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Starting Mito Stack tomorrow - Sanity Check

11 replies10 peopleAug 11, 2026☆ Follow
Summary

mitochondrial stack with NAD MOTS-c SS-31 on retatrutide experiences and timing

Users share personal results from similar mitochondrial protocols while on retatrutide. Some report better stamina during physical tasks after starting NAD+, while others note energy gains from SS-31. Concerns include possible allergic reactions to MOTS-c after breaks and questions around optimal dosing times. Nasal NAD delivery is mentioned but alternatives like oral precursors are suggested by one participant.

What this discussion establishesWhere people disagree

Optimal time of day for SS-31 administration

Still open

Whether the full stack outperforms NAD+ by itself and how nasal NAD compares to injections

Nothing here is advice.

11 replies · 10 people
WarmWillow50archiveopening postAug 11

I'm a 59-year-old male, five foot six, started at 181 pounds and now at 160. This is month three on retatrutide, currently 1-4 mg every sixth day. I've also been on the wolverine stack for three weeks. I have high blood pressure, borderline high cholesterol, elevated liver enzymes possibly from visceral fat, and ongoing fatigue. Sleep tracking looks decent except deep sleep is very low. Bloodwork was last done May 1 before the retatrutide, next set in November. Dexa scan coming up soon. Planning this stack and would appreciate any input. I'll take the NAD nasally to cut down on injections.

ClearLantern70archiveAug 11

That stack looks solid to me since I ran the same one. At 42 I'm younger so it might suit you even better. Try the MOTS-c and NAD first thing in the morning on an empty stomach before training, then have breakfast. Save the SS-31 for later in the evening well after dinner. Injections worked well for my NAD but I have no experience with the nasal route. Update us on how it turns out.

PlainCinder41archiveAug 11
↳ replying to @ClearLantern70

What is the reason for taking SS-31 at night? I'm still new to these compounds and have been considering a similar approach.

GreySparrow51archiveAug 11

Keep an epinephrine pen nearby because MOTS-c has triggered anaphylaxis in some cases. It went fine through nearly a whole kit for me, then after a pause the next try caused issues so I had to drop it. Best of luck.

ClearLantern70archiveAug 11
↳ replying to @PlainCinder41

I can't recall the exact reason I chose evening dosing. Checking some usual sources they tend to recommend morning instead. Evening has worked fine for me personally though a few people mention it interferes with sleep if taken late. Tomorrow at my desk I'll dig through my notes for any details I saved.

SteadyLedger54archiveAug 11

I finished the full 14-week mitochondrial protocol yesterday. Overall I didn't notice major changes besides some extra stamina, and my regular yearly labs showed little difference. The standout was the opening week on NAD alone when I could mow the entire large yard in heat without needing breaks despite being older, heavier, and using a manual mower. I'll keep NAD going at minimum and might run the whole thing again next year since I have extra on hand. Still wondering if NAD by itself was the main driver.

PatientTimber12archiveAug 11

Haven't come across nasal NAD before. If avoiding more shots is the goal, oral precursors such as NR or NMN can also raise NAD levels.

SlowLedger31archiveAug 11

On the mitochondrial topic I've been seriously considering adding ATX304 though I keep second-guessing the idea.

WryCompass63archiveAug 11
↳ replying to @WarmWillow50 (opening post)

I did this exact protocol and really enjoyed the results, enough that I'm planning to repeat it soon. The energy boost from SS-31 surprised me.

ClearBramble14archiveAug 11
↳ replying to @GreySparrow51

A friend experienced the same type of reaction after pausing sermorelin.

CopperAlder51archiveAug 11

I took everything in the morning when I ran it and started MOTS-c low to test tolerance, going 1 mg then 2 mg then 3 mg on MWF the first week. Better to discover any allergy at a smaller dose than 5 mg. It ended up fine and I still use it now.

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