Community β€Ί Results & Progress

What to add?

43 replies16 peopleJul 19, 2026β˜† Follow
Summary

Stalled on retatrutide after semaglutide with ongoing evening hunger, should I add tirzepatide or cagrilintide?

The original poster lost twenty pounds early on semaglutide but then stalled for eight months, followed by only three pounds lost over three months on retatrutide while still facing strong evening hunger. Multiple replies stress that current doses, calorie intake, and body metrics are needed before any recommendation can be made. Suggestions lean toward trying tirzepatide for better appetite control rather than adding cagrilintide, which users report loses effectiveness quickly. A side debate emerges about whether lifestyle factors are being ignored versus medication adjustments alone.

What this discussion establishesWhere people disagree

Whether the poster is overly dependent on medication without sufficient lifestyle effort, and how much personal diet or dose information must be disclosed before advice is given.

Still open

Which medication adjustment would actually work without the missing dose, weight, and intake numbers.

Nothing here is advice.

43 replies Β· 16 people
AmberMarble76archiveopening postJul 19

I've had my research subject on semaglutide for roughly twelve months. They dropped twenty pounds early on but then stalled completely. Switched to retatrutide three months back and only three more pounds came off. Evening hunger remains intense, so considering stacking cagrilintide or tirzepatide. Which addition seems preferable?

BrightCompass57archiveJul 19

It seems like a stronger overall approach could help out. I have this feeling the substances are supposed to handle everything on their own. Does the schedule include any workouts at all?

AmberCinder46archiveJul 19
↳ replying to @AmberMarble76 (opening post)

I'm curious about the amounts being used and the total pounds that need to come off.

PlainAlder11archiveJul 19

I agree with the comment above. It feels like we're heading into this without any insight on our end.

PlainCompass54archiveJul 19
↳ replying to @BrightCompass57

The individual described feeling incredibly hungry. No matter if a fitness schedule is followed, the medicine fails to produce the right effects.

AmberCinder46archiveJul 19

It really hinged on the medical reason for the prescription and whether any gradual dose changes took place at the beginning. Staying no higher than half a milligram as the smallest amount that helps kept things at a basic continuing level for me.

PlainAnchor67archiveJul 19
↳ replying to @AmberMarble76 (opening post)

Which amounts are typical? What's the daily energy total and nutrient split like?

KeenPebble33archiveJul 19
↳ replying to @AmberMarble76 (opening post)

Following what others mentioned, sharing the amounts used would help. In my case I think adding fifteen milligrams of tirz while stopping reta makes more sense since tirz controls appetite suppression far more effectively in general. I only think about bringing reta back after reaching a stall on tirz by itself. Reta also tends to lower heart rate variability while raising pulse, so that leads me to prefer beginning with tirz instead. Combining tirz with sema tends to wipe out cravings and move past any sticking point. Hoping things work out well.

KeenPebble33archiveJul 19

I wouldn't bother with the latest option either. It works okay for appetite at first but tolerance sets in fast. When I tested it myself, stopping didn't alter my appetite levels or scale numbers at all. The pricier alternative still costs too much in my view. The standard pair should deliver solid progress, so work through any stall there prior to considering upgrades.

PatientFenwick91archiveJul 19

Like what others have said, knowing the earlier and present amounts of each substance would be helpful. When the strong hunger continues, maybe the level is insufficient or this substance just doesn't fit well alone. People mention not depending on it to manage the effort, but it needs to simplify the effort instead of making it tougher. To be honest, if it all came down to self-control, we wouldn't be on these GLP-1s.

KeenPebble33archiveJul 19

In my experience reta shows weak binding toward the glp1 receptor so appetite control usually falls short of what tirz delivers. The big drop in body weight from reta actually comes from activity at the gip and gcgr receptors instead.

BrightCompass57archiveJul 19
↳ replying to @PlainCompass54

I realize now that my words probably made it seem like I expected substances handed over so I could skip putting in any work myself.

PatientFenwick91archiveJul 19
↳ replying to @BrightCompass57

That's not accurate at all. What sign is there of no work being done? Nothing would drop without some attempt. It feels wrong to claim this about someone who already dropped twenty three pounds, hit a plateau, and came here looking for tips. I'm curious though, in what way would working out fix intense appetite? The medications are meant to handle most of the process. This explains why demand for those treatments keeps growing, since they simplify shedding pounds.

