Half-lives / Mazdutide
Mazdutide half-life
Mazdutide stays in your system about 40 days — five half-lives at a half-life of ≈ 8 days (192 h). The computed decay curve is below, with the primary source cited.
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Source: Mazdutide GLORY-2 (JAMA 2026, PMID 42251595); once-weekly dosing
Frequently asked
How long does Mazdutide stay in your system?
With a half-life of ≈ 8 days, roughly 97% of a single Mazdutide dose is cleared after five half-lives — about 40 days. Repeated dosing accumulates and takes correspondingly longer to clear.
What does a ≈ 8 days half-life mean in practice?
Every 8 days, the remaining amount halves: 100% → 50% → 25% → 12.5%, and so on. The curve above plots exactly this decay for a single dose.
Where does this Mazdutide half-life number come from?
Mazdutide GLORY-2 (JAMA 2026, PMID 42251595); once-weekly dosing. We cite a primary source for every half-life we publish and version every change.
Related: Mazdutide reconstitution calculator · Mazdutide dose charts
Related half-lives
Other GLP-1 & incretin agonists — how long each stays active:
Guides mentioning Mazdutide
See your own estimated levels
The Zyra Track app plots this curve from the doses you actually log — accumulation, overlaps, and all. Free during the founding period.
Zyra Track is a research and educational utility. Nothing on this page is medical advice, a dosing recommendation, or an endorsement of any compound. We never sell or source compounds and refuse sourcing questions. Consult a qualified clinician for decisions about your health.