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Maintenance - How are you maintaining?

24 replies18 peopleOct 4, 2026☆ Follow
Summary

How do people transition from weight loss to maintenance dosing on drugs like retatrutide and tirzepatide?

Users report a range of approaches once at goal weight. Some keep the same weekly dose that got them there while increasing calories, others lower the dose gradually or space injections further apart. A few plan to switch compounds or add fasting. Most monitor weight trends with moving averages and adjust only when needed rather than following a fixed taper schedule.

What this discussion establishesWhere people disagree

Whether to reduce the dose right away or hold steady for months to confirm stability

Still open

How long any given maintenance regimen will remain effective or accessible

Nothing here is advice.

24 replies · 18 people
WryFenwick45archiveopening postOct 4

Feels like the end might finally be in sight, with maybe fifteen more pounds left. After that comes lifelong maintenance, and the new year could be the right moment to shift into that phase. Right now the weekly amounts are 4 mg RETA plus 0.5 to 1 mg Cagri, and those levels have never been exceeded. The open questions are how to start the maintenance stage: begin lowering the amounts, make an abrupt cut, or move from weekly to monthly shots? Roughly three months remain to sort it out. Once the target is reached, is the dose locked in permanently, tweaked over time, or stopped and restarted later?

RustLantern55archiveOct 4

Just getting into maintenance by moving from 10 mg down to 7.5 mg of tirz and stretching it to every other week. Appetite has returned, which helps because intake was too low earlier.

LevelWillow41archiveOct 4

If the dose that reached the goal is still tolerable, it may be worth holding there for a while to observe what happens next. Adjustments can be made later if weight trends start to shift slowly.

LevelThistle44archiveOct 4
↳ replying to @WryFenwick45 (opening post)

Match the dose to results while staying under the side-effect limit. The amount needed just to hold weight steady will usually be lower than the amount that produced the loss. On maintenance the relevant sides are things like daily quality of life or how much effort is still required to manage hunger and food thoughts. The practical method is to weigh regularly, track a simple moving average, and allow some buffer so small daily swings do not trigger constant changes. A fourteen-day average from daily weigh-ins cuts down the noise. After enough time a dose and schedule that simply works should appear and can be kept until something alters the equation. Current cut is 20 mg Reta plus 2.5 mg Tirz plus 1 mg Elora each week. An August trial suggests dropping Reta to 8 mg per week at the start of maintenance. Depending on how sides feel, Reta may be reduced or removed while Tirz or Elora is adjusted. Mid-November is the rough target for reaching maintenance, subject to how the last abdominal fat responds.

CopperTimber28archiveOct 4

Already in maintenance and keeping the same amounts: 7.5 mg tirz every six days, then 2 mg reta three days after that. This routine has held for a couple of months with no further loss and no urge to change yet. The aim now is to add muscle and reduce the remaining loose skin on the inner arms and thighs, which has been slow to tighten.

QuietFenwick11archiveOct 4
↳ replying to @WryFenwick45 (opening post)

Six months into maintenance on the same dose used for the final stretch of loss. One shot per week works fine and keeps the schedule simple. Scale weight has been fairly steady, and the small additional drop has been almost all fat, so body composition has improved. The current dose probably will not stay fixed forever, but any reduction will be gradual and only when it becomes necessary.

SteadySparrow75archiveOct 4

At goal weight and planning to hold 5 mg tirz on Mondays plus 5 mg reta on Thursdays. Instead of lowering the GLP doses, the plan is to raise daily food intake. More calories were already possible during the loss phase but not desired. The GLPs act as a firm floor and there is reluctance to let that protection slip and allow food noise to return.

CopperPebble16archiveOct 4

Admires the confidence that an inexpensive unofficial supply of Reta will stay reliable for maintenance across the next twenty years until a generic version appears.

WrySignal35archiveOct 4
↳ replying to @WryFenwick45 (opening post)

Close to goal and still working out the right maintenance level. The highest dose reached was 3 mg Reta; currently 2 mg once a week looks like it may be the right amount. One milligram was hoped for, but realism is needed because returning food noise would be hard to ignore.