BrightCompass57archiveJul 19
↳ replying to @PatientFenwick91

I continue to hold that this relies heavily on substances. No need for agreement, but my evaluation remains firm. Working out certainly assists in managing physical functions through multiple methods. Adjusting meals to include items that promote a sense of satisfaction represents another topic worth mentioning. An approach limited to medication alone works okay, yet it falls short when considering overall wellness and effectiveness.

AmberCinder46archiveJul 19

Knowing the amounts taken and the present body mass index would likely make sense of most or even all of this. Eight months using semaglutide brought zero change on the scale? Then three months with retatrutide and just three pounds came off?

IronFenwick84archiveJul 19
↳ replying to @AmberMarble76 (opening post)

I'm puzzled by the phrase my rs. Does that point to you or another person?

KeenKettle50archiveJul 19

I noticed those medications do nothing for me unless my daily intake stays below what I burn. Anyone want to mention the meals they're having?

PatientFenwick91archiveJul 19
↳ replying to @BrightCompass57

There's not enough background here to reach any conclusion. Most people are requesting extra details, yet this person is accusing the original poster of depending only on medication while putting in zero work. That kind of remark feels misplaced inside a community meant for support. The actual query concerned ways to handle intense food cravings. Mentioning workouts fails to tackle the core issue. The note about activity improving overall body function probably refers to appetite control. My earlier remark was that medication covers a big portion but leaves room for other factors. Those two ideas are not identical.

BrightCompass57archiveJul 19

This discussion appears to be veering off course. I had no desire to cause offense and simply aimed to assist using beneficial approaches. A significant concern isn't being tackled, resulting in these unfavorable effects after the beginning success with shedding pounds.

PatientFenwick91archiveJul 19
↳ replying to @BrightCompass57

I get that you didn't mean to offend anyone, yet deciding if the original poster relies on substances isn't something any of us can properly determine. This forum isn't suitable for making those sorts of evaluations.

SteadySparrow75archiveJul 19
↳ replying to @IronFenwick84

People on forums and Reddit would bring up needing details on doses or methods for their test participant when they actually meant themselves. Calling the items lab exclusives only meant moderators left alone any threads about folks trying those unregulated compounds on their own.

BrightCompass57archiveJul 19
↳ replying to @PatientFenwick91

Being truthful fits right in here. Your idea of criticism matches my way of handling reality. Clearly a problem exists that goes further than the substances failing to reduce hunger. Eating habits along with workout routines need checking before adding extra compounds. I'll stop right there.

KeenKettle50archiveJul 19

There's little use in bickering with one another while the thread creator remains unresponsive.

PatientFenwick91archiveJul 19
↳ replying to @KeenKettle50

Being called dependent on drugs openly due to a small number of statements would keep me from answering as well.

AmberMarble76archiveJul 19
↳ replying to @BrightCompass57

I'm puzzled about how I led you to believe that. At 53, I stay quite fit despite my age. Twice weekly I attend pilates classes, and I also hit the gym on two separate days each week. Working as a waiter keeps me on my feet covering several miles during five shifts weekly. Why did you assume I depended on medications, or did you just guess?

BrightCompass57archiveJul 19
↳ replying to @AmberMarble76

I guess I read the situation wrong and jumped to conclusions without enough info. There wasn't much discussion of anything else so it looked like only medications were in play. Sorry for that mixup. Still I went ahead and checked out meal options more carefully to locate items that help with staying satisfied longer even when including another substance for hunger control.

KeenKettle50archiveJul 19
↳ replying to @AmberMarble76

Hey dude my mother sells stuff at sixty two and stays on her feet the whole shift yet she added roughly ten pounds while developing high cholesterol. I stepped up and adjusted what she eats by including more roughage. Metabolism slows down with the years and that part is unfortunate. What's the precise meal plan you follow?

AmberMarble76archiveJul 19
↳ replying to @PatientFenwick91

This is my first time on the site though I've used peps before. The comments really took me aback. All I sought was input on personal results from trying those two things. It felt like they saw me as some lazy overweight person after meds πŸ˜‚

AmberMarble76archiveJul 19
↳ replying to @BrightCompass57

Which section of my message indicated I avoid physical activity or nutritious meals?

PlainCompass54archiveJul 19

The person seeking input wants details on the drug itself rather than lifestyle changes. No need exists for anyone to share their precise eating patterns. Plenty of individuals lack a fixed meal routine and that works fine. Consuming balanced items can happen without logging every bite. My ADHD turned logging intake into something draining and impossible to maintain long term. Monitoring everything only increased the constant mental focus on eating. This medication has made daily life better by reducing those intrusive thoughts and removing the need for constant oversight. I keep moving regularly and favor natural foods yet can now have an unplanned meal out or skip activity without any shame. That shift has helped my mood and day to day well being quite a bit. Still I think the current amount being taken matters here.

