close to twenty pounds is pretty common when workouts, fluid shifts, salt intake, carbohydrate levels, bowel habits, or swelling are all fluctuating. The daily calorie target might also feel stricter than it really is once you factor in how precisely everything gets logged, plus any differences on weekends, extra oils or condiments, occasional tastes, and whatever gets entered in the app. Hunger signals alone don't prove the medication has stopped doing its job either. At this body weight, doing brisk walks a few times a week plus three lifting sessions can make a very low intake feel rough and hard to keep up with over time. For now I would stay where I am, focus harder on consistent logging for a short period, track the average across the week rather than single days, confirm protein, fiber, and mineral intake are adequate, and try adding more walking before considering any adjustment. Should things stay flat after those steps, it might be time to check in with someone more seasoned or a medical professional. I haven't been on this compound long and came from the other one, where the reduction in appetite urges felt stronger, so I'm careful not to treat a higher amount as the automatic fix when the current level is already substantial.

My weight has come down nicely by 17 pounds from February at age 44 through regular lifts and brisk walks. That's handling the tough parts correctly. A flat stretch of roughly a month near 278 to 280 on that 12 mg combo with the added 0.75 amount shows up often during strength work. Fat loss with stable or added muscle might be underway, so the scale stays put. Checking tape measurements around the middle, progress pictures, or how outfits sit can reveal shifts the numbers miss. Sitting at 1950 calories yet still noticing hunger shows the metabolism adjusting on these compounds. Cutting straight to 1500 would feel rough and tough to keep up. Raising protein intake toward 180 grams or more, choosing bigger portions of lower calorie foods like greens plus fiber sources, or adding occasional higher intake days has worked for some instead of big cuts. The top trial amount sometimes stops progress for users. Holding steady often lets things move again after several weeks of routine. Adjusting the second part a bit has eased hunger signals more for certain people. Since pounds have already dropped and habits are set, this isn't slow response territory. Keeping detailed food records, staying hydrated, resting enough, and easing tension all help. Mixing walks with weights builds real results over months. Plenty of others move past these flat spots and drop further. What end weight are you shooting for?

Maybe all this effort means my muscles are growing instead so the number on the scale stays put. That counts as a positive change. Others already suggested holding at the current amount. I will keep my consumption level steady over the next few weeks while adding workouts and more protein. Plateaus hit everyone and count as a normal stage in the process. That dose already feels high so going higher would bring smaller gains until fresh information appears.

I found myself dealing with an identical issue even though folks say I look quite attractive. I tried combining those three compounds at fairly high levels yet felt nothing at all no burps or anything else. I kept suspecting my thyroid was off even after the doctor reviewed my labs and said everything checked out. Hours of digging online led me to try adding iodine so I began with a couple drops each morning mixed into coffee along with water and a little salt then increased to five. Suddenly the pounds started dropping the appetite control from the main compound improved noticeably my energy shot up old aches disappeared and mental clarity returned. It really transformed how I feel overall. I kept quiet about it until someone else brought up how thyroid function might influence the medication's effectiveness which lined up with what I had already noticed though several months later. This approach could make a difference for others too since results vary from person to person.

What is your exact macro?

I'm wondering about the meals others consume now. Before beginning a low carb diet with unprocessed ingredients, I craved sugary items such as baked goods and deep fried snacks because my brain got hooked on the reward chemicals. Feeling empty can help shed pounds, yet when meals trigger dependency in the mind, the urge might surface differently. That's why I avoid occasional indulgences while using this treatment.

How is your thyroid levels?

Haven't noticed any shifts yet while taking Reta. Here's the week by week record for me so far... Any thoughts on what's going on? Would really value some input or suggestions.
Week one 1mg held at 278lbs
Week two 2mg still 278lbs
Week three 2mg rose to 280.4lbs
Week four 2mg fell to 277.6lbs
Week five 3mg returned to 280lbs
Week six 3mg stayed put
Week seven 4mg no movement
Week eight 4mg unchanged
Week nine 6mg same weight
Week ten 6mg down to 278lbs
Week eleven 6mg reached 276.4lbs
Week twelve 8mg back at 278lbs

I believe the intake numbers are being underestimated. Ultimately weight loss boils down to basic arithmetic. Consuming fewer calories than expended leads to shedding pounds. The medication aids in reducing food intake and possibly elevates metabolism slightly at rest yet over time if the weight stays the same more energy is taken in than used up. Things like sauces nibbles or drinks might be the culprits but I feel certain some intake gets overlooked. Cutting down sharply to fifteen hundred seems too drastic and without maintaining it long term it risks a strong rebound effect. Instead from the current one thousand nine hundred fifty lowering to eighteen hundred or eighteen fifty while being precise and monitoring progress makes sense. Since one pound of fat equates to about thirty five hundred calories maintaining a five hundred calorie gap daily across a week results in losing that pound. Exceeding the limit even for a couple of days can negate the entire week's effort.

Wow, this community is really something special. Honestly. Feels good to have found a spot where I can chat about these topics.

It looks to me like folks treat the balance of energy consumed and expended as an infallible way to spot mistakes in how folks live their lives. Yet that view falls apart once you notice plenty of us turn to those specific medications anyway. Years lived really slow the rate at which the body uses fuel while resting. A steep drop in daily intake might lower that resting rate for good, the way it did for people on a televised slimming contest. The person who started this thread could easily have a resting burn rate sitting unusually low from time passed or from hidden issues. Perhaps the neck gland is involved, or excess cortisol is at play, or the system is simply settling into a new level after months of eating far less.

People keep bringing up how getting older supposedly makes your system burn energy slower and similar claims, but some extensive new research showed that's not really true until well past sixty. For lots of folks it's probably just a convenient reason to lean on.

18 pounds over three months, even counting the first few pounds of water weight, is underwhelming. A true stall this soon seems unlikely; fluid shifts are more probable, yet the overall pace on these doses plus the combo still looks weak and points to limited response. Actual plateaus usually show up closer to a year in. If the trend is something like four pounds a month and later picks up, it could just be a slow responder. You mentioned almost no sides. Without height it is hard to judge starting point, but heavier people usually drop faster. Prior diabetes also tends to blunt results. Trying a fresh batch might rule out a weak vial. Most likely the logged intake is a little high, since few people weigh every single item.

You are almost certainly eating more than the numbers show. That is the usual explanation in these cases. Even with tracking apps most people undercount what actually goes in. Switching to tirz or adding it on top could help. Lifting and walking are fine, but neither burns that many calories compared with running or cycling.

Study data on reta shows the benefit levels off around 8-9 mg. Going past that probably will not fix whatever else is blocking progress. I would look at other factors instead of pushing the dose higher.

Could it be a weak batch? The source is one people here rate highly and the tests look solid, yet I never tested my own vials. Earlier sema felt strong even though the scale did not move much. Thyroid checks are always fine and testosterone is good. Recent bloodwork was clean across the board. Maybe the recent stop of Lexapro is playing a role; past SSRI use added weight that came off when I quit. I am considering tirz from the same source for convenience and wondering what starting dose would make sense.

Have you run a full hormone and thyroid panel lately? Total and free testosterone, SHBG, estradiol, insulin resistance, IGF-1, CRP, ESR, TSH, free T4, free T3, and reverse T3 would all be useful. Starting at 12 mg with little effect makes me wonder if something else is going on.