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Best weight loss peps that are not GLPs?

41 replies20 peopleMay 2, 2026β˜† Follow
Summary

What weight loss options exist besides GLP-1s that avoid anhedonia or effects on reward pathways?

Users suggest alternatives like Cagri via amylin receptors, Mots-c, Tesamorelin for visceral fat, and non-peptides such as bronchodilators or thermogenics. Some note that weight loss itself can cause mood issues and anhedonia regardless of the compound. Others highlight risks with certain options like clen or BAM-15 and recommend starting very low or combining items carefully. Bariatric surgery is mentioned as a more permanent route for some.

What this discussion establishesWhere people disagree

Participants differ on safety and tolerability of compounds like clenbuterol, BAM-15, and eloralintide, with some calling them too risky and others sharing positive past experiences at low doses.

Still open

Whether any alternative can match GLP efficacy for the original poster without eventually causing similar mood or reward issues.

Nothing here is advice.

41 replies Β· 20 people
BlueBeacon34archiveopening postMay 2

Following a couple of years experimenting with options, I've decided these medications simply aren't for me going forward. They produce severe emotional flatness in my experience, and one variety also brings on genuine fear along with restlessness. After countless personal tests I've confirmed the substances are the source. I'm basically accepting I'll stay a little heavier than ideal despite keeping my food habits and movement routines solid, which leaves me feeling down. Still the downsides make them not worthwhile overall. What other options might exist that avoid influencing pleasure related brain systems?

CopperAlder51archiveMay 2

I've heard cagri acts through amylin pathways unlike glp1 types so it could be interesting to explore further. Reports also mention mots-c along with tesamorelin for shedding pounds though the second one mainly targets visceral fat.

BlueBeacon34archiveMay 2
↳ replying to @CopperAlder51

I appreciate the response. Perhaps putting together several of them could work out well for my needs.

CopperAlder51archiveMay 2
↳ replying to @BlueBeacon34

That's fine. I went with Cagri on its own before adding the others separately. The quantity stays small regardless. After that I checked what combinations worked for me. I kept the initial amount for Mots-c small as well and raised it gradually. Reactions show up for some users.

KeenPebble33archiveMay 3

You seem like the perfect person for this new substance once it shows up through unofficial channels. The stuff matches glp1 agonists when it comes to dropping pounds, whereas the alternative looks like it packs only half the power. That alternative still beats doing nothing at all, so going with it in the meantime makes sense as the top choice right now. The third item handles deep belly fat really well, so using the alternative together with this third one could turn out useful. I have not tested any such mix myself.

BlueMarble20archiveMay 9
↳ replying to @KeenPebble33

This also leads to an inability to feel pleasure.

LevelSignal24archiveMay 9

Before starting those GLP1 medications I had already run into unexpected mood shifts such as low spirits and a loss of pleasure whenever I dropped weight. Folks have long noted this as a typical result of shedding pounds. Staying too thin tends to hurt emotional well-being. In your situation though the problem might not trace back to that since the drug itself could be hitting the brain's reward system straight on.

KeenKettle50archiveMay 10

Most other peptides take WEEKS to see results.

QuietFenwick11archiveMay 11

Cagrilintide must be really strong since they decided to team it up with semaglutide in order to offer it for purchase.

SlowSignal40archiveMay 11

I moved away from that substance since I prefer to bypass anything involving dopamine and instead used things that dilate the bronchial tubes along with agents that reverse anhedonia including thermogenics which produce euphoria such as various fat burners nitric oxide enhancers and the like.

KeenKettle50archiveMay 11

Epicatechin is not a peptide. It is a plant polyphenolic extract.

SlowSignal40archiveMay 11
↳ replying to @KeenKettle50

I didn't claim otherwise at all. Nearly everything from my earlier list comes as tablets. Salbutamol also exists in a nasal inhaler. Carnitine comes as both tablets and shots.

PlainAnchor17archiveMay 11
↳ replying to @SlowSignal40

I really like taking salbutamol by mouth. It works well, stays harmless, costs little and comes in handy when dropping fat. It curbs appetite or adds a lift during low energy moments. It also holds onto muscle tissue enough that skipping meals with it improves how the body recomposes. Having some around makes sense for that purpose alone. I've never tried the version you inhale through the nose and it comes across as risky.

