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Retatrutide 1 mg/week – When Did It Start Working for you?

32 replies33 peopleJan 5, 2026β˜† Follow
Summary

At 1 mg retatrutide per week, after how many days or weeks do people notice appetite changes and weight loss, and what side effects show up?

Users report highly variable onset: some feel appetite reduction and less food noise within hours or a couple of days at 1 mg, while others see nothing until reaching 4 mg or higher. Weight loss often appears in the first or second week, frequently attributed to water loss plus calorie reduction. Side effects mentioned include fatigue, constipation, burping, skin sensitivity or allodynia, elevated heart rate, and occasional nausea or indigestion, though many experience none at low doses.

What this discussion establishesWhere people disagree

Whether 1 mg is sufficient for meaningful appetite control or if most people need to reach 4 mg before effects appear.

Still open

How long allodynia or other side effects typically last and whether they reliably resolve with continued use or dose adjustment.

Nothing here is advice.

32 replies Β· 33 people
LevelTimber39archiveopening postJan 5

Right now I'm taking this medication at a total of one milligram each week, divided into two half-milligram shots. If anyone else is on a comparable amount, how soon after beginning did hunger decrease become noticeable? At what point did the pounds start coming off? Did any unwanted reactions show up? I'd appreciate hearing about specific time frames and real stories from others.

PlainSignal69archiveJan 5

It took around three days before my appetite began to decrease on that weekly one milligram amount. Weight came off for me in week two. Unwanted reactions included a few short periods of feeling tired during the opening two or three weeks and some abdominal unease that never reached the point of nausea.

BlueTimber78archiveJan 5

I began with roughly comparable amounts, though it's tricky to measure precisely because of the smaller containers and extra liquid. I'm injecting on a three-day cycle, assuming it's close to what you're doing. For the first noticeable change, it came around the second shot, but it's tough to separate the actual effects from what might be in my head. On the weight side, I've been logging my food intake starting from the initial injection and checking my scale at consistent times daily. The drop happened right away, likely from reduced fluid and swelling combined with eating less. That's typical whenever I cut back on calories, based on past tries. As for downsides, I get some burps without the rotten egg smell, trouble going to the bathroom which isn't aided by lower intake, and minor stomach upset after greasy food. Also occasional headaches from not drinking enough.

NorthKettle39archiveJan 5

After three days the cravings for food finally went away. The increased touch sensitivity on my skin is a downside though. Still I'm really happy with my current appearance.

WarmSparrow96archiveJan 5
↳ replying to @LevelTimber39 (opening post)

I'm sticking with the same amount for holding my weight and working on body composition changes, taking half a milligram on a three-day cycle. It took around a month to a month and a half before I noticed the reduced hunger. Earlier in the spring I dropped roughly twelve pounds and I've kept that off because that's where I wanted to be. These days I'm focusing on maintenance while trying to turn about five pounds of fat into muscle and get the advantages for insulin sensitivity that this offers. Raising the amount makes it difficult for me to reach my protein targets needed for building muscle. Also, the higher dose along with all the protein required might make digestive problems worse for my situation.

WryThistle67archiveJan 6

This is my initial experience with these compounds. On the third of January I gave myself an injection of one milligram of that substance. The day after, I found myself skipping over the snacks in the cupboards that I usually sample and end up finishing entirely. There wasn't any queasiness or other reactions. My reduced calorie intake began on the twenty-ninth of December, making it hard to know how much of the drop on the scale came just from the shot since I had already been cutting back. Still, a good amount of that came from fluid.

BrightSignal73archiveJan 6

Effects started showing up once I hit four milligrams. Six milligrams gave stronger results. My schedule was two milligrams for four weeks followed by four milligrams for four weeks repeatedly. That final four milligram dose stood out clearly. Side effects stayed away until that stage. Now red itchy spots appear where I inject because of the substance itself.

LevelThistle44archiveJan 7
↳ replying to @WarmSparrow96

I've been wondering how well I'm doing with tracking my fiber amounts and staying hydrated.

CopperSignal33archiveJan 7

I began with a weekly dose of 0.5 milligrams. The urge to eat constantly vanished almost immediately yet I still managed three regular meals without going overboard. During the opening fourteen days I dropped six pounds though a large share was probably just fluid. The sole issue appeared in my runs where tiredness rose and anything past ten miles grew tougher while I trained for the marathon. Later I moved to the same amount spaced every two weeks. Now I am stopping the substance completely until the race ends since juggling both proved unworkable. Early next March I plan to restart at either half or one milligram for several months once my longer training runs shorten.

