CommunityTraining & Muscle

Cardio exercise and Reta

34 replies25 peopleFeb 27, 2026☆ Follow
Summary

How does retatrutide affect cardio performance, heart rate, fatigue, and strength for people who lift weights and do regular cycling or running?

Users report mixed experiences: heart rate often rises 5-15 bpm but does not always disrupt sleep or performance. Some feel no difference in cardio or lifting, while others note reduced stamina at higher intensities, occasional nausea, or lower energy tied to calorie deficit. Weight loss itself makes activities feel easier for many. A few time doses around rest days to avoid light-headedness during workouts.

What this discussion establishesWhere people disagree

Whether retatrutide reduces stamina and lifting performance more than tirzepatide, and whether the heart-rate rise is a meaningful limiter for endurance athletes.

Still open

How effects change over longer periods or at different doses, and the best way to schedule dosing around training days.

Nothing here is advice.

34 replies · 25 people
SlowLantern46archiveopening postFeb 27

Hey everyone, I'm wondering about those who lift three or four times a week as long-time lifters and also do plenty of cardio. How does cardio feel once on reta? Any loss of strength or extra fatigue? I average about 2500 miles a year on the road bike from March through December and take the winter off even though I probably shouldn't. I'm looking into this now because I want to lose 30 pounds of stubborn fat. I'm 6'5" and 255, aiming for a lean look with some definition. Thanks in advance.

QuietFenwick11archiveFeb 27

I've gained some strength. Cardio feels about the same except my heart-rate numbers run higher on retatrutide. I'm also doing less cardio overall because I'm trying to keep muscle.

WryLedger77archiveFeb 27

I don't have anything useful to add but I'm also curious to hear what others have experienced with those same questions.

PlainAlder11archiveFeb 27

No exercise for me. The heart-rate thing is interesting though, the stuff I've read about reta mentions it. My usual reading is 72-76 when I'm just sitting after walking back from the kitchen or similar. At a recent doctor visit it was 76. I got a new Sleep Number bed that tracks heart rate and it showed 64 while sleeping. I've been on reta eight weeks now.

SlowLantern46archiveFeb 27
↳ replying to @QuietFenwick11

Has the higher heart rate messed with your sleep? I read it's usually an 8-10 bpm bump.

IronThistle53archiveFeb 27

I ride about 12 miles each way to work. Honestly it doesn't feel any different, but I've dropped 20 pounds so carrying less weight makes the ride easier.

SlowLantern46archiveFeb 27

I should get a health tracker. Sometimes I don't really want to know though, which is probably not the best mindset. Good info, thanks.

LevelThistle44archiveFeb 28
↳ replying to @SlowLantern46

I don't obsess over the numbers. I have an Apple Watch and an Oura Ring. There might be more accurate options out there but these work for what I need without much hassle.

QuietFenwick11archiveFeb 28
↳ replying to @SlowLantern46

It hasn't affected my sleep. The heart-rate increase for me has been closer to 15 bpm.

PatientCompass47archiveMar 1

I do 25 minutes of fasted zone-2 cardio five days a week on the treadmill at 3 mph with a solid incline.

PlainAnchor18archiveMar 1

Cyclist and triathlete here. It depends on intensity. True zone-2 efforts don't feel that different except it's harder to stay in the lower end because of the baseline elevation. Harder sustained efforts or intervals are where it shows up more. I feel a bit limited at the top end, like my tank empties faster, though it's not dramatic. Not related to heart rate, but in hot weather I have trouble getting enough fuel and fluid in without hitting nausea because of the fullness feeling. Hope that makes sense.

PatientQuill76archiveMar 1
↳ replying to @SlowLantern46 (opening post)

I just started reta and the morning after dosing I went to the gym as usual and got light-headed with a fast heart rate on the treadmill. I've switched to taking the dose on my rest days instead.

WarmBramble98archiveMar 1

The raised heart rate is one reason I'm still deciding whether to switch from tirz to reta. I'm a runner doing 40-60 km a week focused on 5k and 10k. I notice an upper limit when pushing hard and sometimes some nausea during hard efforts the days after an injection, though that's not from the heart rate. My heart rate came down after a few months but is still 5-10 bpm higher than before. Curious how reta compares to tirz on that.

LevelAlder78archiveMar 1

I'm having a bit of a struggle in the gym. Random waves of nausea hit and the same weights feel harder. Could just be the calorie deficit and weight loss. Started reta about four and a half months ago and I'm at 3.5 mg.

WarmBramble98archiveMar 1
↳ replying to @LevelAlder78

Yeah, calorie deficit and maybe low glycogen or not enough carbs. Try eating more often if meals are tough. Don't rush the weight loss.

AmberSparrow73archiveMar 1

I've exercised my whole life. Now in my late 60s I do about 30 minutes of resistance work three times a week and walk 6-8 miles every day. During six weeks on reta I didn't notice any change in my numbers or how exercise felt. I'm now trying tirz and so far it's the same.

LevelAlder78archiveMar 1
↳ replying to @WarmBramble98

I'm going slow, only down about 19 pounds in almost five months. I try to hit at least 100 g of protein a day but probably should be closer to 140 g, and I probably don't eat enough carbs either.

