Retatrutide effects on resting heart rate blood pressure and sleep

Been using it for 5.5 weeks now, started at 1mg a week split in two doses for the first 4.5 weeks then went to 1.4mg last Tuesday, and my heart rate hasn't really moved. I lift heavy four days a week plus one long hike, same as the last ten years, and resting rate sits around 48-52 normally but has been 54-55 lately while max during activity went from 165 up to 169-170.

Sixth 1. It changes from person to person. Mine normally runs 70-72 but sits 76-80 on this. During sleep it's 53-65.

Two months in, now at 5mg. Resting rate went up 10 bpm on average from 72 to 82 and has stayed there.

Haven't felt anything different but the numbers show a change. Started tirz in December then reta in January with fast increases. Five-year Apple Watch average was 63 bpm. Unless you already have heart problems or a resting baseline over about 80, this gets talked about more than it needs to.

Started on March 24 and you can see the upward trend clearly since then, though I don't notice it in daily life.

Yeah it pushed my resting rate up around 15 bpm even at 4.5mg a week so I switched over to tirz instead.

Never noticed any rise in my rate so I guess I'm one of the lucky ones.

Yeah it pushes it too high.

Mine sits 10 higher than my old resting rate but the benefits make it worth it for me.

My rate has stayed a steady 8 bpm higher since I began.

Most don't feel obvious changes but measurements show a bigger rise on this than with the other glps. It only becomes an issue if the increase is large, say over 15, which isn't common but can happen if you already have heart disease, in which case tirz might be safer until more data comes out. If you get anxious easily and notice palpitations with that anxiety then it could matter. The rise usually eases back toward normal over months. You can always lower the dose or switch if it feels unpleasant. With diagnosed panic disorder I'd lean toward tirz since a couple people here reported panic episodes though it's not documented in studies.

Yes it did and by a fair amount. Three months in I went from 58-60 at rest to 71-73 using the Oura ring. Worried about stressing my heart so thinking about switching.

Titrated from 2mg up to 4 for a few months and now at 6 for the last few weeks with nothing noticeable for me.

No rise in resting rate at all on reta, currently at 2mg every five days and planning to move to 3mg a week since that schedule works out to 2.8mg weekly.

Came across this interesting video about the heart rate increase on reta.

My guess is most aren't using a continuous tracker like a watch or ring. Glad I have years of baseline data from mine. Wouldn't notice the bump just by feel.

Only two weeks in at 1mg and no difference for me. Walk five miles regularly and lift four times a week. Resting rate still at 62.

It made me tachycardic even while sleeping though it never felt uncomfortable. Discomfort often comes down to how much attention you pay to body signals. If you're very tuned in or anxious you might read too much into it. I treated it as data and ran an ECG plus 24-hour Holter to check nothing was damaged. Figure my heart's glucagon receptors are either more plentiful or just respond more to the cyclic AMP signalling glucagon sets off.

Back when I took just two milligrams weekly my resting pulse climbed from the usual sixty up toward seventy. These days on over four milligrams per week during cycle two it has dropped again into the low sixties. Workouts still make my heart rate climb quicker than it used to.

After mild activity on my way into the office my heart rate jumped three separate times so I quit. I'd already worn a fitness tracker for three years by then and it had never flagged anything either before or after I dropped that medication. My time on it was short just a few weeks at the starting level. I'm thinking about going back on if the pounds creep up again or maybe switching to something else like it.

Hasn't affected my heart rate in any way I've noticed the whole time I've been on it.

Mine has actually moved closer to normal when I check in the mornings lately.

No change at all according to my apple watch.

Really want to try reta since loss has slowed on tirz and I'm still 45 lbs from goal. Have borderline high BP and a beta blocker script. Wonder if the blocker would stop my rate from climbing too much on reta.

Week one of reta at 2mg but I've been on tirz for about 2.5 years so not new to glps. Apple watch hasn't shown any change yet.

8mg. Just checked mine at 72 bpm with 100% O2 level.

On reta since September last year starting at 2mg a week up to 10mg by January then down to 5mg now. Resting rate won't drop below about 78 unless I get at least 6.5 hours sleep, don't eat within two hours of bed, and finish workouts 2.5 hours before bed. If I don't stick to that the rate stays higher. Before reta it averaged around 63 at night. Thinking of dropping closer to 3mg split since loss is basically done and I'm looking at maintenance but still want the hunger control and other benefits. Not sure yet what the lowest effective dose is for me.

My average resting rate went up by around 5 bpm. Not a major issue overall. I tracked it well before starting reta so the baseline was already solid.

My resting heart rate moved from the 63-67 range up to 72-73 after beginning reta. Nothing felt off and the only sign was what my fitbit showed.

On 4 mg weekly. No change at the moment.

Over the first eight weeks my heart rate rose about 10 beats per minute, but this past week it has started dropping again. That is good to see. Starting from the low 60s and moving into the low 70s was not really a problem.

I used to sit right around 65 bpm and now I am around 72. My blood pressure started at 145/85 and after two months it is down to 130/78. The bpm rise seems like a worthwhile trade-off.

My resting heart rate climbed about 10 bpm. During workouts my heart rate now reaches max much quicker than before reta, so I need longer rests between sets or more walk breaks while running or else I start to feel off.

While I was on it for a couple months my resting heart rate rose about 6 bpm over time. Dosing went from 500 mg weekly down to 2 mg weekly.

Mornings right after waking it sits at 70-72, afternoons 76-78. While sleeping it ranges from 53-58 depending on how well I actually sleep.

Reta raised my resting heart rate by roughly 10-12 bpm on average and dropped my HRV from around 80 down into the 30s. That is one reason I am moving over to tirz instead. Long-distance running is my main activity so I am not comfortable with that big a shift in heart metrics. Happened at 5-7 mg weekly. Sleep, supplements, and hydration were all good, leaving reta as the only variable.

Eleven weeks on reta, now at 3 mg. No change in heart rate. Mid-day reading today was 106/63 with pulse at 57.