Sema non-responders, have you had better luck with tirz or reta?

So far no studies address this situation at all. Going straight to reta makes sense because if GLP-1 alone does little, adding GIP and glucagon might change things, or trying an amylin drug like cagri could work through a different route. Variants in the GLP-1 receptor or its signaling pathways likely explain why some people get almost no weight loss. Odds of also responding poorly to tirz or reta are probably higher than normal, though still worth testing for a couple of months. I stayed on low-dose ozempic for a year with no scale movement, just constant tiredness and mild nausea, though appetite was somewhat lower.

Response can depend on several factors, including whether someone has type 2 diabetes or takes meds like gabapentin. Plenty of people moved from sema to tirz or reta and saw stronger effects. It seems worth testing one of those before giving up on the whole group of GLP drugs.

I stayed on sema nearly a full year. The first two months brought ten pounds off, then progress stopped completely. Appetite suppression stayed weak and I felt awful the whole time. Moving to reta changed everything.

I can share what happened in my case. After three months of sema titrated by my doctor I had some appetite drop but stayed fatigued and dropped no weight, so it was stopped. Starting the lowest dose of Mounjaro gave slight nausea yet some loss right away, probably water, plus much less interest in fried food and smaller portions. A week later I began reta, now at 2 mg after starting at 1 mg. Four weeks in the scale is down seven pounds while I also lift and use creatine plus whey. Face looks slimmer and shirts fit better even if changes are gradual.