ClearMeadow20archiveJan 7

Before starting this, I was already following a diet routine. Once I added the compound, I soon saw how much simpler it became to follow through with my eating habits. I even skipped one meal entirely during the day. I did wonder if this could just be a placebo response, but then I figured it doesn't matter as long as the results are there.

SharpBeacon98archiveJan 7

People differ quite a lot from each other. Seems like personal trials are what matter most.

CopperQuill51archiveJan 7

Beginning at point five made me aware of altered eating urges after only two days.

KeenWillow91archiveJan 7

Right now my dose is around 4 milligrams and I've been taking it roughly six weeks. Haven't noticed any bad reactions or problems at all, and my appetite is normal. Still, the scale shows I've dropped 24 pounds, which means it's working I guess lol.

LevelPebble75archiveJan 8

Typically when upkeep seems necessary I give myself a single milligram injection once weekly across three or four weeks. Appetite changes show up right after getting out of bed the morning after, along with a faint queasy feeling like motion sickness that lingers for two or three days. My main drop in weight happened around eighteen months back, so these days I only bother with short upkeep phases if my eating starts slipping out of control a little πŸ˜‚πŸ˜‚πŸ˜‚

KeenAnchor62archiveFeb 12

Six weeks back when I began, three or four milligrams were the minimum required before hunger decreased at all. Yet the boundary proved narrow between an effective amount and excessive reduction that left me unable to consume even a thousand calories daily. On a few instances I went overboard with it. Locating that ideal level turned out somewhat challenging.

PlainAnchor18archiveFeb 12

My beginning dose was one milligram each week and the drop in food thoughts plus mental clearness appeared right away. The hunger reduction felt light like others describe so I could still hit my nutrient targets without trouble. I'm heading into week three at one point five and that extra half really boosted how satisfied I get during meals leaving me unable to finish what my eyes want. Getting used to that means I skip eating while working and later can't make up the difference. It's also been over eighteen months since I last tried a comparable medication and the previous one never went past a milligram because it left me feeling terrible.

BrightSignal76archiveFeb 12
↳ replying to @NorthKettle39

It felt unusual to notice skin sensitivity right away with the first amount. I held off on raising the dose until those odd sensations disappeared. Rubbing a particular area never bothered me, yet fabric brushing over my body was like pins poking outward from beneath. Eventually I went up to twelve milligrams and the issues didn't return. These days the main trouble is constant thoughts about eating, or maybe I've just grown tired of the same meals every day.

QuietTimber26archiveFeb 12

Over eight weeks I slowly worked my way up from zero to eight milligrams by injecting four milligrams every eighty-four hours. Around six milligrams I started to experience effects similar to GLP. Things got really strong once I reached eight.

SlowSignal13archiveFeb 13

Began with the smallest amount and noticed changes by the next day. Appetite faded yet I could still have food if the urge hit. Fullness came on quickly the day after that. Now in week two at the higher dose I rarely feel hungry and get satisfied after just a couple mouthfuls including liquids. My spouse is also in his second week and the changes are kicking in for him too. He feels less hungry and fills up sooner. He skipped meals entirely today even after the gym and a walk so he’ll probably have to make himself eat some protein anyway.

SteadyQuill55archiveFeb 14
↳ replying to @BrightSignal76

Allodynia appeared right after that first injection of tirz at 2.2 mg. The next morning any pressure on my skin caused mild discomfort. I quit pressing there and soon ignored the whole thing. Pants brushing my legs still set it off. Half a year later the feeling has stayed exactly the same no matter the amount taken, now up to 8 mg. I barely register it anymore. The storybook girl swapped her crown and voice for walking that hurt, all to chase some unworthy guy whose feelings might have been twisted anyway. My own exchange gave me far more while costing far less.

NorthMarble42archiveFeb 14

I began with a 2 milligram amount and noticed appetite reduction after just a couple hours. The best level for dropping pounds didn't come until I got to 4 milligrams. I went up as far as 10 but lowered it again to 8 because the touch sensitivity started feeling strange. These days I'm at 4 milligrams while getting ready for physical competitions. My process began during August and brought a total reduction of about 22 pounds. There wasn't a large amount of extra body mass I needed to shed anyway.

RustMarble78archiveFeb 19
↳ replying to @BrightSignal76

Allodynia showed up for me once I reached two milligrams. While this symptom is bothersome, the remaining benefits from Reta are excellent, and I hope the issue disappears eventually.