SharpTimber40archiveMay 11

I'm on board with that view too! Or maybe even a comparable option πŸ™‚

SharpCinder28archiveMay 11

Less costly than a burial service one mix against the other I used this medication for roughly sixteen months now and right now divide seven point five milligrams across each week after mixing another compound I began taking one milligram on the first weekday with plans to repeat the following weekend day my aim was for the pairing to restart progress once I finished healing from shoulder surgery and help return me to top form this item faces regulation in certain regions over safety concerns elsewhere authorities may treat it as hazardous leading to tougher punishments even for basic possession in another country distribution risks up to fourteen years locked away informal reports like that led me to test a comparable substance myself the year before in addition to threatening cardiac health I dealt with intense muscle soreness and spasms from standard amounts despite using plenty of an amino supplement at the same time

SlowSignal40archiveMay 11

Way back around the start of the millennium my workouts for getting in shape while using that stuff went really well and had no problems at all. I even took part in competitions during that time. The improvement in results was huge. Plenty of people I know handled it fine too yet there's this one guy who passed out during a game following his 25mg intake. Mine was 40mg. At that point he weighed 65 kilograms and I was at 120.

SharpTimber40archiveMay 11

I removed my recommendation. I did not know it had such bad risks. Do not take drugs kids.

KeenKettle50archiveMay 11

My current regimen includes 250 micrograms of the CJC Ipamorelin blend along with 7.5 milligrams of reta. Several days back I tested an injection of BAM15, starting at 25 milligrams the first time. The next day I dropped to 5 milligrams after the larger amount triggered intense heart pounding. Claims suggest it avoids any body heat rise or pulse spikes that DNP produces, yet no trials exist so who knows. Extreme tiredness hit me yesterday following that smaller injection. I cannot tell whether the substance triggered it, given my mother had a cold around then even though I showed zero signs of illness. My resting pulse sat at 120 from early morning straight through five in the afternoon. It could easily be unrelated. This morning right after a bowel movement the scale read two pounds lighter than the day before. I always step on it at the same time after using the bathroom so the drop was not fluid.

PlainAnchor17archiveMay 11
↳ replying to @KeenKettle50

Whoa that approach to dosing comes across as pretty risky. Why not begin at a low amount like one milligram and raise it bit by bit to understand the effects? I've considered bam15 myself and reading what you shared actually increases my curiosity about trying it since it seems to deliver results.

PatientHarbour23archiveMay 11

I started out using an incredibly minute quantity of the substance because its power was immediate and intense. From what I've seen, a certain amount of joylessness tends to come along with any similar treatments as they cut down hunger enough to dampen the brain's reward signals. Based on my size and medical background, I looked at having a surgical procedure done on the stomach since that gives a lasting result instead of needing regular shots.

SlowSignal40archiveMay 11
↳ replying to @KeenKettle50

They've got me doing a doctorate in fibrology already. And BAM-15 is the latest thing they've made me take on.

SlowSignal40archiveMay 11
↳ replying to @PatientHarbour23

I go along with the suggestion but with a single condition. The doctor must also agree to include the cruroplasty so the common issues with heartburn and GERD won't likely develop.

PatientHarbour23archiveMay 11
↳ replying to @SlowSignal40

Before the operation my condition was really aggressive. Even now I take medication to manage it, though much weaker compared to what I relied on over many years leading up to the procedure. Since then I've lowered the dose.

SlowSignal40archiveMay 12

My initial use of this inhaler involved a single inhalation half an hour back. Roughly twenty-five minutes after that, I noticed a faint sense of clear-headedness along with a minor boost in vigor. The dose per spray is said to be one hundred micrograms. Any further developments will be noted as they occur.

KeenKettle50archiveMay 13
↳ replying to @SlowSignal40

A guy I know told me it is a safer and more tolerable version of clenbuterol. I am going to try it next month.