AmberMarble76archiveJul 19
↳ replying to @BrightCompass57

So if that holds up, nobody here has any reason to use those shots. Everyone could simply improve what they eat and stay more active instead. Are you actually sticking to that plan yourself?

BrightCompass57archiveJul 19
↳ replying to @AmberMarble76

My eating habits stay extremely disciplined and I push through twenty one tough lifting sets plus sixty minutes of cardio daily. I handle that load fine without the medications yet I would never demand it from anyone else at the same intensity. Those habits existed long before I started the compound roughly a month ago. The idea is to explore every possible factor when aiming for a goal. Hunger pangs hit harder if nutrition is poor by the way. One upside of this process is the chance to keep improving over time. To the original question people really should not begin the medications until they have already adjusted other areas first. This amounts to a full lifestyle.

CopperSignal27archiveJul 20

Without knowing your present body mass, stature, desired mass, reta dosage, plus the period of usage so far, any reply stays pure speculation. The sole details available consist of age along with a twenty pound reduction from ozempic.

SteadySparrow75archiveJul 20
↳ replying to @BrightCompass57

Perhaps now is a good moment to let the thread starter lead the discussion. Those recent questions look useful for steering the conversation back toward the main topic.

KeenKettle50archiveJul 20
↳ replying to @PlainCompass54

That point might be key here since weight hasn't budged at all. That medication packs a punch as a GLP agonist, however keeping calorie intake right at or beyond what's needed for balance stops any drop on the scale. Maybe thyroid function was looked into already, as reduced activity there can strangely boost feelings of hunger.

AmberMarble76archiveJul 22
↳ replying to @BrightCompass57

Thanks for sharing that. Eighteen months back I totally overhauled my eating habits and I stay active too. I always treat medication as the final option and I only joined the discussion to hear what approaches others have tested for that nonstop appetite signal at night. I already handle my meals and workouts fine so I skipped mentioning them. My question was simply why this gets labeled as relying on drugs when all I described was the evening hunger that still hits hard. I just wanted to learn personal experiences with weight loss without hearing about those particular medications since they seem to point back to needing more lifestyle tweaks anyway.

PatientFenwick91archiveJul 22
↳ replying to @AmberMarble76

Wasn't me who labeled you as addicted to meds. A different member posted that remark and I totally disagree. Your struggles hit close because I've dealt with something comparable before. No solutions come to mind for your queries even though I'd like to offer some. You've got my backing here.

NorthWillow72archiveJul 22
↳ replying to @AmberMarble76 (opening post)

Hey there newcomer, this place gets all sorts of replies on different subjects. Folks here enjoy lending a hand whenever possible, and you might find it useful to skip over the ones that don't appeal to you. Regarding what you asked about the medication used for a year with no results after eight months, could you share details on how you increased the amounts? Same for the other one taken for three months with minimal change in weight. Since you're already quite active, what are your present and target weights? Maybe we can begin again from here.

PatientPebble79archiveJul 22
↳ replying to @CopperSignal27

The person never gave the details we asked about. Instead they right away start complaining that the community dislikes beginners along with some other inflammatory remarks. They mention dropping twenty pounds with that medication across a year and then ask what comes next while saying they refuse to check earlier threads on the subject or reply to questions. A useful exchange might have happened yet without any word on the amount she's using or any limits on intake it comes across as expecting pointless speculation from everyone. Folks here are willing to assist though it resembles trying to solve a puzzle that lacks the hints.

WarmPebble45archiveJul 22
↳ replying to @AmberMarble76 (opening post)

I think metformin might come in handy sometimes. For fat around the middle at my age, tesamorelin has the added benefit of preserving muscle. When it comes to eating habits, going low carb and skipping meals at times works well. The most effective approach involves going without food for about a week, even though it feels pretty rough, yet it improves not only the pounds but also general well-being.

CopperSignal27archiveJul 23

I'm attempting to clarify for the thread starter the reason behind those unhelpful replies. Lacking the personal details I asked for previously, replies can't be tailored to specific drug needs, leading to comments based on individual views regarding shedding pounds instead of matching what you described.

Add your experience

If you have tried it, this topic is still open. Sign in to reply β€” it takes a minute.

What to add? Β· ZyraTrack Community