RustKettle12archiveApr 16
↳ replying to @LevelTimber39 (opening post)

I've reached week four on this dosing routine, giving myself half a milligram each Tuesday morning plus Friday evening. The changes appeared almost from the beginning. Resting heart rate, heart rate variability, and sleep show barely any shift. To give some background, I shed one hundred sixty pounds about nine years back by cutting carbs, lifting weights, and taking hikes, without ever trying a GLP-1 before. This compound helps offset the weight creep from perimenopause hormones. My meals stay the same as beforehand, heavy on protein with moderate fats and low carbs where the only packaged item is a shake, though I simply take smaller helpings now. That has produced an eleven pound drop across three weeks, which still surprises me.

NorthKettle44archiveApr 16

From trying both compounds their effects on appetite feel quite distinct to me. Tirz seems to dampen all signals evenly and strongly letting me decide meal times while halving how much I consume before satisfaction sets in. That struck me as genuine appetite control. On the other hand with Reta putting off hunger too much causes it to spike suddenly into extreme need as if starving for days yet just a few mouthfuls leave me full and content for extended periods. The swings can be quite unpredictable at times. I noticed these patterns across the lower to mid doses I tried.

RustCompass19archiveApr 16
↳ replying to @NorthKettle44

My trials with the two substances showed overlaps yet distinctions too. Direct comparison isn't feasible because tolerance from the earlier one had already developed when testing the later. Five shots at low level spread across eight weeks for the first. Appetite reduction hit hard, most intense a few days following each dose. Hunger rarely appeared and satisfaction came rapidly. Caution with portions mattered initially. Constipation stood out as the primary drawback, prompting more vegetable inclusion. Workouts left me feeling less powerful. Four days back I began the newer at a small amount. Desire for food disappeared the next day. However eating once begun proved hard to cease. Ignoring food choices risks constipation soon. Terrible sleeplessness occurs even now, leading me to consider dropping it.

BlueAnchor24archiveApr 21

After taking the third shot at that dose level I believe the effects are noticeable. On certain days eating feels impossible and I must compel myself to consume something while on others like the previous evening I ended up eating excessive candy. My weight has decreased by around one point two kilograms yet I remain very swollen constantly. I hope this feeling disappears before long. I'll keep using the current amount for at least a couple more weeks prior to attempting a higher one to observe the outcome. It can be challenging to determine if the lack of appetite is normal or caused by the compound.

NorthBramble10archiveApr 21

Personally the effects hit me right away the next morning along with less hunger and some issues like exhaustion my digestion slowing down frequent tiredness and those smelly burps. So far the scale shows just a two-pound drop after about ten days yet I'm confident my system will adapt and bring solid improvements in roughly a month.

SteadyMarble46archiveApr 21

During the following week at one milligram the appetite reduction showed up. The opening week at half a milligram brought no changes although I realized the system needs gradual adjustment to the compound. Taking beyond three milligrams each week holds no appeal for me. Meals ought to stay easy to handle. Going without food for several days feels simple.

CopperQuill76archiveApr 21
↳ replying to @LevelTimber39 (opening post)

Began treatment on the tenth of April this year using a single weekly milligram dose given as one injection each time. Effects showed up just hours later. I injected at three in the afternoon and normally want a bite by eight yet felt zero urge that evening. Snapped pictures the night before and again first thing the next morning and all the swelling around my middle had disappeared. Roughly ten days later the scale shows four and a half pounds less. I train five or six days weekly on a push pull legs upper lower plan followed by fifteen minutes of rope skipping. Pulse stayed higher during the opening seven days then eased off. Exhaustion hits hard without enough carbs. I sip warm prune juice each night to keep digestion steady and it has worked. Hunger stayed very low at first but now I finish full plates and notice actual appetite signals again. I used to consume cannabis daily and have kept doing so yet the pull toward it has fallen off sharply. Given my habit forming nature old cues no longer pull me in. That shift helps me stay on task with work studies lifting and meals.

PatientTimber64archiveApr 22
↳ replying to @BlueAnchor24

The one milligram amount seems effective in my situation. Hunger feels reduced yet food intake remains possible.

IronSignal60archiveApr 29

I've been on this for four months now, and I'm still taking just the one milligram dose. Appetite isn't there much anymore, and those urges for food have pretty much disappeared. Reaching even fifteen hundred calories feels tough since I'm always satisfied. I've dropped twenty pounds so far, yet things seem to be moving in the right direction.

ClearQuill84archiveApr 29

I had my third one-milligram injection the day before yesterday. Noticeable effects kicked in almost straight away. Cravings dropped sharply right after the opening dose. Reaching my usual protein target now feels like an effort. Over the past three and a half years I've kept to lower carbohydrate meals, spaced-out eating windows, and just two sittings with food each day. Roughly two kilograms or four point four pounds came off within a single week. My partner remarked that my face looks thinner. Outfits sit much looser, so the belt has to be pulled in more. I step on the scale every Friday and will check then for any further shift.

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