Calculators / MK-677 dose charts
MK-677 dose charts (mg → U-100 units)
Units to draw on a standard U-100 insulin syringe, for each common MK-677 vial size and BAC-water volume. Doses shown reflect ranges reported in published research — they are reference points for the math, not recommendations. For other numbers, use the live calculator.
25 mg vial
| Dose | + 1 mL water (25 mg/mL) | + 2 mL water (12.5 mg/mL) | + 3 mL water (8.33 mg/mL) |
|---|---|---|---|
| 10 mg | 40 u | 80 u | > syringe |
| 12.5 mg | 50 u | 100 u | > syringe |
| 20 mg | 80 u | > syringe | > syringe |
| 25 mg | 100 u | > syringe | > syringe |
50 mg vial
| Dose | + 1 mL water (50 mg/mL) | + 2 mL water (25 mg/mL) | + 3 mL water (16.67 mg/mL) |
|---|---|---|---|
| 10 mg | 20 u | 40 u | 60 u |
| 12.5 mg | 25 u | 50 u | 75 u |
| 20 mg | 40 u | 80 u | > syringe |
| 25 mg | 50 u | 100 u | > syringe |
Formula: units = dose ÷ concentration × 100 · concentration = vial mg ÷ water mL · MK-677 half-life ≈ 24 h (PubMed 8954022 (Chapman 1996, J Clin Endocrinol Metab — oral MK-677 human PK/PD; t½ ≈ 24 h supports once-daily dosing))
See also: MK-677 half-life & decay curve · MK-677 reconstitution calculator
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