Anhedonia from retatrutide doses and options for mood recovery with tirzepatide or TRT

Same here, the flat feeling still hits hard some days but Semax changed things for me. Not sure if you have tried it. I also cut the reta dose back and stayed on tirz only, and four days later the scale finally moved again though it might be coincidence.

You are doing fine, the weight is already down and you are clearly stressed. Skip the lawn tonight, just relax and do something that feels good. Tomorrow you can regroup and the progress will still be there when you are ready.

No clear answers from me but I have felt the same drop in drive after losing a lot of weight. A year or more of low calories makes the body want to conserve energy so you feel like doing nothing, even before the GLP effects are added. You cannot eat more without regaining and you are probably already at the point where extra movement just makes the body more efficient. One option some people look at is a different compound at low dose that can still support loss with fewer sides and might let you lower the current doses.

Let me shorten that for you. You are looking forward to starting testosterone.

With 120 already gone and only 20 left I would shift focus to how you look and feel overall instead of the scale number. It is a long game and the final weight target is just something you made up. If you can do the things you want then you are basically there. Body composition will keep improving if you stay consistent.

Anhedonia means reduced ability to feel pleasure from things that used to be enjoyable. It shows up in depression and some other conditions. There are social and physical versions. Signs include lack of drive, feeling numb, and not looking forward to anything. Causes are still being studied but it ties into brain chemistry changes.

Might sound simple but set up small rewards for the tasks you want to do. Tell yourself that finishing the yard work gets you something you actually want, write it down, and let someone else know you are committing to it. Then follow through and collect the reward.

First give yourself credit, most people never manage what you have done. Everything has a downside though. If motivation is already low I would not add another compound that can flatten people even more. Some report the same drained feeling on other options too. Maybe just push to the goal then drop to maintenance. Quitting the stronger doses made me feel better overall. You are close.

I do not have the motivation problem but dating, hobbies, and even cooking all feel flat. Work stuff still fires me up though.

I feel the same stall about 15 pounds out. Probably need to raise the current doses to finish the last bit, then start the testosterone. After that you can eat a little more, train hard, and adjust the goal. I have to keep fertility so I cannot go that route but bloodwork would be useful.

Track calories even if you do not want to. The meds are not magic and you need real numbers if you want to add muscle. I lost a lot of fat and gained muscle once I saw my levels were low. TRT will probably fix a big part of the motivation issue. Also consider easing the doses back once you start replacement so you can focus on lifting and recomp instead of more loss.

I have not lost as much but I hit my target and sometimes felt the same flatness. Lately I have been busy again with yard work and projects around the house. It passes.

The flat feeling seems to depend on which compound people use. I got it on two of them but not the third. Have you tried switching things around? It is not something I can tolerate for long.

I had treatment resistant depression for ten years and anhedonia was a big piece of it. Tried many meds with bad sides. One session with a certain mushroom reset things for me. I started writing again the next day and after a couple more spaced out sessions the depression stayed gone for three years now. Not for everyone and family history of certain conditions means skip it.

Go talk to a therapist.

I have noticed the same drop in drive. Often happens after hitting a big goal and then nothing new is lined up. TRT helped other things but not that specific issue. Setting a fresh target like a trip or project can help get the spark back. You have plenty of other things going on already.

Libido has been low since the weight came off and feels even lower now. Eating right, staying hydrated, running a couple times a week, but it takes everything I have. Starting to affect the relationship. Might check levels but local doctors do not seem interested.

You look good already from the photos I have seen. People keep telling me the same thing. If the goal number is the only thing left maybe raise calories for a bit to reset, or ease the doses down slowly toward maintenance. That can reduce the emotional drain and let you focus on recomp. You might end up happier at a slightly higher weight once muscle is back.

Dealing with the exact same lack of drive and joy right now even though the weight is down. Friends who tried a certain wakefulness med said it gave them energy back so I ordered some and will test it. Tried other things like NAD with no noticeable change. 120 pounds is still something to celebrate.

Long term I run test with another compound as the main items. Both on higher and lower amounts they improve confidence, energy, and drive. The second one especially helps mentally, sexually, and with training. Recently cut with reta and growth hormone then took a break and weight rebounded a bit. Looking forward to adding it back while keeping the other stack.

120 pounds is huge and worth feeling good about. The last 20 are annoying but the real issue might be fixating on that number and letting it feed the flat feeling. Prioritizing getting some joy back matters more than the scale. You already have a full life and are still in your 50s so there is time to add new targets.

You have been helpful to read across threads. Lots of good suggestions already here. Hope something clicks for you.

Similar spot here so I set fixed workout times, added cardio, and cut social stuff to focus on family and work. Dropping alcohol helped the slump a lot. Occasional use of a certain mushroom also seemed to lift the flat feeling for me.

Sorry you are in the gray area right now. Therapist points that helped me: you do not owe constant happiness to anyone, and this will not last forever. We are all here while you work through it.

I had to stop tirzepatide at higher amounts and then retatrutide at 4mg because of the same lack of feeling and motivation. Three weeks after stopping I had more energy and my mood improved. You are using fairly high amounts so lowering the dose a little could help. I am still using cagrilintide and waiting on another compound. I only need a few more pounds but the last months left me with zero drive.

Anhedonia is rough. I have no interest in anything and usually have to push myself to eat. The small amount of enjoyment I started with has disappeared. I wanted to lose weight so I would have more energy for tasks but now I can hardly get myself to exercise.

This might sound like pointless advice but try something different from your usual routine. Maybe read something positive. You could be stuck in a negative loop and a bit of uplift might help break it.