IronLantern24archiveOct 4

Maintenance has kept the reta dose unchanged so far, with daily calories increased instead. A small reduction in reta has just begun so tirz can be added, with the longer-term goal of using more tirz than reta each week.

IronLantern24archiveOct 4
↳ replying to @CopperPebble16

Cannot picture the main overseas source ever walking away from such a large revenue stream, so some route to the consumer will probably remain open.

WryFenwick45archiveOct 4
↳ replying to @IronLantern24

Just wondering why the shift toward more tirz, no criticism intended.

LevelThistle44archiveOct 4
↳ replying to @CopperPebble16

Asking whether that means pharmacy prices will drop or grey-market access will change in some way.

IronLantern24archiveOct 4
↳ replying to @WryFenwick45

Tirz gives stronger appetite control while reta has been causing noticeable anhedonia.

AmberBeacon57archiveOct 4

Down forty pounds but still ninety short of goal, so maintenance is still months away. Past losses have always led to strong rebounds, which is the main worry. Weight loss stops if calories fall below 1200, so an alternate-day fasting pattern was adopted: maintenance calories one day, fast the next. Some form of fasting once or twice a week will probably stay necessary along with whatever GLP ends up being most effective.

AmberMeadow80archiveOct 4
↳ replying to @LevelWillow41

Same idea here. At 4 mg per week a kind of balance has appeared around 140 pounds. Appetite has returned yet extra eating has not produced weight gain. Only a couple of weeks into this approach so far and it seems to be holding. Would be interested in updates on any switch to a different schedule.

WarmAnchor49archive6d

Been holding steady for fifteen months now. Still taking Tirz at ten milligrams every seven or eight days, two milligrams of Sema on the same schedule, and two milligrams of Cagri likewise. The three together feel great so I have no interest in changing anything except maybe stretching the gap by a day. I keep thinking about stopping the Cagri but haven't been able to do it. Intake runs around fourteen to sixteen hundred calories daily, mostly keto style. Workouts have gone up quite a bit: swim a mile twice a week, walk three miles twice a week, body pump three times a week, and now adding stage two cardio into the body pump sessions. Seventy female, started at two hundred fifty, currently one thirty eight to one forty, five foot four. Dropped from size twenty to a four or six. Loving every bit of it.

Hard to follow what he is saying sometimes. I answer one of his gloomy forecasts and then he moves on to something else entirely… meh

GreyAlder96archive6d

It depends on the situation. If weight is still coming off when maintenance starts then the dose probably needs to come down while calories go up until balance is reached. If weight has already leveled off then that dose and food level are probably the right ones. I would keep the same frequency either way. I already split into two shots a week because otherwise the hunger gets rough right before the next one.

You don't need faith, just your own twenty-year supply.

NorthWillow72archive6d

All of this. Been on fifteen milligrams of Tirz since August twenty twenty five. Eating more yet the scale still edges down a little. If too much comes off I will lower the dose. Staying weekly and never stacked, down twenty seven percent.

PlainAlder11archive6d

Only reta, started at the beginning of the year. In maintenance myself for about six weeks. Dropped from ten milligrams to eight, then six, then tried four. Four felt awful so now I move between six and eight depending on the Friday scale reading. Up a pound or two then down a pound or two, basically holding steady. Eating a little more, nothing extreme, and a few extra beers now and then. The stubborn belly fat keeps shrinking slowly though, and the sit ups plus weight lifting are probably helping.

GreyHarbour55archive5d

Maintenance since May twenty twenty five. Started with one milligram reta and point one two five cagri. Titrated reta up to three milligrams with point two five cagri for maintenance. Stopped the cagri in November twenty twenty five after dropping about fifteen extra pounds past goal without meaning to. Still on three milligrams reta once a week and weight has stayed stable.

SlowSignal74archive5d

I've been following this approach myself. Reached my goal weight about a year ago. After that I changed to a different medication because of the cost and adjusted the amount based on how I felt and what the scale showed. Not long ago my weight crept up a few kilos and I wasn't satisfied with the current one but couldn't pay for the earlier option so I tried another through different channels and that got me back where I want to be. I see this as something that will need to continue long term.

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