Retatrutide appetite loss duration, vial freshness, and treatment breaks

Yeah I double-check with the calculator too because the ocd kicks in. Was that 8 mg from the same vial or did you mix a new one? This at least makes me think it might not be just me.

Used two fresh vials mixed with 3 ml bac each, pinning 4.2 units for the 8 mg dose. We finished the previous strength and now do two vials at once up to the higher amount. My wife uses it as well.

Exactly the same for me. Everything worked extremely well for three months then it just switched off. Even going up to 12 mg weekly did nothing after that. I started a six-week break about three weeks ago to see if it resets and will update later.

It really is strange. Let me know how the break goes because I would like to hear if it actually resets things.

Good point. I tried new vials and even switched sources just in case but got the same result with little to no effect.

Understood. I am going to mix the new higher strength vial and use that to test. My wife is switching from sema to reta and I want her on a fresh one too. Very odd situation. I have a smaller kit arriving soon that I might mix right away to check if the issue is the vial or just me.

What starting amount are you planning for her and what size vial will you mix?

Mixing a 10 mg vial with 2 ml bac and starting at 0.5-1 mg. She is still on tesa from before. I do not want to go too high and overwhelm her but I have read that someone already on a glp-1 might not notice much at that low level.

We do see notable degradation sometimes before the 60-day point with reta since it is not as stable as tirz. There is a difference though between purity low enough to be unsafe and purity so low it just reduces the effect. The degradation we notice is usually the first kind unless there is a big sterility problem which should not happen in two months with decent bac water.

I am also staying under my 2400 calorie limit while hitting protein and carbs. Training hard four days a week plus cardio on rest days but the weight is stalled. A new kit arrived so I will probably try that and see.

I have read the same which is why I am wondering. This vial came from a place I used before I started ordering overseas myself. It was mixed with the standard bac water. Like I said I am going to try the new smaller vials I received to see if they feel stronger than the current 60 mg one.

I took 7 mg this week and still get full fast but also get hungry fast again. Nothing like that first 4 mg dose.

Same here. I am always hungry. The strongest suppression was at 1 mg in the first couple weeks and it has never been the same since.

I would not mind the hunger so much but being in a deficit with stalled weight makes me wonder if it just is not working anymore. At 4 mg I had more energy and no daytime crashes and now I am not getting those reta benefits. Or maybe it is all in my head.

How long do you plan to stay at the current doses? I believe in four weeks at each level. Wait until you reach 8 mg because that is when things change.

I did jump up this week faster than usual. Previously I waited about two weeks or until hunger and food noise returned which happened around two weeks at 4 mg.

A lot of you want to rush the dose increases. Let the last dose build up in your system first.

You are right. But when I reached 4 mg after titrating from 0.5 it worked immediately.

One reta container showed up as unusual in the analysis. I believe they came from one batch, though I might be incorrect.

That is pretty interesting.

I waited four weeks between each increase. Once at 4 mg I stayed there about six weeks to be sure I was comfortable. When I went to 6 mg I got some odd heart rate issues so dropped back to 4. Was not rushing at all.

I just heard a podcast where someone said they got extra hungry at a higher dose of reta and it worked better at a smaller dose.

I have been on reta almost six months and stayed at each dose for exactly four weeks before going up by 1 mg. Now on week two of 6 mg and the noise and hunger are stronger than before I started. Interesting point but going back down does not seem like the answer at this stage. I will switch to cagri soon. Was going to give reta one more try at 6 mg but at this rate I will eat everything in the house.

Completely wrong. I just did my second 8 mg and it killed my appetite. Much different than the 2-6 mg range. I am still eating because I need to but get full extremely fast.

They could be from different sources which would support staying away from cheap no-name options.

For sure. That is always sound advice.

I appreciate the information. Variations exist across sources, containers, fill levels, and product breakdown. Perhaps certain versions lose potency quicker than the rest. My previous supply performed exceptionally well. The current one comes from another provider and isn't delivering comparable effects. Despite keeping my eating habits identical with no adjustments, I put on four pounds in fourteen days. I raised the amount by one milligram. Should this fail to improve things, I'll switch to an alternate supply stored in the freezer. If that yields nothing either, I'll revert to my initial product source. Fortunately, I've reached my target body mass, making minor weight shifts irrelevant. The belt remains fastened at the smallest notch I created.

That blows my mind.

My wife just started feeling it and it hit her hard. It was funny because it was the second dose with the new vial that must have built up on her. I also have her pinning every six days. The little to no appetite and food noise are working great but I have to remind her to hit her protein. It is still working for me too. I am curious to try reta from the new batches from other sources that had good reviews and testing to see if it hits different.

No need to throw the vial away and you did not shake it too hard. Some batches just behave differently. I calculate my mix using the actual measured volume in the vial rather than the label.

Appreciate the update, I have heard similar stories and someone on this thread mentioned getting nothing at certain doses then jumping to 8 mg and feeling it again. My wife is clearly losing and her waist is getting smaller. On the shaking question, what exactly did you do when you mixed it? I just let the BAC water run down the side and then roll the vial until it clears.

Like others said here, hold off on tossing it unless you are well past the 28 to 30 day point after mixing.

Right, I will keep a vial going for ten weeks after mixing but have not gone beyond eight weeks yet. This current batch is set for seven doses at 8 mg, four already done and three left, so seven weeks total.

A two to four pound swing from morning to night is pretty normal. I see the same drop overnight. It is a known thing with weight loss and body recomp, nothing to stress over. The whoosh effect describes that sudden overnight drop after a plateau when the body releases retained water from shrinking fat cells.

This happened to me not long ago. I only dropped two pounds over three weeks then suddenly lost two pounds in three days.