PlainBeacon66archiveMar 2

I've been on reta about five weeks and lost around 12 pounds. No noticeable weakness in lifting even though I go five days a week. Strength is holding steady and no change in heart rate during my usual 30 minutes of cardio. On wegovy I did lose strength, so this is different.

WarmAlder42archiveMar 2

Reta has definitely changed my workouts. On tirz alone I could usually find the energy to hit the gym and reach my lifting targets. Since adding reta back in January I've struggled with several lifts that used to be fine. I'm trying to carb up beforehand but it doesn't seem to help much. Interesting how individual the responses are. I'll finish the reta plus tirz experiment at the end of the month and see if lifts return to normal once reta is out of my system. I know the thread is about cardio but lifting is basically my main cardio.

PatientQuill76archiveMar 2
↳ replying to @WarmAlder42

Are you running reta and tirz together? I've been thinking about trying that.

GreenHarbour58archiveMar 2

I feel like my heart rate is higher than usual. Strength is about the same but stamina feels lower. Not sure if it's just from the big calorie cut.

WarmAlder42archiveMar 2
↳ replying to @PatientQuill76

Yes, I've been stalled on tirz for months so in January I added some reta hoping the glucagon part would help break the plateau. I'm keeping tirz at a reduced 8 mg and now at 5 mg of reta. It seems to be helping with fat loss in certain spots like stomach and arms, but the sleep disruption and energy drag are real downsides. I only planned the combo for two or three months and I'm nearing the two-month mark. I'll decide then whether to continue another month or drop back to just tirz to get sleep and energy back.

PatientHarbour61archiveMar 3
↳ replying to @PlainAnchor18

The issue is that it's no longer a true zone-2 effort. Heart rate is just a proxy for metabolic demand, so when you alter heart rate the whole curve shifts. You have to recalibrate your zones to match the actual metabolic demand or you might just be working in zone 1 without realizing it.

GreyCompass16archiveMar 3

I didn't notice much difference myself. I do six-week cycles of cardarine though, and that definitely improves my cardio within three days. I stick to 10 mg a day and don't run it longer than six weeks because of the earlier studies.

PlainAnchor18archiveMar 5
↳ replying to @PatientHarbour61

I get that, but the point about true zone 2 is more about when friends suggest a zone-2 ride that actually ends up being zone 4 or 5.

SteadyPebble62archiveMar 11

Cardio has felt pretty much the same. My Apple Watch hasn't shown a higher resting heart rate. I do feel like I have a bit more stamina lately, though that might be from working on running form and getting new beginner shoes I really like.

LevelWillow41archiveMar 11
↳ replying to @LevelAlder78

My experience is pretty similar. Motivation to show up is higher than ever but performance in a calorie deficit with random nausea is worse. I manage two or three lifts and then walk uphill on the treadmill for 30-40 minutes or until nausea stops me.

LevelAlder78archiveMar 11
↳ replying to @LevelWillow41

I've found that nibbling on a couple almonds or a bite of protein bar makes the nausea pass. It's annoying because it usually hits right after a heavy set. I'm experimenting with different pre-workout nutrition to see if it helps.

SlowTimber14archiveMar 11

New to reta, fit 59-year-old male in week six. I notice the heart-rate increase but not in a bad way, more like the motor is revved a little. No noticeable change in athletic performance either way. I just feel like the reta is active, if that makes sense, like something else is onboard doing things that all seem positive right now.

LevelWillow41archiveMar 11
↳ replying to @LevelAlder78

I might pack a couple of treats into the bag I take for workouts to test whether nibbling on a little bit makes any difference.

ClearWillow59archiveMar 12
↳ replying to @PatientQuill76

Reta actually peaks the next day or later. The GLP-1 tracker app can show the timing.

AmberHarbour39archiveMar 12

I'm 46, lift three days a week and box most days. Boxing felt hard at first when I started reta, probably because calories dropped sharply. Now at six months in there's no effect on boxing. My cardio has actually improved because I'm not carrying the extra weight anymore.

CopperKettle93archiveMar 12
↳ replying to @LevelAlder78

That's going to be the tough part for me. Around 200 g protein and 60-80 g fat means fitting in carbs when I'm not hungry will be harder than it was twelve years ago.

KeenSignal35archiveMar 14

About five days before starting reta my non-fasted glucose at the doctor was 73. The first week on reta I had symptoms that felt like low blood sugar. I'd eat some quick carbs like a banana or oatmeal and feel better. It happened two or three times. Once I stopped going so low-carb the symptoms went away.

RustBramble50archiveMar 17
↳ replying to @SlowLantern46 (opening post)

Good post and useful to read people's results. I'm interested in this too. I was at the gym two or three times a week plus a couple runs. Now training for a half marathon in two weeks, after that I'll probably shift back to gym focus but keep some running because of another trail half in September. Really don't want to see running performance drop, but I was only planning a short-term quick cut to get a bit leaner anyway. Curious if that plan sounds reasonable based on what others have seen.

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