SlowLedger31archiveMay 25

I've also been working to move beyond this plateau. It's been tough going for two and a half weeks with the scale moving up and down by a couple pounds. Looking for other thoughts that won't put pressure on the heart or cause worry. Experienced something odd after taking niacin along with epicatechin and six milligrams of that compound. Suspect the niacin caused it. Not a rapid heartbeat exactly but more a sense of unease along with warmth upon standing that lasted about thirty six hours. Right in the middle below the ribs. Quit the niacin and cut back a milligram on the dose and the issue went away. Maintained the calorie reduction without lacking nutrients so it wasn't from food or hydration. Caffeine bothers me lately which could have played a part. Open to additional suggestions.

PatientLedger69archiveMay 25
↳ replying to @SlowSignal40

From what a quick check with some ai info showed the breathing version barely works at all unlike swallowing it which spreads through the body more and uses bigger amounts. Thinking about testing a mix for shedding fat that has caffeine along with albuterol and yohimbine during the final few weeks of my diet phase. Still at the start of looking into this stuff. Need to watch out for that nervous feeling it can bring on. Anyone here used yohimbine or taken salbutamol by mouth?

PatientTimber45archiveMay 25
↳ replying to @PatientLedger69

Stick with reta with a good diet and gym no point going faster.

QuietSignal61archiveMay 25

Those two substances stand out as the main options since they lack any human testing from what I recall and don't call for shots either. Not being peptides means they appear either as dry powder or already mixed into liquid. Discussions have also covered the other pair though growth hormone likely delivers stronger results while needing extra personal digging. They cut workout tiredness too so expecting the pounds to drop the same as just lounging on a GLP agonist would be unrealistic. One of them shows zero results. Exploring calorie deficit phases with recovery periods plus aerobic work fits the picture. Combining a plant alkaloid decongestant with caffeine plus a pain reliever or similar vessel opener offers another route and that alkaloid sits behind the pharmacy counter for breathing relief.

QuietSignal61archiveMay 25
↳ replying to @SlowSignal40

Wow, milligrams sound way excessive. I've come across info saying no more than two hundred micrograms each day at most. Planning to grab some during the next month. For ages I figured this substance counted as an anabolic steroid.

QuietSignal61archiveMay 25
↳ replying to @SharpCinder28

Overdoses tend to happen with people who lack information about what they're using, how much, and without any extra support. I have zero worry about any legal troubles. This isn't something suitable for all individuals and shouldn't be approached casually, though the compound doesn't carry the same extreme risks as that particular illegal substance. Medical professionals frequently hand out prescriptions for a similar drug without disclosing all the downsides upfront.

QuietSignal61archiveMay 25
↳ replying to @PatientTimber45

Man this acts so much like ketamine with those wild effects 😲😲😲 The stronger case against clen centers on how it wrecks cardiac function along with mineral levels and pushes blood pressure higher instead of any reference to past animal use.

PatientTimber45archiveMay 25
↳ replying to @QuietSignal61

I'd steer clear of ketamine entirely though dropping pounds with cocaine and crack works if that's your choice and it could happen quicker than those glp1 options while adding cigarettes on the side

QuietSignal61archiveMay 25
↳ replying to @PatientTimber45

What if some money reached you first, would a tin of horse flesh come back in the mail?

KeenQuill92archiveMay 25

When avoiding GLP1s I turn to small molecules instead, stuff like bupropion, naltrexone, phentermine, and the like.

BrightMarble62archiveJun 14

Uncertain whether it applies to equines, possibly. Back then it could be obtained straight from the counter at drugstores across parts of that region. Promotion occurred extensively via print publications prior to widespread online access. The substance delivered good results for me. Occasional shakiness occurred but nothing worse, though I skipped any lab tests. Dosing involved checking body heat daily and increasing intake until it stabilized. Given current alternatives I have no interest in repeating that approach especially with risks of cardiac harm.

CopperSignal27archiveJun 15

This new compound is starting to show up now and came with minimal unwanted reactions below three milligrams plus solid results dropping pounds. During my time on the other peptide I wondered if smaller weekly amounts around one milligram had been tested. That produced nine percent body mass decrease across twelve months while keeping adverse effects minimal thanks to the reduced quantity.

LevelBramble14archiveJun 15
↳ replying to @BlueBeacon34 (opening post)

If I ended up facing something like that, MOTS-C would be the option I'd pick for myself.

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