Half-lives / MK-677
MK-677 half-life
MK-677 stays in your system about 5 days — five half-lives at a half-life of ≈ 24 h (24 h). The computed decay curve is below, with the primary source cited.
Also searched as: mk677, mk-0677, ibutamoren, ibutamoren mesylate, nutrobal.
Source: PubMed 8954022 (Chapman 1996, J Clin Endocrinol Metab — oral MK-677 human PK/PD; t½ ≈ 24 h supports once-daily dosing)
Frequently asked
How long does MK-677 stay in your system?
With a half-life of ≈ 24 h, roughly 97% of a single MK-677 dose is cleared after five half-lives — about 5 days. Repeated dosing accumulates and takes correspondingly longer to clear.
What does a ≈ 24 h half-life mean in practice?
Every 24 h, the remaining amount halves: 100% → 50% → 25% → 12.5%, and so on. The curve above plots exactly this decay for a single dose.
Where does this MK-677 half-life number come from?
PubMed 8954022 (Chapman 1996, J Clin Endocrinol Metab — oral MK-677 human PK/PD; t½ ≈ 24 h supports once-daily dosing). We cite a primary source for every half-life we publish and version every change.
Related: MK-677 reconstitution calculator · MK-677 dose charts
Related half-lives
Other Growth-hormone & IGF axis — how long each stays active:
Guides mentioning MK-677
See your own estimated levels
The Zyra Track app plots this curve from the doses you actually log — accumulation, overlaps, and all. Free during the founding period.
Zyra Track is a research and educational utility. Nothing on this page is medical advice, a dosing recommendation, or an endorsement of any compound. We never sell or source compounds and refuse sourcing questions. Consult a qualified clinician for decisions about your health.